SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ALA A  55
GLU A  76
LEU A  80
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.73A 1uwhA-1u5qA:
24.9		 1uwhA-1u5qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 ALA A  55
LYS A  57
GLU A  76
LEU A  80
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.72A 1uwhB-1u5qA:
24.7		 1uwhB-1u5qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 VAL A  42
ALA A  55
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.75A 1uwjA-1u5qA:
7.1		 1uwjA-1u5qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 ILE A  34
VAL A  42
ALA A  55
GLU A  76
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.86A 1uwjB-1u5qA:
7.2		 1uwjB-1u5qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 9 VAL A  42
ALA A  55
MET A 105
GLY A 110
LEU A 158
 None
 0.53A 1xbbA-1u5qA:
27.6		 1xbbA-1u5qA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
VAL A  42
LYS A  57
ASN A 156
LEU A 158
ASP A 169
 None
 0.63A 2eufB-1u5qA:
27.1		 2eufB-1u5qA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 11 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
SER A 111
LEU A 158
 None
 0.46A 2evaA-1u5qA:
25.8		 2evaA-1u5qA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 GLY A  35
VAL A  42
ALA A  55
ASP A 151
LYS A 153
ASN A 156
ASP A 169
 None
 0.71A 2fumA-1u5qA:
27.4		 2fumA-1u5qA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
LYS A 153
ASN A 156
ASP A 169
 None
 0.74A 2fumB-1u5qA:
27.5		 2fumB-1u5qA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
ASN A 156
 None
 0.48A 2fumC-1u5qA:
26.4		 2fumC-1u5qA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 GLY A  35
VAL A  42
ALA A  55
MET A 105
LYS A 153
ASN A 156
 None
 0.55A 2fumD-1u5qA:
26.5		 2fumD-1u5qA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
ASP A 169
 None
 0.83A 2ivuA-1u5qA:
27.3		 2ivuA-1u5qA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
TYR A 107
 None
 0.60A 2ivuA-1u5qA:
27.3		 2ivuA-1u5qA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 4 LEU A 167
THR A  88
ILE A 148
HIS A 143
 None
 1.34A 2jfaB-1u5qA:
undetectable		 2jfaB-1u5qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
TYR A 107
GLY A 110
LEU A 158
 None
 0.68A 2oiqA-1u5qA:
24.2		 2oiqA-1u5qA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 5 LEU A 211
ILE A 157
GLY A 138
HIS A 143
 None
 0.97A 2otfA-1u5qA:
undetectable		 2otfA-1u5qA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 9 VAL A  42
ALA A  55
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 None
 0.72A 2xp2A-1u5qA:
8.0		 2xp2A-1u5qA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ILE A  34
ALA A  55
LYS A  57
GLU A  76
TYR A 107
GLY A 110
LEU A 158
 None
 0.78A 2y6oA-1u5qA:
24.8		 2y6oA-1u5qA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
VAL A  42
ALA A  55
ILE A  89
GLY A 110
LEU A 158
 None
 0.43A 2y7jA-1u5qA:
29.5		 2y7jA-1u5qA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
VAL A  42
ALA A  55
ILE A  89
LEU A 158
ASP A 169
 None
 0.70A 2y7jA-1u5qA:
29.5		 2y7jA-1u5qA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 10 ILE A  34
VAL A  42
ALA A  55
ILE A  89
GLY A 110
LEU A 158
 None
 0.54A 2y7jB-1u5qA:
30.0		 2y7jB-1u5qA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 10 ILE A  34
VAL A  42
ALA A  55
ILE A  89
LEU A 158
ASP A 169
 None
 0.80A 2y7jB-1u5qA:
30.0		 2y7jB-1u5qA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 10 ILE A  34
VAL A  42
ALA A  55
ILE A  89
GLY A 110
LEU A 158
 None
 0.51A 2y7jC-1u5qA:
29.6		 2y7jC-1u5qA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 10 ILE A  34
VAL A  42
ALA A  55
ILE A  89
GLY A 110
LEU A 158
 None
 0.58A 2y7jD-1u5qA:
29.6		 2y7jD-1u5qA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 8 ALA A  55
MET A 105
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 None
 0.55A 2yfxA-1u5qA:
25.0		 2yfxA-1u5qA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
MET A 105
SER A 111
ASN A 156
LEU A 158
 None
 0.69A 3eygA-1u5qA:
25.9		 3eygA-1u5qA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
MET A 105
TYR A 107
SER A 111
LEU A 158
 None
 0.70A 3fupA-1u5qA:
25.5		 3fupA-1u5qA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 GLY A  35
GLY A  37
VAL A  42
ALA A  55
LYS A  57
MET A 105
TYR A 107
LEU A 158
 None
 0.46A 3fupB-1u5qA:
25.3		 3fupB-1u5qA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 11 VAL A  42
ALA A  55
TYR A 107
CYH A 108
GLY A 110
LEU A 158
 None
 0.49A 3g0eA-1u5qA:
22.4		 3g0eA-1u5qA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 11 VAL A  42
ALA A  55
TYR A 107
CYH A 108
GLY A 110
LEU A 158
 None
 0.55A 3g0fA-1u5qA:
23.0		 3g0fA-1u5qA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 10 VAL A  42
ALA A  55
TYR A 107
CYH A 108
GLY A 110
LEU A 158
 None
 0.48A 3g0fB-1u5qA:
23.8		 3g0fB-1u5qA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ALA A  55
GLU A  76
LEU A  80
ILE A  89
HIS A 149
ASP A 169
 None
 1.08A 3gp0A-1u5qA:
23.0		 3gp0A-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
GLU A  76
LEU A  80
ILE A  89
HIS A 149
 None
 0.47A 3gp0A-1u5qA:
23.0		 3gp0A-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
MET A 105
TYR A 107
LEU A 158
 None
 0.76A 3lxkA-1u5qA:
25.4		 3lxkA-1u5qA:
26.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
ILE A  89
TYR A 107
SER A 111
LEU A 158
 None
 0.48A 3lxnA-1u5qA:
26.0		 3lxnA-1u5qA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 12 ALA A 190
GLY A 204
ILE A 148
LEU A 167
VAL A 152
 None
 1.10A 3o7wA-1u5qA:
undetectable		 3o7wA-1u5qA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
VAL A  42
ALA A  55
LYS A  57
CYH A 108
GLY A 171
 None
 1.20A 3og7A-1u5qA:
24.5		 3og7A-1u5qA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
VAL A  42
ALA A  55
LYS A  57
CYH A 108
PHE A 170
 None
 1.06A 3og7A-1u5qA:
24.5		 3og7A-1u5qA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
LEU A  80
CYH A 108
PHE A 170
 None
 0.99A 3og7A-1u5qA:
24.5		 3og7A-1u5qA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A  80
ILE A  89
 None
 0.74A 3ohtA-1u5qA:
17.9		 3ohtA-1u5qA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
ILE A  89
 None
 0.54A 3ohtB-1u5qA:
17.8		 3ohtB-1u5qA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 VAL A  42
ALA A  55
GLU A  76
LEU A  80
ILE A  89
TYR A 107
LEU A 142
HIS A 149
 None
 0.72A 3rgfA-1u5qA:
23.1		 3rgfA-1u5qA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 12 THR A 132
GLY A 134
GLY A 138
PHE A 280
GLU A 125
 None
 1.37A 3tkaA-1u5qA:
undetectable		 3tkaA-1u5qA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
ASP A 169
 None
 0.80A 3v5wA-1u5qA:
10.3		 3v5wA-1u5qA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
GLU A  76
LEU A  80
CYH A 108
GLY A 110
 None
 0.67A 3wzdA-1u5qA:
23.5		 3wzdA-1u5qA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 110
LEU A 142
HIS A 149
 None
 0.68A 3wzeA-1u5qA:
23.4		 3wzeA-1u5qA:
25.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 12 ALA A  55
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 None
 0.48A 3zbfA-1u5qA:
25.6		 3zbfA-1u5qA:
32.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ALA A  55
LYS A  57
GLU A  76
LEU A 142
HIS A 149
ARG A 150
LEU A 158
 None
None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.79A 3zosA-1u5qA:
23.1		 3zosA-1u5qA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 ALA A  55
LYS A  57
GLU A  76
ILE A  89
LEU A 142
HIS A 149
ARG A 150
LEU A 158
 None
None
None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.77A 3zosB-1u5qA:
23.2		 3zosB-1u5qA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
GLU A  76
LEU A  80
GLY A 110
LEU A 158
 None
 0.56A 4agcA-1u5qA:
23.2		 4agcA-1u5qA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 110
LEU A 142
HIS A 149
 None
 0.66A 4asdA-1u5qA:
23.3		 4asdA-1u5qA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 5 LYS A  57
LEU A  83
TYR A 107
ARG A 150
 None
None
None
SEP  A 181 ( 2.8A)
 0.90A 4bkjB-1u5qA:
23.5		 4bkjB-1u5qA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 11 GLY A  35
VAL A  42
ALA A  55
TYR A 107
GLY A 110
SER A 111
LEU A 158
 None
 0.55A 4ckiA-1u5qA:
27.3		 4ckiA-1u5qA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 10 GLY A  35
GLY A  37
VAL A  42
ALA A  55
TYR A 107
SER A 111
LEU A 158
 None
 0.60A 4ckjA-1u5qA:
27.4		 4ckjA-1u5qA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A 103
MET A 105
GLY A 110
LEU A 158
 None
 0.76A 4i22A-1u5qA:
17.7		 4i22A-1u5qA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 VAL A  42
ALA A  55
ILE A  89
ASP A 151
LYS A 153
ASN A 156
LEU A 158
ASP A 169
 None
 0.84A 4i41A-1u5qA:
26.4		 4i41A-1u5qA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 7 VAL A  42
ALA A  55
MET A 105
LEU A 158
 None
 0.52A 4l9iA-1u5qA:
10.1		 4l9iA-1u5qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 8 GLY A  37
VAL A  42
ALA A  55
LYS A  57
MET A 105
 None
 0.42A 4l9iB-1u5qA:
27.7		 4l9iB-1u5qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 8 ILE A  34
VAL A  42
ALA A  55
ASN A 156
LEU A 158
ASP A 169
 None
 0.49A 4ogrA-1u5qA:
28.7		 4ogrA-1u5qA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 7 GLY A  35
ALA A  55
CYH A 108
ASN A 156
LEU A 158
ASP A 169
 None
 0.68A 4ogrE-1u5qA:
27.7		 4ogrE-1u5qA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 9 ILE A  34
VAL A  42
ALA A  55
CYH A 108
ASN A 156
LEU A 158
ASP A 169
 None
 0.53A 4ogrI-1u5qA:
28.5		 4ogrI-1u5qA:
29.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ILE A  34
ALA A  55
LYS A  57
GLU A  76
TYR A 107
LEU A 158
ASP A 169
 None
 0.76A 4qmnA-1u5qA:
36.5		 4qmnA-1u5qA:
39.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 11 ILE A  34
ALA A  55
GLU A  76
TYR A 107
LEU A 158
ASP A 169
 None
 0.72A 4qmsA-1u5qA:
36.6		 4qmsA-1u5qA:
39.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
LEU A 158
 None
 0.51A 4qmzA-1u5qA:
36.8		 4qmzA-1u5qA:
39.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
GLY A  35
VAL A  42
ALA A  55
TYR A 107
LEU A 158
 None
 0.41A 4qmzA-1u5qA:
36.8		 4qmzA-1u5qA:
39.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 8 VAL A  42
LYS A  57
ILE A  89
HIS A 149
LEU A 158
 None
 0.59A 4qrcA-1u5qA:
24.5		 4qrcA-1u5qA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ALA A  55
LYS A  57
GLU A  76
CYH A 108
LEU A 158
GLY A 168
ASP A 169
 None
 1.06A 4r7iA-1u5qA:
23.8		 4r7iA-1u5qA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
LEU A 158
GLY A 168
 None
 0.66A 4r7iA-1u5qA:
23.8		 4r7iA-1u5qA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 10 ILE A  34
ALA A  55
LYS A  57
ILE A  89
LEU A 158
 None
 0.61A 4rz7A-1u5qA:
9.7		 4rz7A-1u5qA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
CYH A 108
SER A 111
GLY A 168
GLY A 171
 None
 1.38A 4rzvB-1u5qA:
23.7		 4rzvB-1u5qA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
CYH A 108
SER A 111
GLY A 171
 None
 1.31A 4rzvB-1u5qA:
23.7		 4rzvB-1u5qA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ALA A  55
LYS A  57
LEU A  80
CYH A 108
GLY A 110
HIS A 149
LEU A 158
 None
 0.72A 4u0iA-1u5qA:
23.6		 4u0iA-1u5qA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 9 VAL A  42
LYS A  57
ILE A  89
TYR A 107
ARG A 150
LEU A 158
 None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.73A 4v01A-1u5qA:
23.6		 4v01A-1u5qA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 8 LYS A  57
ILE A  89
TYR A 107
LEU A 158
 None
 0.52A 4v04A-1u5qA:
23.6		 4v04A-1u5qA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 10 VAL A  42
LYS A  57
ILE A  89
TYR A 107
ARG A 150
LEU A 158
 None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.86A 4v04B-1u5qA:
24.1		 4v04B-1u5qA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
CYH A 108
GLY A 168
ASP A 169
PHE A 170
 None
 0.76A 4xv2A-1u5qA:
24.2		 4xv2A-1u5qA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
LYS A  57
CYH A 108
GLY A 168
ASP A 169
PHE A 170
 None
 0.93A 4xv2A-1u5qA:
24.2		 4xv2A-1u5qA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ALA A  55
LYS A  57
LEU A  80
CYH A 108
GLY A 168
ASP A 169
PHE A 170
 None
 0.92A 4xv2B-1u5qA:
24.5		 4xv2B-1u5qA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 9 VAL A  42
ALA A  55
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 None
 0.72A 5aaaA-1u5qA:
25.5		 5aaaA-1u5qA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 10 VAL A  42
ALA A  55
LYS A  57
GLY A 110
LEU A 158
GLY A 168
ASP A 169
 None
 0.84A 5aabA-1u5qA:
25.1		 5aabA-1u5qA:
29.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 10 ALA A  55
CYH A 108
GLY A 110
LEU A 158
ASP A 169
 None
 0.52A 5ajqB-1u5qA:
27.0		 5ajqB-1u5qA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
ILE A  89
TYR A 107
GLY A 110
LEU A 158
 None
 0.55A 5bvwA-1u5qA:
23.3		 5bvwA-1u5qA:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 VAL A  42
ALA A  55
LYS A  57
LEU A  80
CYH A 108
GLY A 168
PHE A 170
 None
 0.89A 5cswA-1u5qA:
24.1		 5cswA-1u5qA:
30.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
LEU A  80
CYH A 108
GLY A 168
 None
 0.83A 5cswB-1u5qA:
24.0		 5cswB-1u5qA:
30.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
LEU A  80
GLY A 168
PHE A 170
 None
 0.94A 5cswB-1u5qA:
24.0		 5cswB-1u5qA:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 VAL A  42
ALA A  55
ILE A  89
TYR A 107
PHE A 170
GLY A 171
 None
 1.15A 5hesA-1u5qA:
23.4		 5hesA-1u5qA:
26.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 ALA A  55
LYS A  57
GLU A  76
LEU A  80
CYH A 108
LEU A 142
HIS A 149
GLY A 168
 None
 0.73A 5hi2A-1u5qA:
24.4		 5hi2A-1u5qA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLY A 168
ASP A 169
 None
 0.87A 5hieC-1u5qA:
23.9		 5hieC-1u5qA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ILE A  34
ALA A  55
LYS A  57
GLU A  76
ILE A  89
TYR A 107
LEU A 158
 None
 0.86A 5i9xA-1u5qA:
24.7		 5i9xA-1u5qA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ILE A  34
ALA A  55
LYS A  57
ILE A  89
TYR A 107
GLY A 110
LEU A 158
 None
 0.68A 5i9xA-1u5qA:
24.7		 5i9xA-1u5qA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 12 LEU A 159
VAL A 131
GLY A 134
ALA A 135
LEU A 167
 None
 1.15A 5ikrA-1u5qA:
undetectable		 5ikrA-1u5qA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 7 GLY A  35
GLY A  37
SER A  38
GLY A  40
VAL A  42
 None
 0.64A 5izjB-1u5qA:
27.7		 5izjB-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 7 GLY A  35
GLY A  37
SER A  38
VAL A  42
LYS A  57
 None
 0.68A 5izjA-1u5qA:
28.0		 5izjA-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 7 GLY A  35
VAL A  42
LYS A  57
ASP A 169
 None
 0.46A 5j5xA-1u5qA:
28.1		 5j5xA-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 12 LEU A 164
LEU A 123
GLY A 110
ILE A 157
ALA A 154
 None
 1.04A 5j7wC-1u5qA:
undetectable		 5j7wC-1u5qA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 7 LEU A 218
ILE A 315
THR A 297
MET A 312
 None
 1.47A 5ljcA-1u5qA:
undetectable		 5ljcA-1u5qA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 9 ILE A  34
GLY A  35
VAL A  42
ALA A  55
ILE A  89
MET A 105
 None
 0.30A 5lw1B-1u5qA:
22.6		 5lw1B-1u5qA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 10 GLY A  35
VAL A  42
ALA A  55
ILE A  89
MET A 105
LEU A 158
 None
 1.46A 5lw1E-1u5qA:
22.3		 5lw1E-1u5qA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 ILE A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLU A  76
TYR A 107
GLY A 110
 None
 0.88A 5mafA-1u5qA:
27.2		 5mafA-1u5qA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 5 LEU A  80
CYH A 108
LEU A 158
ASP A 169
 None
 0.86A 5mafA-1u5qA:
27.2		 5mafA-1u5qA:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 8 ALA A  55
GLU A  76
CYH A 108
LEU A 158
ASP A 169
VAL A 301
 None
 0.49A 5owrA-1u5qA:
29.5		 5owrA-1u5qA:
33.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 7 ARG A 310
ALA A 300
ILE A 315
LEU A 316
 None
 0.73A 5te8C-1u5qA:
undetectable		 5te8C-1u5qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ALA A  55
GLU A  76
CYH A 108
GLY A 110
ASP A 114
ASP A 169
 None
 0.73A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ALA A  55
GLU A  76
TYR A 107
CYH A 108
GLY A 110
ASP A 169
 None
 0.62A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
ALA A  55
GLU A  76
CYH A 108
GLY A 110
ASP A 114
 None
 1.08A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
ALA A  55
GLU A  76
TYR A 107
CYH A 108
GLY A 110
 None
 0.97A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
GLY A  35
ALA A  55
CYH A 108
GLY A 110
ASP A 114
 None
 0.91A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ILE A  34
GLY A  35
ALA A  55
TYR A 107
CYH A 108
GLY A 110
 None
 0.62A 5vc3A-1u5qA:
26.4		 5vc3A-1u5qA:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 ALA A  55
LYS A  57
GLU A  76
LEU A 103
GLY A 110
GLY A 168
 None
 0.93A 5vcvA-1u5qA:
27.2		 5vcvA-1u5qA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A 103
CYH A 108
GLY A 110
 None
 1.10A 5vcyA-1u5qA:
27.3		 5vcyA-1u5qA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		5 / 12 LEU A 103
PHE A  39
HIS A 149
THR A 185
GLY A 184
 None
 1.32A 5xiqD-1u5qA:
undetectable		 5xiqD-1u5qA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
 None
 0.61A 5y7zA-1u5qA:
25.7		 5y7zA-1u5qA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
 None
 0.61A 5y7zA-1u5qA:
25.7		 5y7zA-1u5qA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		7 / 12 ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
ASP A 169
 None
 0.59A 5y7zB-1u5qA:
17.9		 5y7zB-1u5qA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
ASP A 169
 None
 0.55A 5y80A-1u5qA:
24.4		 5y80A-1u5qA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		6 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A 103
MET A 105
 None
 0.83A 5yu9B-1u5qA:
22.3		 5yu9B-1u5qA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		4 / 7 VAL A  42
LYS A  57
ILE A  89
ASP A 169
 None
 0.55A 5ywmX-1u5qA:
24.6		 5ywmX-1u5qA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		3 / 3 TYR A 107
LEU A 158
ASP A 169
 None
 0.83A 5zv2B-1u5qA:
23.9		 5zv2B-1u5qA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1u5q SERINE/THREONINE
PROTEIN KINASE TAO2
(Rattus
norvegicus) 		8 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
ILE A  89
TYR A 107
GLY A 110
LEU A 158
 None
 0.54A 6bsdA-1u5qA:
23.1		 6bsdA-1u5qA:
13.64