SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HVY_C_D16C416_1 (THYMIDYLATE SYNTHASE)	1u6t	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN (Homo sapiens)	5 / 11	PHE A 81 ILE A 68 LEU A 96 GLY A 95 PHE A 93	None	1.26A	1hvyC-1u6tA: undetectable	1hvyC-1u6tA: 17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_D_D16D609_1 (THYMIDYLATE SYNTHASE)	1u6t	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN (Homo sapiens)	5 / 9	PHE A 81 ILE A 68 LEU A 96 GLY A 95 PHE A 93	None	1.28A	2tsrD-1u6tA: undetectable	2tsrD-1u6tA: 16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L2V_A_RLTA397_1 (INTEGRASE)	1u6t	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN (Homo sapiens)	4 / 7	ASP A 79 ASP A 77 PRO A 66 GLN A 19	None	1.26A	3l2vA-1u6tA: undetectable	3l2vA-1u6tA: 12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MIH_A_CUA357_0 (PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE)	1u6t	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN (Homo sapiens)	3 / 3	HIS A 120 HIS A 117 HIS A 116	None	0.78A	3mihA-1u6tA: undetectable	3mihA-1u6tA: 16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EB4_C_D16C402_1 (THYMIDYLATE SYNTHASE)	1u6t	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN (Homo sapiens)	5 / 9	PHE A 81 ILE A 68 LEU A 96 GLY A 95 PHE A 93	None	1.33A	4eb4C-1u6tA: undetectable	4eb4C-1u6tA: 15.69

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HVY_C_D16C416_1","THYMIDYLATE SYNTHASE","1u6t","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN","Homo sapiens",5,"PHE A  81;ILE A  68;LEU A  96;GLY A  95;PHE A  93","None","1.26A","1hvyC-1u6tA:undetectable","1hvyC-1u6tA:17.61"],["2TSR_D_D16D609_1","THYMIDYLATE SYNTHASE","1u6t","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN","Homo sapiens",5,"PHE A  81;ILE A  68;LEU A  96;GLY A  95;PHE A  93","None","1.28A","2tsrD-1u6tA:undetectable","2tsrD-1u6tA:16.94"],["3L2V_A_RLTA397_1","INTEGRASE","1u6t","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN","Homo sapiens",4,"ASP A  79;ASP A  77;PRO A  66;GLN A  19","None","1.26A","3l2vA-1u6tA:undetectable","3l2vA-1u6tA:12.73"],["3MIH_A_CUA357_0","PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE","1u6t","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN","Homo sapiens",3,"HIS A 120;HIS A 117;HIS A 116","None","0.78A","3mihA-1u6tA:undetectable","3mihA-1u6tA:16.99"],["4EB4_C_D16C402_1","THYMIDYLATE SYNTHASE","1u6t","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN","Homo sapiens",5,"PHE A  81;ILE A  68;LEU A  96;GLY A  95;PHE A  93","None","1.33A","4eb4C-1u6tA:undetectable","4eb4C-1u6tA:15.69"]]