SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.25A 1d1gA-1u6mA:
undetectable		 1d1gA-1u6mA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 10 ALA A   7
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.19A 1j3jA-1u6mA:
0.0		 1j3jA-1u6mA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 9 ALA A   7
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.23A 1j3jB-1u6mA:
undetectable		 1j3jB-1u6mA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 GLU A  67
ARG A 123
ILE A 129
GLU A  63
ARG A   5
 None
 1.32A 1l7fA-1u6mA:
undetectable		 1l7fA-1u6mA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 6 LEU A 102
GLU A 105
THR A  51
TYR A  52
 None
 1.11A 1qvuA-1u6mA:
0.0		 1qvuA-1u6mA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 8 ASN A 152
GLU A 112
HIS A 184
ALA A  77
 None
 1.02A 2bnnA-1u6mA:
undetectable
2bnnB-1u6mA:
undetectable		 2bnnA-1u6mA:
22.27
2bnnB-1u6mA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 8 LEU A 149
ASN A 152
HIS A 184
GLU A 112
 None
 1.03A 2bnnA-1u6mA:
undetectable
2bnnB-1u6mA:
undetectable		 2bnnA-1u6mA:
22.27
2bnnB-1u6mA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ILE A  71
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.25A 3clbA-1u6mA:
undetectable		 3clbA-1u6mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ILE A  71
ILE A 129
PHE A 124
ILE A   4
 None
 1.23A 3clbB-1u6mA:
undetectable		 3clbB-1u6mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ILE A  71
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.21A 3clbC-1u6mA:
undetectable		 3clbC-1u6mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		6 / 10 ALA A   7
ILE A  71
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.15A 3clbD-1u6mA:
0.0		 3clbD-1u6mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ILE A  71
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.21A 3hbbC-1u6mA:
undetectable		 3hbbC-1u6mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		6 / 10 ALA A   7
ILE A  71
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.16A 3hbbD-1u6mA:
undetectable		 3hbbD-1u6mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 10 ALA A   7
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.23A 3qgtA-1u6mA:
undetectable		 3qgtA-1u6mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 10 ALA A   7
ASP A  11
ILE A 129
ILE A   4
THR A   8
 None
 1.25A 3qgtB-1u6mA:
undetectable		 3qgtB-1u6mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 8 ALA A  16
VAL A  19
LEU A  23
LEU A  42
 None
 0.58A 3roxA-1u6mA:
undetectable		 3roxA-1u6mA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 12 GLU A  67
ARG A 123
ILE A 129
GLU A  63
ARG A   5
 None
 1.33A 4mwvA-1u6mA:
undetectable		 4mwvA-1u6mA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 7 ILE A 129
GLY A 128
PHE A 169
ASP A 135
 None
SO4  A1003 ( 4.3A)
None
None
 0.57A 5hieA-1u6mA:
undetectable		 5hieA-1u6mA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 8 ILE A 129
GLY A 128
PHE A 169
ASP A 135
 None
SO4  A1003 ( 4.3A)
None
None
 0.46A 5hieD-1u6mA:
undetectable		 5hieD-1u6mA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 10 SER A 119
GLY A  70
ALA A   7
VAL A  61
ASP A 121
 None
 1.03A 5i3cB-1u6mA:
undetectable		 5i3cB-1u6mA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		5 / 11 SER A 119
GLY A  70
ALA A   7
VAL A  61
ASP A 121
 None
 1.15A 5i3cC-1u6mA:
undetectable		 5i3cC-1u6mA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 1u6m ACETYLTRANSFERASE,
GNAT FAMILY
(Enterococcus
faecalis) 		4 / 4 PRO A  29
LEU A  31
VAL A 100
ARG A 101
 None
 1.28A 6fgdA-1u6mA:
0.0		 6fgdA-1u6mA:
20.52