SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1u5s PINCH PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 103
ILE B  86
LYS B  96
ALA B  93
 None
 1.07A 1hk2A-1u5sB:
undetectable		 1hk2A-1u5sB:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1u5s CYTOPLASMIC PROTEIN
NCK2
PINCH PROTEIN
(Homo
sapiens) 		3 / 3 VAL B 104
VAL B 100
ASP A  66
 None
 0.74A 2fumD-1u5sB:
undetectable		 2fumD-1u5sB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 1u5s CYTOPLASMIC PROTEIN
NCK2
(Homo
sapiens) 		4 / 5 ALA A  49
GLY A  54
CYH A  46
LYS A  45
 None
 1.33A 2yldA-1u5sA:
undetectable		 2yldA-1u5sA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 1u5s CYTOPLASMIC PROTEIN
NCK2
(Homo
sapiens) 		4 / 5 ALA A  49
GLY A  54
CYH A  46
LYS A  45
 None
 1.44A 2ylgA-1u5sA:
undetectable		 2ylgA-1u5sA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1u5s CYTOPLASMIC PROTEIN
NCK2
(Homo
sapiens) 		4 / 7 TRP A  43
GLU A  22
GLU A  21
GLU A  20
 None
 1.44A 4r87J-1u5sA:
undetectable
4r87L-1u5sA:
undetectable		 4r87J-1u5sA:
17.78
4r87L-1u5sA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 1u5s CYTOPLASMIC PROTEIN
NCK2
(Homo
sapiens) 		4 / 5 ALA A  49
GLY A  54
CYH A  46
LYS A  45
 None
 1.38A 5jliA-1u5sA:
undetectable		 5jliA-1u5sA:
18.85