SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WU8_C_ADNC502_1 (HYPOTHETICAL PROTEIN PH0463)	1u4f	INWARD RECTIFIER POTASSIUM CHANNEL 2 (Mus musculus)	4 / 7	PHE A 262 ASN A 216 HIS A 221 VAL A 56	None	1.31A	1wu8A-1u4fA: undetectable 1wu8C-1u4fA: undetectable	1wu8A-1u4fA: 21.75 1wu8C-1u4fA: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2UXP_A_CLMA1211_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR)	1u4f	INWARD RECTIFIER POTASSIUM CHANNEL 2 (Mus musculus)	5 / 8	LEU A 222 LEU A 263 CYH A 311 VAL A 214 ILE A 269	None	1.06A	2uxpA-1u4fA: undetectable	2uxpA-1u4fA: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_A_CCSA14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2)	1u4f	INWARD RECTIFIER POTASSIUM CHANNEL 2 (Mus musculus)	4 / 6	ASN A 198 LEU A 321 ARG A 325 GLY A 323	None	0.80A	5o4yA-1u4fA: undetectable	5o4yA-1u4fA: 3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B5V_B_ECLB1001_1 (TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5)	1u4f	INWARD RECTIFIER POTASSIUM CHANNEL 2 (Mus musculus)	4 / 7	ALA A 290 ILE A 248 LEU A 231 ILE A 236	None	0.75A	6b5vA-1u4fA: undetectable 6b5vB-1u4fA: undetectable	6b5vA-1u4fA: 14.61 6b5vB-1u4fA: 14.61

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WU8_C_ADNC502_1","HYPOTHETICAL PROTEIN PH0463;HYPOTHETICAL PROTEIN PH0463","1u4f","INWARD RECTIFIER POTASSIUM CHANNEL 2","Mus musculus",4,"PHE A 262;ASN A 216;HIS A 221;VAL A  56","None","1.31A","1wu8A-1u4fA:undetectable;1wu8C-1u4fA:undetectable","1wu8A-1u4fA:21.75;1wu8C-1u4fA:21.75"],["2UXP_A_CLMA1211_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR TTGR","1u4f","INWARD RECTIFIER POTASSIUM CHANNEL 2","Mus musculus",5,"LEU A 222;LEU A 263;CYH A 311;VAL A 214;ILE A 269","None","1.06A","2uxpA-1u4fA:undetectable","2uxpA-1u4fA:20.15"],["5O4Y_A_CCSA14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2","1u4f","INWARD RECTIFIER POTASSIUM CHANNEL 2","Mus musculus",4,"ASN A 198;LEU A 321;ARG A 325;GLY A 323","None","0.80A","5o4yA-1u4fA:undetectable","5o4yA-1u4fA:3.38"],["6B5V_B_ECLB1001_1","TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5;TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5","1u4f","INWARD RECTIFIER POTASSIUM CHANNEL 2","Mus musculus",4,"ALA A 290;ILE A 248;LEU A 231;ILE A 236","None","0.75A","6b5vA-1u4fA:undetectable;6b5vB-1u4fA:undetectable","6b5vA-1u4fA:14.61;6b5vB-1u4fA:14.61"]]