SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
ASN A 466
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-4.2A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.46A 1fmoE-1u59A:
23.9		 1fmoE-1u59A:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.58A 1iepA-1u59A:
30.8		 1iepA-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 419
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
 0.86A 1iepB-1u59A:
30.4		 1iepB-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
 0.46A 1iepB-1u59A:
30.4		 1iepB-1u59A:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.7A)
STU  A 100 (-4.5A)
 0.60A 1muoA-1u59A:
7.6		 1muoA-1u59A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 ARG A 594
GLY A 448
GLU A 590
ASN A 395
ILE A 477
 None
 1.35A 1odiA-1u59A:
undetectable		 1odiA-1u59A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 ARG A 594
GLY A 448
GLU A 590
ASN A 395
ILE A 477
 None
 1.36A 1odiB-1u59A:
undetectable		 1odiB-1u59A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 ARG A 594
GLY A 448
GLU A 590
ASN A 395
ILE A 477
 None
 1.44A 1odiC-1u59A:
undetectable		 1odiC-1u59A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 ARG A 594
GLY A 448
GLU A 590
ASN A 395
ILE A 477
 None
 1.36A 1odiD-1u59A:
undetectable		 1odiD-1u59A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 ARG A 594
GLY A 448
GLU A 590
ASN A 395
ILE A 477
 None
 1.36A 1odiE-1u59A:
undetectable		 1odiE-1u59A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 ARG A 594
GLY A 448
GLU A 590
ASN A 395
ILE A 477
 None
 1.35A 1odiF-1u59A:
undetectable		 1odiF-1u59A:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.60A 1opjA-1u59A:
29.8		 1opjA-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
 0.53A 1opjB-1u59A:
29.9		 1opjB-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.54A 1t46A-1u59A:
31.4		 1t46A-1u59A:
35.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 VAL A 352
ALA A 367
GLU A 386
LEU A 452
HIS A 459
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
 0.52A 1uwjA-1u59A:
7.2		 1uwjA-1u59A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 ARG A 594
GLY A 448
GLU A 590
ILE A 477
HIS A 611
 None
 1.46A 1vhwA-1u59A:
undetectable
1vhwD-1u59A:
undetectable		 1vhwA-1u59A:
23.18
1vhwD-1u59A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 ARG A 594
GLY A 448
GLU A 590
ILE A 477
HIS A 611
 None
 1.43A 1vhwC-1u59A:
undetectable
1vhwE-1u59A:
undetectable		 1vhwC-1u59A:
23.18
1vhwE-1u59A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 HIS A 611
ARG A 594
GLY A 448
GLU A 590
ILE A 477
 None
 1.44A 1vhwA-1u59A:
undetectable
1vhwD-1u59A:
undetectable		 1vhwA-1u59A:
23.18
1vhwD-1u59A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 HIS A 611
ARG A 594
GLY A 448
GLU A 590
ILE A 477
 None
 1.46A 1vhwC-1u59A:
undetectable
1vhwE-1u59A:
undetectable		 1vhwC-1u59A:
23.18
1vhwE-1u59A:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 ALA A 367
MET A 414
MET A 416
ALA A 417
GLY A 419
LEU A 468
 STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.8A)
STU  A 100 (-3.7A)
None
STU  A 100 (-4.5A)
 1.19A 1xbbA-1u59A:
40.0		 1xbbA-1u59A:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 9 LEU A 344
VAL A 352
ALA A 367
MET A 414
MET A 416
ALA A 417
GLY A 420
PRO A 421
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.8A)
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
STU  A 100 ( 4.6A)
STU  A 100 (-4.5A)
 0.60A 1xbbA-1u59A:
40.0		 1xbbA-1u59A:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 11 GLY A 345
VAL A 352
ALA A 367
MET A 414
ALA A 417
LEU A 468
 STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.7A)
STU  A 100 (-4.5A)
 0.63A 2evaA-1u59A:
26.6		 2evaA-1u59A:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ASP A 461
ASN A 466
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-4.2A)
STU  A 100 (-3.5A)
 0.64A 2fumA-1u59A:
26.8		 2fumA-1u59A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
MET A 414
ASN A 466
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.2A)
STU  A 100 (-3.5A)
 0.59A 2fumB-1u59A:
26.9		 2fumB-1u59A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
MET A 414
ASN A 466
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.2A)
 0.63A 2fumC-1u59A:
24.9		 2fumC-1u59A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
MET A 414
ASN A 466
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.2A)
 0.49A 2fumD-1u59A:
25.3		 2fumD-1u59A:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-4.5A)
 0.60A 2gqgB-1u59A:
34.7		 2gqgB-1u59A:
38.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.52A 2gqgB-1u59A:
34.7		 2gqgB-1u59A:
38.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.45A 2hyyA-1u59A:
30.7		 2hyyA-1u59A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.48A 2hyyB-1u59A:
31.1		 2hyyB-1u59A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.45A 2hyyC-1u59A:
31.0		 2hyyC-1u59A:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		3 / 3 GLN A 444
LYS A 476
VAL A 467
 None
 0.74A 2jfaB-1u59A:
undetectable		 2jfaB-1u59A:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.51A 2oiqA-1u59A:
30.7		 2oiqA-1u59A:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 6 LEU A 337
MET A 383
MET A 384
LEU A 371
 None
 1.47A 2oz7A-1u59A:
undetectable		 2oz7A-1u59A:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 LEU A 344
VAL A 352
ALA A 367
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.84A 2xp2A-1u59A:
32.0		 2xp2A-1u59A:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 8 LEU A 344
ALA A 367
MET A 414
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.88A 2yfxA-1u59A:
31.5		 2yfxA-1u59A:
33.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		3 / 3 ASP A 461
THR A 380
GLU A 386
 None
 0.75A 2zifB-1u59A:
undetectable		 2zifB-1u59A:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
LEU A 412
GLY A 420
LEU A 468
ASP A 479
PHE A 480
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
None
 1.06A 3bbtD-1u59A:
29.7		 3bbtD-1u59A:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
GLY A 345
ALA A 367
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.48A 3c7qA-1u59A:
30.1		 3c7qA-1u59A:
33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 ALA A 367
GLU A 386
MET A 390
GLY A 420
HIS A 459
LEU A 468
 STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
None
STU  A 100 (-4.5A)
 0.64A 3cs9A-1u59A:
30.7		 3cs9A-1u59A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 LEU A 344
VAL A 352
LYS A 369
VAL A 399
PHE A 457
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-4.5A)
 0.74A 3cs9B-1u59A:
30.7		 3cs9B-1u59A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 6 LEU A 344
VAL A 352
LYS A 369
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
 0.84A 3cs9D-1u59A:
29.8		 3cs9D-1u59A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
MET A 414
ASN A 466
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.2A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.60A 3eygA-1u59A:
32.3		 3eygA-1u59A:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
MET A 414
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
 0.51A 3fupB-1u59A:
33.4		 3fupB-1u59A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 11 LEU A 344
VAL A 352
ALA A 367
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.37A 3g0eA-1u59A:
28.6		 3g0eA-1u59A:
31.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.61A 3g5dA-1u59A:
31.9		 3g5dA-1u59A:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.83A 3g5dB-1u59A:
31.7		 3g5dB-1u59A:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.57A 3gvuA-1u59A:
30.3		 3gvuA-1u59A:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 ALA A 367
GLU A 386
MET A 390
HIS A 459
LEU A 468
 STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.59A 3ik3A-1u59A:
31.5		 3ik3A-1u59A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 ALA A 367
GLU A 386
MET A 390
HIS A 459
LEU A 468
 STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.58A 3ik3B-1u59A:
31.3		 3ik3B-1u59A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
SER A 478
 STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
 0.70A 3k54A-1u59A:
24.8		 3k54A-1u59A:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.46A 3k5vA-1u59A:
29.9		 3k5vA-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.48A 3k5vB-1u59A:
29.5		 3k5vB-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
MET A 414
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.90A 3lxkA-1u59A:
32.8		 3lxkA-1u59A:
36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-4.5A)
 0.57A 3ms9A-1u59A:
30.2		 3ms9A-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.54A 3ms9B-1u59A:
30.2		 3ms9B-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-4.5A)
 0.57A 3mssA-1u59A:
30.4		 3mssA-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
 0.49A 3mssB-1u59A:
30.3		 3mssB-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.48A 3mssB-1u59A:
30.3		 3mssB-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-4.5A)
 0.58A 3mssC-1u59A:
30.3		 3mssC-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.57A 3mssD-1u59A:
30.3		 3mssD-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.67A 3octA-1u59A:
29.9		 3octA-1u59A:
37.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.60A 3oezA-1u59A:
30.4		 3oezA-1u59A:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
HIS A 459
 STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
None
 0.71A 3oxzA-1u59A:
31.5		 3oxzA-1u59A:
38.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.53A 3pyyA-1u59A:
30.8		 3pyyA-1u59A:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.60A 3pyyB-1u59A:
30.9		 3pyyB-1u59A:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.81A 3qlgA-1u59A:
31.0		 3qlgA-1u59A:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-4.5A)
 0.76A 3qlgA-1u59A:
31.0		 3qlgA-1u59A:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.75A 3qlgB-1u59A:
31.9		 3qlgB-1u59A:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.48A 3sxrA-1u59A:
32.1		 3sxrA-1u59A:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.46A 3sxrB-1u59A:
31.8		 3sxrB-1u59A:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 10 ARG A 594
GLY A 448
GLU A 590
ASN A 395
ILE A 477
 None
 1.36A 3uayA-1u59A:
undetectable		 3uayA-1u59A:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.72A 3ue4B-1u59A:
35.0		 3ue4B-1u59A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.61A 3ue4B-1u59A:
35.0		 3ue4B-1u59A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
 0.54A 3wzdA-1u59A:
30.4		 3wzdA-1u59A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 5 LYS A 369
ILE A 389
LEU A 468
ASP A 479
 STU  A 100 ( 4.7A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 1.13A 3wzdA-1u59A:
30.4		 3wzdA-1u59A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 5 LYS A 369
VAL A 399
LEU A 468
ASP A 479
 STU  A 100 ( 4.7A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.97A 3wzdA-1u59A:
30.4		 3wzdA-1u59A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
GLY A 420
LEU A 452
HIS A 459
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
None
None
 0.57A 3wzeA-1u59A:
31.1		 3wzeA-1u59A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 9 LEU A 344
ILE A 389
LEU A 393
ILE A 398
ILE A 477
 STU  A 100 (-3.8A)
None
None
None
None
 0.81A 3zosB-1u59A:
29.0		 3zosB-1u59A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 9 LEU A 344
ILE A 389
MET A 390
ILE A 398
ILE A 477
 STU  A 100 (-3.8A)
None
None
None
None
 0.75A 3zosB-1u59A:
29.0		 3zosB-1u59A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.45A 4ag8A-1u59A:
31.6		 4ag8A-1u59A:
32.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.49A 4agcA-1u59A:
31.0		 4agcA-1u59A:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 11 LEU A 344
ALA A 367
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.41A 4agdA-1u59A:
30.5		 4agdA-1u59A:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 LEU A 344
VAL A 352
ALA A 367
MET A 414
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.71A 4ansA-1u59A:
31.8		 4ansA-1u59A:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
GLY A 420
LEU A 452
HIS A 459
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
None
None
 0.58A 4asdA-1u59A:
31.1		 4asdA-1u59A:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
ILE A 389
MET A 390
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.90A 4bkjA-1u59A:
28.7		 4bkjA-1u59A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
ILE A 389
MET A 390
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.70A 4bkjB-1u59A:
28.8		 4bkjB-1u59A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 11 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.58A 4ckiA-1u59A:
34.0		 4ckiA-1u59A:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 10 LEU A 344
GLY A 345
GLY A 347
VAL A 352
ALA A 367
ALA A 417
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
None
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.7A)
STU  A 100 (-4.5A)
 0.57A 4ckjA-1u59A:
34.6		 4ckjA-1u59A:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
GLU A 386
ILE A 389
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
None
STU  A 100 (-4.5A)
 0.58A 4csvA-1u59A:
31.1		 4csvA-1u59A:
41.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		9 / 12 LEU A 344
GLY A 345
VAL A 352
ALA A 367
LEU A 412
MET A 414
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.88A 4i22A-1u59A:
29.2		 4i22A-1u59A:
33.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 ALA A 367
VAL A 399
MET A 414
GLY A 418
LEU A 468
SER A 478
 STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
 1.28A 4ks8A-1u59A:
26.3		 4ks8A-1u59A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 ALA A 367
VAL A 399
MET A 414
GLY A 419
LEU A 468
SER A 478
 STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
 1.04A 4ks8A-1u59A:
26.3		 4ks8A-1u59A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 ALA A 367
VAL A 399
MET A 414
GLY A 420
LEU A 468
SER A 478
 STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
 0.67A 4ks8A-1u59A:
26.3		 4ks8A-1u59A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 VAL A 352
ALA A 367
MET A 414
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
 0.58A 4l9iA-1u59A:
9.5		 4l9iA-1u59A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 8 GLY A 347
VAL A 352
ALA A 367
LYS A 369
MET A 414
 None
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
STU  A 100 (-3.6A)
 0.56A 4l9iB-1u59A:
24.1		 4l9iB-1u59A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		3 / 3 HIS A 473
VAL A 467
LEU A 469
 None
 0.77A 4m2vA-1u59A:
undetectable		 4m2vA-1u59A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 6 LEU A 344
GLY A 345
VAL A 352
ALA A 367
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-4.5A)
 0.29A 4o0wA-1u59A:
25.5		 4o0wA-1u59A:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 8 VAL A 352
ALA A 367
ASN A 466
LEU A 468
ASP A 479
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-4.2A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.36A 4ogrA-1u59A:
25.7		 4ogrA-1u59A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 7 GLY A 345
ALA A 367
ASN A 466
LEU A 468
ASP A 479
 STU  A 100 (-3.3A)
STU  A 100 (-3.2A)
STU  A 100 (-4.2A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.71A 4ogrE-1u59A:
25.2		 4ogrE-1u59A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 345
GLY A 347
GLY A 350
VAL A 352
ALA A 367
LYS A 369
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
None
None
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
 0.58A 4otiA-1u59A:
20.1		 4otiA-1u59A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
GLY A 345
GLY A 350
VAL A 352
ALA A 367
LYS A 369
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
None
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
 0.55A 4otiA-1u59A:
20.1		 4otiA-1u59A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 GLY A 345
VAL A 352
ALA A 367
MET A 414
GLY A 418
LEU A 468
 STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
 0.52A 4qmzA-1u59A:
28.5		 4qmzA-1u59A:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 8 LEU A 344
VAL A 352
LYS A 369
ALA A 417
HIS A 459
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
STU  A 100 (-3.7A)
None
STU  A 100 (-4.5A)
 0.59A 4qrcA-1u59A:
30.6		 4qrcA-1u59A:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 ALA A 367
GLU A 386
MET A 390
ALA A 417
HIS A 459
LEU A 468
 STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.7A)
None
STU  A 100 (-4.5A)
 0.65A 4tyjA-1u59A:
30.9		 4tyjA-1u59A:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 6 LEU A 344
VAL A 352
LYS A 369
ILE A 398
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
 0.54A 4tyjA-1u59A:
30.9		 4tyjA-1u59A:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 6 LEU A 344
VAL A 352
LYS A 369
ILE A 398
ILE A 477
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
None
 0.51A 4tyjA-1u59A:
30.9		 4tyjA-1u59A:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 10 LEU A 344
VAL A 352
GLU A 386
LEU A 393
ILE A 398
VAL A 399
ILE A 477
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
None
None
None
None
None
 0.65A 4u0iA-1u59A:
31.1		 4u0iA-1u59A:
35.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 LEU A 344
ALA A 367
GLU A 386
LEU A 452
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-4.5A)
 0.59A 4uxqA-1u59A:
30.7		 4uxqA-1u59A:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 VAL A 352
LYS A 369
ALA A 417
ILE A 398
 STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
STU  A 100 (-3.7A)
None
 0.77A 4uxqA-1u59A:
30.7		 4uxqA-1u59A:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 7 VAL A 352
LYS A 369
MET A 390
ALA A 417
ILE A 477
 STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.7A)
None
 0.83A 4uxqA-1u59A:
30.7		 4uxqA-1u59A:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 ALA A 367
GLU A 386
MET A 390
ALA A 417
LEU A 452
HIS A 459
 STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.7A)
None
None
 0.72A 4v01A-1u59A:
30.3		 4v01A-1u59A:
35.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 9 LEU A 344
VAL A 352
LYS A 369
LEU A 468
ILE A 477
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
None
 0.47A 4v01A-1u59A:
30.3		 4v01A-1u59A:
35.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 ALA A 367
GLU A 386
MET A 390
ALA A 417
LEU A 452
HIS A 459
 STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.7A)
None
None
 0.65A 4v01B-1u59A:
30.7		 4v01B-1u59A:
35.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
GLU A 386
ALA A 417
LEU A 452
HIS A 459
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.7A)
None
None
 0.73A 4v04A-1u59A:
30.2		 4v04A-1u59A:
35.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 LEU A 344
VAL A 352
LYS A 369
MET A 390
LEU A 468
ILE A 477
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-4.5A)
None
 0.59A 4v04B-1u59A:
31.0		 4v04B-1u59A:
35.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 12 ALA A 367
GLU A 386
ALA A 417
LEU A 452
HIS A 459
 STU  A 100 (-3.2A)
None
STU  A 100 (-3.7A)
None
None
 0.68A 4v04B-1u59A:
31.0		 4v04B-1u59A:
35.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 8 ALA A 367
MET A 414
LEU A 468
SER A 478
 STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
 0.46A 4wboB-1u59A:
24.0		 4wboB-1u59A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 8 LEU A 344
ALA A 367
MET A 414
SER A 478
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.1A)
 0.55A 4wboB-1u59A:
24.0		 4wboB-1u59A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 6 LEU A 344
ALA A 367
MET A 414
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
 0.57A 4wboC-1u59A:
24.3		 4wboC-1u59A:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
ALA A 367
GLU A 386
MET A 390
LEU A 412
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.81A 4wkqA-1u59A:
33.9		 4wkqA-1u59A:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.66A 4xeyA-1u59A:
35.5		 4xeyA-1u59A:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 8 LEU A 344
GLY A 345
VAL A 352
ALA A 367
GLY A 418
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
 1.17A 4zauA-1u59A:
33.7		 4zauA-1u59A:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 8 LEU A 344
GLY A 345
VAL A 352
ALA A 367
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.5A)
 0.67A 4zauA-1u59A:
33.7		 4zauA-1u59A:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 9 LEU A 344
VAL A 352
ALA A 367
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.78A 5aaaA-1u59A:
32.3		 5aaaA-1u59A:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 10 ALA A 367
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.2A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.35A 5ajqB-1u59A:
23.6		 5ajqB-1u59A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 6 VAL A 467
ALA A 475
GLN A 444
VAL A 445
 None
 0.89A 5i8fA-1u59A:
undetectable		 5i8fA-1u59A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 GLY A 345
GLY A 347
GLY A 350
VAL A 352
 STU  A 100 (-3.3A)
None
None
STU  A 100 (-4.8A)
 0.27A 5izjB-1u59A:
24.0		 5izjB-1u59A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 GLY A 345
GLY A 347
VAL A 352
ASP A 479
 STU  A 100 (-3.3A)
None
STU  A 100 (-4.8A)
STU  A 100 (-3.5A)
 0.38A 5j5xA-1u59A:
24.2		 5j5xA-1u59A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 GLY A 345
GLY A 347
VAL A 352
LYS A 369
 STU  A 100 (-3.3A)
None
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
 0.39A 5j5xA-1u59A:
24.2		 5j5xA-1u59A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 11 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
ALA A 417
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.7A)
STU  A 100 (-4.5A)
 0.39A 5lvnA-1u59A:
26.5		 5lvnA-1u59A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 10 LEU A 344
VAL A 352
LYS A 369
GLU A 386
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.5A)
 0.46A 5mo4A-1u59A:
25.4		 5mo4A-1u59A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 10 LEU A 344
VAL A 352
ALA A 367
VAL A 399
MET A 414
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
 0.66A 5n3hA-1u59A:
24.3		 5n3hA-1u59A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 8 ALA A 367
GLU A 386
LEU A 468
ASP A 479
 STU  A 100 (-3.2A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.37A 5owrA-1u59A:
21.9		 5owrA-1u59A:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 GLY A 345
VAL A 352
ALA A 367
GLY A 420
LEU A 468
SER A 478
PHE A 480
 STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.1A)
None
 1.48A 5p9iA-1u59A:
30.7		 5p9iA-1u59A:
35.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 4 HIS A 473
HIS A 608
TYR A 597
GLU A 440
 None
 1.30A 5pahA-1u59A:
undetectable		 5pahA-1u59A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.35A 5te0A-1u59A:
25.2		 5te0A-1u59A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 4 VAL A 352
LYS A 369
VAL A 399
ASN A 466
 STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-4.2A)
 0.61A 5vc3A-1u59A:
24.5		 5vc3A-1u59A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 LEU A 344
ALA A 367
GLU A 386
VAL A 399
LEU A 412
GLY A 418
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 ( 4.7A)
 0.87A 5vcvA-1u59A:
24.7		 5vcvA-1u59A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
ALA A 367
LYS A 369
GLU A 386
VAL A 399
LEU A 412
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-3.5A)
 0.98A 5vcvA-1u59A:
24.7		 5vcvA-1u59A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
LEU A 412
GLY A 418
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 ( 4.7A)
 0.79A 5vcyA-1u59A:
24.7		 5vcyA-1u59A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		6 / 12 VAL A 352
ALA A 367
LYS A 369
GLU A 386
LEU A 412
GLY A 420
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.5A)
 0.78A 5vcyA-1u59A:
24.7		 5vcyA-1u59A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 9 LEU A 344
ALA A 367
VAL A 399
MET A 414
GLY A 418
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 ( 4.7A)
 1.25A 5w5vA-1u59A:
3.8		 5w5vA-1u59A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		5 / 9 LEU A 344
ALA A 367
VAL A 399
MET A 414
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-3.5A)
 0.48A 5w5vA-1u59A:
3.8		 5w5vA-1u59A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.61A 5y7zA-1u59A:
23.9		 5y7zA-1u59A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.61A 5y7zA-1u59A:
23.9		 5y7zA-1u59A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
ALA A 367
LYS A 369
GLU A 386
LEU A 412
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.59A 5y7zB-1u59A:
24.0		 5y7zB-1u59A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.52A 5y80A-1u59A:
23.7		 5y80A-1u59A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
ALA A 417
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
 0.47A 5zv2A-1u59A:
30.1		 5zv2A-1u59A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
ALA A 417
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
 0.68A 5zv2B-1u59A:
30.3		 5zv2B-1u59A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.69A 6bsdA-1u59A:
28.5		 6bsdA-1u59A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		4 / 7 PHE A 586
ALA A 464
VAL A 438
LEU A 442
 None
 0.73A 6dwnB-1u59A:
undetectable		 6dwnB-1u59A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-4.5A)
 0.60A 6hd4A-1u59A:
29.8		 6hd4A-1u59A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-4.5A)
 0.56A 6hd4B-1u59A:
29.5		 6hd4B-1u59A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		7 / 12 VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-4.5A)
 0.57A 6hd6A-1u59A:
29.8		 6hd6A-1u59A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens) 		8 / 12 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-4.5A)
 0.64A 6hd6B-1u59A:
29.7		 6hd6B-1u59A:
15.23