SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 149
ALA A 136
ALA A 180
GLU A 194
 None
 1.17A 1e7bA-1u5vA:
undetectable		 1e7bA-1u5vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 149
ALA A 136
ALA A 180
GLU A 194
 None
 1.11A 1e7bB-1u5vA:
undetectable		 1e7bB-1u5vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 149
ALA A 136
ALA A 180
GLU A 194
 None
 1.06A 1e7cA-1u5vA:
undetectable		 1e7cA-1u5vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1u5v CITE
(Mycobacterium
tuberculosis) 		5 / 12 SER A 148
TYR A 155
VAL A 207
ALA A 180
HIS A 182
 None
 1.33A 1q23D-1u5vA:
undetectable
1q23E-1u5vA:
undetectable		 1q23D-1u5vA:
21.18
1q23E-1u5vA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A  62
THR A  87
VAL A 130
GLY A 131
 None
 0.99A 2p2fA-1u5vA:
undetectable		 2p2fA-1u5vA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A  62
THR A  87
VAL A 130
GLY A 131
 None
 0.98A 2p2fB-1u5vA:
2.1		 2p2fB-1u5vA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1u5v CITE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  91
LEU A  90
ARG A 105
 None
 0.79A 3aqiB-1u5vA:
undetectable		 3aqiB-1u5vA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  34
ASP A  72
GLU A 112
ASP A  76
 None
 1.18A 4gkiC-1u5vA:
undetectable		 4gkiC-1u5vA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 166
ARG A 163
GLY A 135
VAL A 181
 None
 0.90A 4oltA-1u5vA:
undetectable		 4oltA-1u5vA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 166
ARG A 163
GLY A 135
VAL A 181
 None
 0.92A 4oltB-1u5vA:
undetectable		 4oltB-1u5vA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1u5v CITE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 183
ASP A 187
ILE A 140
 None
 0.65A 4xi3D-1u5vA:
undetectable		 4xi3D-1u5vA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 5 CYH A 208
ILE A 185
LEU A  11
HIS A 210
 None
 1.40A 5hrqC-1u5vA:
undetectable
5hrqD-1u5vA:
undetectable
5hrqL-1u5vA:
undetectable		 5hrqC-1u5vA:
3.75
5hrqD-1u5vA:
7.97
5hrqL-1u5vA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 1u5v CITE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  74
ASP A  72
ASP A  76
ILE A  65
GLY A  68
 None
 1.23A 5kr2A-1u5vA:
undetectable		 5kr2A-1u5vA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1u5v CITE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  39
ASP A  37
LEU A  80
LEU A  51
ALA A  15
 None
 1.08A 5nd7B-1u5vA:
undetectable		 5nd7B-1u5vA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1u5v CITE
(Mycobacterium
tuberculosis) 		5 / 9 HIS A 161
ILE A 108
LEU A 176
ARG A 163
ASP A 179
 None
 1.14A 6c2mC-1u5vA:
undetectable		 6c2mC-1u5vA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1u5v CITE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  56
THR A  83
VAL A  63
LEU A  33
 None
 0.70A 6czmD-1u5vA:
undetectable
6czmF-1u5vA:
undetectable		 6czmD-1u5vA:
22.65
6czmF-1u5vA:
22.65