SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		3 / 3 ARG A 175
TYR A 166
LYS A 164
 None
 0.67A 1uujB-1u5lA:
undetectable		 1uujB-1u5lA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		4 / 8 GLY A 123
ILE A 210
MET A 213
CYH A 214
 None
 0.77A 3ko0B-1u5lA:
undetectable
3ko0J-1u5lA:
0.4		 3ko0B-1u5lA:
18.75
3ko0J-1u5lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		4 / 8 GLY A 124
ILE A 210
MET A 213
CYH A 214
 None
 0.85A 3ko0B-1u5lA:
undetectable
3ko0J-1u5lA:
0.4		 3ko0B-1u5lA:
18.75
3ko0J-1u5lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		4 / 8 GLY A 123
ILE A 210
MET A 213
CYH A 214
 None
 0.79A 3ko0K-1u5lA:
undetectable
3ko0S-1u5lA:
0.4		 3ko0K-1u5lA:
18.75
3ko0S-1u5lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		4 / 8 GLY A 124
ILE A 210
MET A 213
CYH A 214
 None
 0.93A 3ko0K-1u5lA:
undetectable
3ko0S-1u5lA:
0.4		 3ko0K-1u5lA:
18.75
3ko0S-1u5lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		3 / 3 ARG A 156
ARG A 138
TRP A 150
 None
 1.43A 4b7nA-1u5lA:
undetectable		 4b7nA-1u5lA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		3 / 3 ARG A 156
ARG A 138
TRP A 150
 None
 1.45A 4cpzE-1u5lA:
undetectable		 4cpzE-1u5lA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		3 / 3 ARG A 156
ARG A 138
TRP A 150
 None
 1.37A 4cpzG-1u5lA:
undetectable		 4cpzG-1u5lA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		5 / 11 PHE A 176
ASP A 179
ILE A 183
ASN A 182
TYR A 163
 None
 1.40A 4rtrA-1u5lA:
undetectable		 4rtrA-1u5lA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1u5l PRION PROTEIN
(Trachemys
scripta) 		4 / 5 GLY A 136
ASN A 159
ARG A 138
ARG A 156
 None
 1.36A 6dwdB-1u5lA:
undetectable
6dwdD-1u5lA:
undetectable		 6dwdB-1u5lA:
12.80
6dwdD-1u5lA:
12.80