SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 ALA C 198
ILE C 211
LEU C 215
ILE C 237
THR C 195
 None
 1.11A 1d1gA-1u6gC:
undetectable		 1d1gA-1u6gC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		6 / 12 ALA C 198
LEU C 177
ILE C 211
LEU C 215
ILE C 237
THR C 195
 None
 1.29A 1dhjA-1u6gC:
undetectable		 1dhjA-1u6gC:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 4 THR C 611
LEU C 612
VAL C 647
LEU C 648
 None
 0.91A 1fbmB-1u6gC:
0.0		 1fbmB-1u6gC:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 4 THR C 611
LEU C 612
VAL C 647
LEU C 648
 None
 0.92A 1fbmD-1u6gC:
undetectable		 1fbmD-1u6gC:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 5 THR C 611
LEU C 612
VAL C 647
LEU C 648
 None
 0.84A 1fbmE-1u6gC:
undetectable		 1fbmE-1u6gC:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 GLN C 544
ILE C 473
HIS C 516
 None
 0.76A 1fm9A-1u6gC:
0.0		 1fm9A-1u6gC:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 7 LEU C 851
GLY C 853
LEU C 855
LYS C 858
 None
 0.91A 1gtiD-1u6gC:
2.9		 1gtiD-1u6gC:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 7 LEU C 851
GLY C 853
LEU C 855
LYS C 858
 None
 0.91A 1gtiE-1u6gC:
2.6		 1gtiE-1u6gC:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 10 PHE C 715
ILE C 676
LEU C 655
LEU C 619
ILE C 635
 None
 1.38A 1i18A-1u6gC:
undetectable
1i18B-1u6gC:
undetectable		 1i18A-1u6gC:
6.76
1i18B-1u6gC:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 GLN C 544
ILE C 473
HIS C 516
 None
 0.74A 1k74A-1u6gC:
0.0		 1k74A-1u6gC:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 4 THR C 611
LEU C 612
VAL C 647
LEU C 648
 None
 0.85A 1mz9D-1u6gC:
undetectable		 1mz9D-1u6gC:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 4 ALA C 805
VAL C 803
ALA C 804
HIS C 848
 None
 1.20A 1q23K-1u6gC:
undetectable		 1q23K-1u6gC:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 ASP C 344
LYS C 348
ARG C 351
 None
 0.69A 1ra8A-1u6gC:
undetectable		 1ra8A-1u6gC:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 10 ALA C 198
LEU C 177
ILE C 211
ILE C 237
THR C 195
 None
 1.24A 1rb3A-1u6gC:
undetectable		 1rb3A-1u6gC:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		6 / 12 ALA C 198
LEU C 177
ILE C 211
LEU C 215
ILE C 237
THR C 195
 None
 1.26A 1rd7A-1u6gC:
undetectable		 1rd7A-1u6gC:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 LYS C  48
ILE C  53
THR C  86
 None
 0.84A 1rx3A-1u6gC:
undetectable		 1rx3A-1u6gC:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 4 LYS C 801
LEU C 752
LEU C 747
SER C 744
 None
 1.33A 1tt6A-1u6gC:
0.0		 1tt6A-1u6gC:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 4 ASP C 824
LEU C 840
LEU C 837
LEU C 839
 None
 1.40A 1u18A-1u6gC:
0.0		 1u18A-1u6gC:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 7 MET C 158
ALA C 154
ILE C 142
ILE C 176
 None
 0.66A 1upfB-1u6gC:
undetectable		 1upfB-1u6gC:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 11 ILE C1081
ALA C1084
ALA C1085
ASN C1054
LEU C1052
 None
 0.95A 2aclE-1u6gC:
undetectable		 2aclE-1u6gC:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 8 SER C 557
PHE C 559
LEU C 546
LEU C 568
 None
 0.87A 2bfpC-1u6gC:
undetectable		 2bfpC-1u6gC:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 8 LEU C 892
ILE C 932
ILE C 916
ILE C 917
 None
 0.74A 2bu8A-1u6gC:
2.0		 2bu8A-1u6gC:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 11 VAL C 528
GLY C 529
ALA C 539
LEU C 540
ARG C 588
 None
 1.25A 2bxgA-1u6gC:
2.4		 2bxgA-1u6gC:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		6 / 12 ALA C 198
LEU C 177
ILE C 211
LEU C 215
ILE C 237
THR C 195
 None
 1.30A 2drcB-1u6gC:
undetectable		 2drcB-1u6gC:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 11 LEU C 896
LEU C 892
VAL C 885
ILE C 932
LEU C 958
 None
 1.25A 2q6hA-1u6gC:
undetectable		 2q6hA-1u6gC:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 10 ILE C 932
LEU C 970
LEU C 958
GLY C 956
ALA C 988
 None
 1.22A 2xf3A-1u6gC:
undetectable		 2xf3A-1u6gC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 ARG C1174
GLU C1165
SER C1204
 None
 0.83A 2xkkA-1u6gC:
undetectable
2xkkC-1u6gC:
undetectable		 2xkkA-1u6gC:
21.84
2xkkC-1u6gC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 5 SER C 163
LEU C 117
GLY C 115
CYH C 131
 None
 1.18A 3aiaA-1u6gC:
undetectable
3aiaB-1u6gC:
undetectable		 3aiaA-1u6gC:
11.40
3aiaB-1u6gC:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 ALA C 754
GLY C 750
HIS C 707
LEU C 756
MET C 711
 None
 1.47A 3bxoB-1u6gC:
undetectable		 3bxoB-1u6gC:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		6 / 12 ALA C 198
LEU C 177
ILE C 211
LEU C 215
ILE C 237
THR C 195
 None
 1.28A 3drcB-1u6gC:
undetectable		 3drcB-1u6gC:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 8 LEU C  54
VAL C  69
LEU C  72
ILE C 105
LEU C  91
 None
 1.07A 3kp6A-1u6gC:
undetectable
3kp6B-1u6gC:
undetectable		 3kp6A-1u6gC:
9.65
3kp6B-1u6gC:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 8 LEU C 102
VAL C  69
LEU C  57
ILE C 108
LEU C  91
 None
 1.38A 3kp6A-1u6gC:
undetectable
3kp6B-1u6gC:
undetectable		 3kp6A-1u6gC:
9.65
3kp6B-1u6gC:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 7 LEU C 214
LEU C 162
ARG C 244
ILE C 237
 None
 0.94A 3ln1B-1u6gC:
undetectable		 3ln1B-1u6gC:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 HIS C 848
ARG C 808
GLU C 844
 None
 0.93A 3qf1A-1u6gC:
undetectable		 3qf1A-1u6gC:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 6 PHE C 715
LEU C 685
ALA C 720
LEU C 694
 None
 0.99A 3t3zD-1u6gC:
undetectable		 3t3zD-1u6gC:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 8 ILE C1008
ILE C 993
THR C1091
VAL C1048
 None
 0.82A 3ua5A-1u6gC:
undetectable		 3ua5A-1u6gC:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 LYS C  48
ILE C  53
THR C  86
 None
 0.85A 4gh8A-1u6gC:
undetectable		 4gh8A-1u6gC:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 LYS C 577
ILE C 581
THR C 624
 None
 0.87A 4gh8A-1u6gC:
undetectable		 4gh8A-1u6gC:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 ASN C 463
VAL C 464
LEU C 476
ALA C 468
ASN C 507
 None
 1.33A 4qckA-1u6gC:
undetectable		 4qckA-1u6gC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 7 PHE C 759
LEU C 762
LEU C 735
ILE C 739
 None
 0.86A 4rmjA-1u6gC:
undetectable		 4rmjA-1u6gC:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 VAL C1022
LEU C1015
VAL C 986
 None
 0.63A 4wq4A-1u6gC:
undetectable		 4wq4A-1u6gC:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 8 GLY C 749
GLN C 748
SER C 753
SER C 798
 None
 1.00A 4ws1A-1u6gC:
undetectable		 4ws1A-1u6gC:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 VAL C  79
LEU C  91
ILE C  87
LYS C  80
VAL C  69
 None
 1.13A 4y0qA-1u6gC:
undetectable		 4y0qA-1u6gC:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 LEU C1093
PHE C1030
LEU C1052
TYR C1053
LEU C1100
 None
 1.08A 5dbyA-1u6gC:
2.4		 5dbyA-1u6gC:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 9 ALA C  68
LEU C  75
GLY C  73
LEU C  72
LEU C  57
 None
 1.20A 5dqfA-1u6gC:
undetectable		 5dqfA-1u6gC:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 ASP C 774
VAL C 763
LEU C 806
 None
 0.58A 5e5jB-1u6gC:
undetectable		 5e5jB-1u6gC:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 5 PRO C 377
THR C 405
GLN C 431
THR C 426
 None
 1.27A 5h5fA-1u6gC:
undetectable		 5h5fA-1u6gC:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 LEU C 181
LEU C 199
ARG C 228
 None
 0.47A 5hnzB-1u6gC:
2.3		 5hnzB-1u6gC:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 LEU C 461
LEU C 469
ARG C 451
 None
 0.56A 5hnzB-1u6gC:
2.3		 5hnzB-1u6gC:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 4 CYH C 527
LEU C 484
LEU C 498
ALA C 497
 None
 1.09A 5hpuA-1u6gC:
undetectable
5hpuB-1u6gC:
undetectable		 5hpuA-1u6gC:
3.59
5hpuB-1u6gC:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_B_ACTB805_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT
ACETONE CARBOXYLASE
BETA SUBUNIT)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 5 VAL C  88
GLU C  85
ARG C 137
LYS C 133
 None
 1.49A 5m45A-1u6gC:
0.0
5m45B-1u6gC:
1.0		 5m45A-1u6gC:
21.42
5m45B-1u6gC:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_K_ACTK805_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT
ACETONE CARBOXYLASE
BETA SUBUNIT)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 4 VAL C  88
GLU C  85
ARG C 137
LYS C 133
 None
 1.37A 5m45J-1u6gC:
0.0
5m45K-1u6gC:
0.6		 5m45J-1u6gC:
21.42
5m45K-1u6gC:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 ILE C 701
ILE C 690
VAL C 693
LEU C 694
ILE C 730
 None
 0.87A 5mueA-1u6gC:
undetectable		 5mueA-1u6gC:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 6 LEU C 752
SER C 753
ASP C 757
HIS C 848
 None
 0.77A 5om3A-1u6gC:
0.0
5om3B-1u6gC:
0.0		 5om3A-1u6gC:
5.34
5om3B-1u6gC:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 LEU C 716
LEU C 719
ALA C 720
LEU C 727
ILE C 701
 None
 0.86A 5toaA-1u6gC:
undetectable		 5toaA-1u6gC:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		4 / 6 LEU C1004
LEU C1040
LEU C1045
GLU C1016
 None
 0.98A 5tudD-1u6gC:
undetectable		 5tudD-1u6gC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 GLU C 737
GLY C 740
LEU C 770
GLY C 732
ILE C 734
 None
 1.12A 5vopB-1u6gC:
undetectable		 5vopB-1u6gC:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 ALA C 816
PHE C 821
VAL C 803
GLY C 843
ALA C 879
 None
 1.02A 5x23A-1u6gC:
undetectable		 5x23A-1u6gC:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 LEU C 218
GLY C 200
LEU C 155
ILE C 196
LEU C 169
 None
 1.16A 5y2tA-1u6gC:
undetectable		 5y2tA-1u6gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 GLN C 544
ILE C 473
HIS C 516
 None
 0.70A 5z12B-1u6gC:
undetectable		 5z12B-1u6gC:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		5 / 12 ILE C 799
ILE C 739
LEU C 776
ALA C 805
LEU C 806
 None
 0.80A 6ajiA-1u6gC:
1.3		 6ajiA-1u6gC:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 LEU C 655
ASN C 680
LEU C 685
 None
 0.66A 6exiA-1u6gC:
undetectable		 6exiA-1u6gC:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 LEU C 896
ASN C 887
LEU C 880
 None
 0.71A 6exiA-1u6gC:
undetectable		 6exiA-1u6gC:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1u6g TIP120 PROTEIN
(Homo
sapiens) 		3 / 3 THR C1091
GLU C1016
ASN C1031
 None
 0.68A 6nj9K-1u6gC:
undetectable		 6nj9K-1u6gC:
15.13