SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 11 PRO A  35
ASP A  53
TYR A  19
TYR A  38
HIS A  25
 None
 1.43A 1e7wB-1u6rA:
undetectable		 1e7wB-1u6rA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 8 ALA A  75
LEU A  87
HIS A  96
LEU A 286
 None
 0.92A 1ereE-1u6rA:
undetectable		 1ereE-1u6rA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 8 ALA A  75
LEU A  87
HIS A  96
LEU A 286
 None
 0.91A 1ereF-1u6rA:
undetectable		 1ereF-1u6rA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 6 PRO A 143
MET A 206
GLU A 230
GLU A 231
 None
 1.37A 1qhyA-1u6rA:
undetectable		 1qhyA-1u6rA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG A 129
VAL A 226
TRP A 227
 ADP  A1801 (-3.1A)
None
None
 0.88A 1qw6A-1u6rA:
undetectable		 1qw6A-1u6rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG A 129
VAL A 226
TRP A 227
 ADP  A1801 (-3.1A)
None
None
 0.88A 1qwcA-1u6rA:
undetectable		 1qwcA-1u6rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG A 129
VAL A 226
TRP A 227
 ADP  A1801 (-3.1A)
None
None
 0.88A 1vagA-1u6rA:
undetectable		 1vagA-1u6rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG A 129
VAL A 226
TRP A 227
 ADP  A1801 (-3.1A)
None
None
 0.86A 1zviA-1u6rA:
undetectable		 1zviA-1u6rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 7 ARG A 131
GLY A 289
ARG A 340
GLU A 231
 ADP  A1801 (-3.8A)
None
None
None
 1.06A 2c8aD-1u6rA:
undetectable		 2c8aD-1u6rA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 7 HIS A 105
ASN A 273
GLY A 287
TYR A 278
 None
 0.95A 2f6dA-1u6rA:
undetectable		 2f6dA-1u6rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ASN A 285
ARG A 340
ASP A 334
 None
None
ADP  A1801 (-3.3A)
 0.94A 2qe6A-1u6rA:
undetectable		 2qe6A-1u6rA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ASN A 285
ARG A 340
ASP A 334
 None
None
ADP  A1801 (-3.3A)
 0.95A 2qe6B-1u6rA:
undetectable		 2qe6B-1u6rA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG A 208
GLU A 154
SER A 204
 None
 0.74A 2xkkA-1u6rA:
undetectable
2xkkC-1u6rA:
undetectable		 2xkkA-1u6rA:
19.97
2xkkC-1u6rA:
19.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 6 THR A  70
VAL A  71
GLU A 231
CYH A 282
SER A 284
 None
 0.82A 3b6rB-1u6rA:
53.8		 3b6rB-1u6rA:
79.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 5 ILE A  92
HIS A  96
TYR A  81
GLY A 287
 None
 1.22A 3b9mA-1u6rA:
1.1		 3b9mA-1u6rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ASN A 229
MET A 178
PHE A 193
 None
 1.08A 3g4lD-1u6rA:
undetectable		 3g4lD-1u6rA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 7 ASN A  27
MET A  29
LEU A  87
LEU A  22
 None
 1.20A 3nk2X-1u6rA:
undetectable		 3nk2X-1u6rA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 9 PHE A 224
VAL A 226
PHE A 270
GLY A 133
PHE A 263
 None
 1.20A 3t3rB-1u6rA:
0.0		 3t3rB-1u6rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 9 PHE A 224
VAL A 226
PHE A 270
GLY A 133
PHE A 263
 None
 1.23A 3t3rC-1u6rA:
0.0		 3t3rC-1u6rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 10 PHE A 224
VAL A 226
PHE A 270
GLY A 133
PHE A 263
 None
 1.23A 3t3rD-1u6rA:
0.0		 3t3rD-1u6rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 PHE A 168
SER A 223
SER A 238
 None
 1.01A 3ufgB-1u6rA:
undetectable		 3ufgB-1u6rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 ARG A 250
PHE A 249
VAL A 254
PHE A 252
GLU A 247
 None
 1.42A 4bvaA-1u6rA:
undetectable		 4bvaA-1u6rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 ARG A 250
PHE A 249
VAL A 254
PHE A 252
GLU A 247
 None
 1.40A 4bvaB-1u6rA:
undetectable		 4bvaB-1u6rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ASP A  77
ARG A 208
THR A  46
 None
 0.84A 4i13A-1u6rA:
undetectable		 4i13A-1u6rA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 VAL A 324
GLY A 320
LYS A 318
 ADP  A1801 (-4.3A)
None
None
 0.75A 4k50A-1u6rA:
1.3		 4k50A-1u6rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 VAL A 324
GLY A 320
LYS A 318
 ADP  A1801 (-4.3A)
None
None
 0.76A 4k50E-1u6rA:
undetectable		 4k50E-1u6rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 VAL A 324
GLY A 320
LYS A 318
 ADP  A1801 (-4.3A)
None
None
 0.77A 4k50I-1u6rA:
undetectable		 4k50I-1u6rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ASP A  77
ARG A 208
THR A  46
 None
 0.84A 4p3rA-1u6rA:
undetectable		 4p3rA-1u6rA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 6 GLU A 274
GLY A 133
ASP A 232
GLY A 289
 None
 0.88A 5cdnA-1u6rA:
1.6
5cdnB-1u6rA:
undetectable		 5cdnA-1u6rA:
22.73
5cdnB-1u6rA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 6 GLU A 274
GLY A 133
ASP A 232
GLY A 289
 None
 0.90A 5cdnR-1u6rA:
undetectable
5cdnS-1u6rA:
undetectable		 5cdnR-1u6rA:
22.73
5cdnS-1u6rA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 6 GLU A 274
GLY A 133
ASP A 232
GLY A 289
 None
 0.91A 5cdnC-1u6rA:
undetectable
5cdnD-1u6rA:
undetectable		 5cdnC-1u6rA:
22.73
5cdnD-1u6rA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 6 GLU A 274
GLY A 133
ASP A 232
GLY A 289
 None
 0.90A 5cdnT-1u6rA:
undetectable
5cdnU-1u6rA:
undetectable		 5cdnT-1u6rA:
22.73
5cdnU-1u6rA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG A 129
VAL A 226
TRP A 227
 ADP  A1801 (-3.1A)
None
None
 0.88A 5fvoA-1u6rA:
undetectable		 5fvoA-1u6rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		4 / 6 ASP A 118
GLY A 116
ASP A 119
LYS A 246
 None
 1.31A 5hp1C-1u6rA:
4.3		 5hp1C-1u6rA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 VAL A 324
GLU A 230
GLU A 231
 ADP  A1801 (-4.3A)
None
None
 0.84A 5jsdB-1u6rA:
0.0
5jsdC-1u6rA:
undetectable		 5jsdB-1u6rA:
18.62
5jsdC-1u6rA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 GLU A 231
LEU A 141
GLY A 133
ASN A 285
LEU A 286
 None
 1.15A 5kc4E-1u6rA:
undetectable		 5kc4E-1u6rA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 LYS A 176
SER A 177
ASP A 212
ALA A 213
ARG A 151
 None
 1.30A 5zvgA-1u6rA:
undetectable		 5zvgA-1u6rA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1u6r CREATINE KINASE, M
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 LYS A 176
SER A 177
ASP A 212
ALA A 213
ARG A 151
 None
 1.29A 5zvgB-1u6rA:
undetectable		 5zvgB-1u6rA:
24.24