SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 10 ALA A  99
LEU A 271
ALA A 304
PHE A 322
ILE A 121
 None
None
None
HEM  A 999 (-4.5A)
None
 1.25A 1g5yC-1u5uA:
undetectable		 1g5yC-1u5uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ALA A 162
LEU A 180
ASP A 115
LEU A 106
 None
 0.90A 1mt1D-1u5uA:
0.0
1mt1E-1u5uA:
0.0		 1mt1D-1u5uA:
13.37
1mt1E-1u5uA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 178
ASN A   5
TRP A   3
 None
 1.12A 1r15D-1u5uA:
undetectable		 1r15D-1u5uA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 178
ASN A   5
TRP A   3
 None
 1.10A 1r15E-1u5uA:
undetectable		 1r15E-1u5uA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 178
ASN A   5
TRP A   3
 None
 1.11A 1r15F-1u5uA:
undetectable		 1r15F-1u5uA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 ASP A 302
ASP A  82
PRO A  86
ASP A 204
ALA A 202
 None
 1.41A 1s14B-1u5uA:
undetectable		 1s14B-1u5uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 SER A 227
GLY A 228
ARG A 249
 None
 0.45A 1t9wA-1u5uA:
0.0		 1t9wA-1u5uA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 LEU A 101
ILE A 121
PHE A 322
HIS A 103
 None
None
HEM  A 999 (-4.5A)
None
 0.89A 2azxA-1u5uA:
undetectable		 2azxA-1u5uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLU A 140
ILE A  24
LEU A  20
ASN A   5
ARG A 229
 None
 1.26A 2e7fA-1u5uA:
undetectable		 2e7fA-1u5uA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLU A 140
ILE A  24
LEU A  20
ASN A   5
ARG A 229
 None
 1.20A 2e7fB-1u5uA:
undetectable		 2e7fB-1u5uA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 226
GLU A 223
TRP A   3
 None
 1.33A 3hrdA-1u5uA:
undetectable
3hrdE-1u5uA:
undetectable
3hrdF-1u5uA:
undetectable		 3hrdA-1u5uA:
21.52
3hrdE-1u5uA:
21.52
3hrdF-1u5uA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 226
LEU A 190
LEU A 271
 None
 0.73A 3ohtA-1u5uA:
undetectable		 3ohtA-1u5uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 226
LEU A 190
LEU A 271
 None
 0.74A 3ohtB-1u5uA:
undetectable		 3ohtB-1u5uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 TYR A 353
PHE A 144
ARG A 349
 HEM  A 999 (-3.8A)
HEM  A 999 (-4.5A)
HEM  A 999 (-3.4A)
 1.22A 4g19D-1u5uA:
undetectable		 4g19D-1u5uA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 ALA A 304
ILE A  77
PHE A  91
PRO A 131
LEU A 331
 None
 1.01A 4m2xA-1u5uA:
undetectable		 4m2xA-1u5uA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 ILE A 273
ALA A 304
ILE A  77
PHE A  91
PRO A 131
 None
 1.01A 4m2xA-1u5uA:
undetectable		 4m2xA-1u5uA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 ILE A 273
ALA A 304
ILE A  77
PRO A 131
LEU A 331
 None
 1.03A 4m2xC-1u5uA:
undetectable		 4m2xC-1u5uA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 ARG A 243
ASP A 110
TYR A 253
 None
 0.61A 4yo9B-1u5uA:
undetectable		 4yo9B-1u5uA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 GLU A 178
ARG A 229
GLU A 226
TYR A 193
 None
 1.07A 4zz8A-1u5uA:
undetectable		 4zz8A-1u5uA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 TYR A 171
ILE A 143
GLY A 139
LEU A 292
 None
 0.93A 5esfA-1u5uA:
undetectable		 5esfA-1u5uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLY A  39
LYS A  41
ASN A 343
LEU A 333
GLU A 335
 None
 1.15A 5nwwA-1u5uA:
undetectable		 5nwwA-1u5uA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 LEU A 348
LYS A  45
LEU A 150
GLU A 151
 HEM  A 999 ( 4.5A)
None
HEM  A 999 ( 4.3A)
None
 0.86A 5weaA-1u5uA:
undetectable		 5weaA-1u5uA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 TYR A 173
ALA A 179
LEU A 180
 None
 0.65A 6ag0C-1u5uA:
undetectable		 6ag0C-1u5uA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 ARG A 270
LYS A 222
TYR A 191
 None
 1.16A 6gnaA-1u5uA:
undetectable		 6gnaA-1u5uA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 ARG A 270
LYS A 222
TYR A 191
 None
 1.16A 6gnbA-1u5uA:
undetectable		 6gnbA-1u5uA:
23.04