SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1u4q SPECTRIN ALPHA
CHAIN, BRAIN
(Gallus
gallus) 		3 / 3 LEU A1695
VAL A1698
LEU A1702
 None
 0.47A 1mz9B-1u4qA:
undetectable		 1mz9B-1u4qA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1u4q SPECTRIN ALPHA
CHAIN, BRAIN
(Gallus
gallus) 		4 / 6 LEU A1679
GLN A1739
ILE A1672
PHE A1675
 None
 0.87A 2jn3A-1u4qA:
undetectable		 2jn3A-1u4qA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1u4q SPECTRIN ALPHA
CHAIN, BRAIN
(Gallus
gallus) 		3 / 3 TYR A1877
GLU A1888
ASP A1965
 None
 0.59A 3bxoA-1u4qA:
undetectable		 3bxoA-1u4qA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1u4q SPECTRIN ALPHA
CHAIN, BRAIN
(Gallus
gallus) 		3 / 3 TYR A1877
GLU A1888
ASP A1965
 None
 0.60A 3bxoB-1u4qA:
undetectable		 3bxoB-1u4qA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1u4q SPECTRIN ALPHA
CHAIN, BRAIN
(Gallus
gallus) 		4 / 6 LYS A1704
GLN A1706
LEU A1708
GLU A1709
 None
 0.89A 3h5gA-1u4qA:
undetectable
3h5gC-1u4qA:
undetectable		 3h5gA-1u4qA:
8.60
3h5gC-1u4qA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1u4q SPECTRIN ALPHA
CHAIN, BRAIN
(Gallus
gallus) 		3 / 3 THR A1953
VAL A1949
GLU A1939
 None
 0.66A 3v4tA-1u4qA:
undetectable
3v4tD-1u4qA:
undetectable		 3v4tA-1u4qA:
24.94
3v4tD-1u4qA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1u4q SPECTRIN ALPHA
CHAIN, BRAIN
(Gallus
gallus) 		3 / 3 HIS A1948
SER A1874
ARG A1870
 None
 0.98A 5u63A-1u4qA:
undetectable		 5u63A-1u4qA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1u4q SPECTRIN ALPHA
CHAIN, BRAIN
(Gallus
gallus) 		3 / 3 LEU A1850
ASN A1839
LEU A1771
 None
 0.65A 6exiA-1u4qA:
undetectable		 6exiA-1u4qA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1u4q SPECTRIN ALPHA
CHAIN, BRAIN
(Gallus
gallus) 		4 / 6 ILE A1672
ALA A1726
MET A1730
ASP A1736
 None
 1.07A 6hu9m-1u4qA:
1.0
6hu9q-1u4qA:
2.0		 6hu9m-1u4qA:
18.99
6hu9q-1u4qA:
19.00