SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 LEU A 212
GLY A 258
ALA A 268
GLY A 265
LEU A 205
 None
 1.02A 1fe2A-1u60A:
undetectable		 1fe2A-1u60A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		6 / 12 SER A  66
LYS A  69
ASN A 117
LYS A 259
SER A 260
GLY A 261
 None
 0.69A 1ghmA-1u60A:
4.6		 1ghmA-1u60A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 LEU A 212
GLY A 258
ALA A 268
GLY A 265
LEU A 205
 None
 0.98A 1igxA-1u60A:
undetectable		 1igxA-1u60A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		4 / 4 SER A 260
LEU A 115
TYR A 244
GLY A 258
 None
 1.31A 1liiA-1u60A:
undetectable		 1liiA-1u60A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 11 LEU A 205
GLY A 265
GLY A 264
LEU A 283
LEU A  64
 None
None
None
FMT  A1212 ( 4.5A)
None
 0.73A 1mx1A-1u60A:
undetectable		 1mx1A-1u60A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 LEU A 205
GLY A 265
GLY A 264
LEU A 283
LEU A  64
 None
None
None
FMT  A1212 ( 4.5A)
None
 0.74A 1mx1D-1u60A:
undetectable		 1mx1D-1u60A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		4 / 8 SER A 160
THR A 163
ASN A 158
GLU A 133
 None
 0.91A 1mxgA-1u60A:
undetectable		 1mxgA-1u60A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 11 LEU A 115
GLY A 258
ILE A 234
TYR A 233
PRO A  82
 None
 1.21A 1p91A-1u60A:
undetectable		 1p91A-1u60A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 GLY A 261
GLY A 263
ALA A  27
TYR A 244
SER A  66
 None
 0.94A 1ri4A-1u60A:
undetectable		 1ri4A-1u60A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 10 LEU A 283
GLY A 263
TYR A 244
LEU A  33
ILE A  67
 FMT  A1212 ( 4.5A)
None
None
None
None
 1.35A 1sq5B-1u60A:
undetectable		 1sq5B-1u60A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 LEU A 212
GLY A 258
PRO A 257
ILE A 234
VAL A  70
 None
 0.98A 1tmxB-1u60A:
undetectable		 1tmxB-1u60A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 LEU A  64
ILE A 203
GLY A 265
VAL A  52
LEU A 220
 None
EDO  A1217 ( 3.8A)
None
None
None
 0.78A 1vptA-1u60A:
undetectable		 1vptA-1u60A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 GLY A 265
GLY A 264
GLY A 263
LEU A  64
SER A 280
 None
 0.89A 1xdsA-1u60A:
undetectable		 1xdsA-1u60A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 GLY A 265
GLY A 264
GLY A 263
LEU A  64
SER A 280
 None
 0.87A 1xdsB-1u60A:
undetectable		 1xdsB-1u60A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 GLY A  56
VAL A  11
ALA A  44
ASP A  57
ALA A  42
 None
None
None
EDO  A1219 ( 4.8A)
None
 1.40A 2avdB-1u60A:
undetectable		 2avdB-1u60A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 9 ALA A  55
ALA A  41
PHE A  62
GLY A 265
SER A  58
 None
 1.24A 2vh3A-1u60A:
0.0		 2vh3A-1u60A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		4 / 8 GLY A 209
ILE A 266
MET A 238
ALA A 147
 None
 0.85A 2x0pA-1u60A:
undetectable		 2x0pA-1u60A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 GLY A 264
ILE A 266
SER A 260
ASN A  26
LEU A 283
 None
None
None
None
FMT  A1212 ( 4.5A)
 0.91A 3cjtK-1u60A:
undetectable		 3cjtK-1u60A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		6 / 12 ALA A  27
SER A 280
PRO A 281
GLY A 264
GLY A 263
LEU A  21
 None
 1.35A 3douA-1u60A:
undetectable		 3douA-1u60A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 VAL A  52
SER A  54
GLY A 275
ALA A 206
LEU A 220
 None
 1.02A 3hs6A-1u60A:
0.0		 3hs6A-1u60A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 10 VAL A 269
GLY A 258
VAL A  46
ILE A  67
GLY A 209
 None
 1.33A 3km6A-1u60A:
undetectable		 3km6A-1u60A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 9 ASN A 168
ALA A 172
LEU A 175
ALA A 188
SER A 125
 None
 1.16A 3kp6B-1u60A:
undetectable		 3kp6B-1u60A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		4 / 6 ILE A 121
ALA A 122
ALA A  76
THR A  72
 None
 1.06A 3mdrB-1u60A:
undetectable		 3mdrB-1u60A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 GLY A 261
VAL A  70
LEU A 208
THR A 202
PHE A  62
 None
 1.42A 3mnoA-1u60A:
undetectable		 3mnoA-1u60A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 PHE A  18
ALA A 278
MET A 295
ALA A 300
LEU A 256
 None
 0.90A 4oaeA-1u60A:
undetectable		 4oaeA-1u60A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		3 / 3 ARG A 194
GLN A 137
GLU A 133
 None
 0.93A 4tvtA-1u60A:
undetectable		 4tvtA-1u60A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 10 ILE A 142
LEU A 226
VAL A 269
LEU A 267
PRO A 257
 None
 1.18A 5ienB-1u60A:
undetectable		 5ienB-1u60A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 LEU A   2
THR A  47
ILE A  45
GLY A 275
ILE A 276
 None
 1.23A 5ifuA-1u60A:
undetectable		 5ifuA-1u60A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 GLY A 245
ALA A 103
LEU A 104
SER A 113
PRO A 111
 None
 1.34A 5jglB-1u60A:
undetectable		 5jglB-1u60A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 GLY A 265
ALA A 147
LEU A 146
ALA A  63
SER A  68
 None
 1.20A 5jglB-1u60A:
undetectable		 5jglB-1u60A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 10 ASP A  59
ALA A  44
SER A  54
THR A 211
LEU A 220
 EDO  A1217 (-3.5A)
None
None
None
None
 1.25A 5m5cE-1u60A:
undetectable		 5m5cE-1u60A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 12 MET A 238
GLY A 261
SER A  66
GLU A  65
PHE A  62
 None
 1.42A 5vlmF-1u60A:
undetectable		 5vlmF-1u60A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1u60 PROBABLE GLUTAMINASE
YBAS
(Escherichia
coli) 		5 / 9 ALA A  74
GLU A  78
LEU A 226
GLY A 209
LEU A 208
 None
 1.38A 5wgqA-1u60A:
undetectable		 5wgqA-1u60A:
12.17