SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1u5t DEFECTIVE IN
VACUOLAR PROTEIN
SORTING
VPS36P
(Saccharomyces
cerevisiae) 		5 / 11 SER B 489
VAL B 487
ILE B 435
LEU B 440
LEU B 420
 None
 1.21A 2a15A-1u5tB:
undetectable		 2a15A-1u5tB:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 1u5t VPS36P
DEFECTIVE IN
VACUOLAR PROTEIN
SORTING
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 440
LEU B 420
MET B 448
THR B 528
 None
 1.43A 2oaxD-1u5tB:
0.0		 2oaxD-1u5tB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1u5t VPS36P
DEFECTIVE IN
VACUOLAR PROTEIN
SORTING
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 432
ILE B 434
LEU B 518
LEU B 514
 None
 0.89A 2vctA-1u5tB:
undetectable		 2vctA-1u5tB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 1u5t DEFECTIVE IN
VACUOLAR PROTEIN
SORTING
VPS36P
(Saccharomyces
cerevisiae) 		5 / 11 ILE B 435
ASP B 439
ILE B 531
GLY B 530
VAL B 495
 None
 1.00A 4ac9B-1u5tB:
undetectable
4ac9C-1u5tB:
undetectable		 4ac9B-1u5tB:
17.90
4ac9C-1u5tB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1u5t DEFECTIVE IN
VACUOLAR PROTEIN
SORTING
VPS36P
(Saccharomyces
cerevisiae) 		4 / 8 ASP B 439
ILE B 531
GLY B 530
VAL B 495
 None
 0.89A 4acbB-1u5tB:
undetectable
4acbC-1u5tB:
undetectable		 4acbB-1u5tB:
17.90
4acbC-1u5tB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1u5t VPS36P
DEFECTIVE IN
VACUOLAR PROTEIN
SORTING
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 435
THR B 528
VAL B 478
ASP B 493
 None
 1.23A 4iarA-1u5tB:
undetectable		 4iarA-1u5tB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1u5t VPS36P
DEFECTIVE IN
VACUOLAR PROTEIN
SORTING
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 475
VAL B 487
ILE B 435
MET B 460
 None
 0.76A 4oj4A-1u5tB:
undetectable		 4oj4A-1u5tB:
22.83