SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		3 / 3 SER A  58
GLU A  59
GLU A  60
 None
 0.67A 1eqbD-1u6zA:
undetectable		 1eqbD-1u6zA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		3 / 3 SER A 264
GLU A 265
GLU A 266
 SO4  A 703 (-2.7A)
None
None
 0.53A 1eqbD-1u6zA:
undetectable		 1eqbD-1u6zA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		3 / 3 SER A  58
GLU A  59
GLU A  60
 None
 0.67A 1eqbB-1u6zA:
undetectable		 1eqbB-1u6zA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		3 / 3 SER A 264
GLU A 265
GLU A 266
 SO4  A 703 (-2.7A)
None
None
 0.52A 1eqbB-1u6zA:
undetectable		 1eqbB-1u6zA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		3 / 3 ILE A 436
LEU A 439
VAL A 443
 None
 0.33A 1mz9B-1u6zA:
undetectable		 1mz9B-1u6zA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		3 / 3 SER A  20
GLY A  19
ARG A  93
 SO4  A 701 (-3.0A)
SO4  A 701 (-3.4A)
None
 0.66A 1t9wA-1u6zA:
3.0		 1t9wA-1u6zA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 8 LEU A 441
GLY A 442
LEU A 486
PRO A 455
 None
 0.74A 1ya4A-1u6zA:
undetectable		 1ya4A-1u6zA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 7 LEU A 441
GLY A 442
LEU A 486
PRO A 455
 None
 0.77A 1ya4B-1u6zA:
undetectable		 1ya4B-1u6zA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 11 GLY A 396
PRO A 395
ASN A 119
ARG A  93
VAL A 162
 None
 1.46A 2fl5A-1u6zA:
0.0
2fl5B-1u6zA:
0.0
2fl5F-1u6zA:
undetectable		 2fl5A-1u6zA:
17.56
2fl5B-1u6zA:
19.00
2fl5F-1u6zA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 12 ALA A  95
LEU A 102
LYS A 103
PHE A 101
LEU A  69
 None
 1.03A 2oipB-1u6zA:
undetectable		 2oipB-1u6zA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		6 / 12 ALA A  95
LEU A 102
LYS A 103
PHE A 101
ILE A  86
LEU A  69
 None
 1.39A 2oipE-1u6zA:
undetectable		 2oipE-1u6zA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 7 SER A 148
LEU A 124
ALA A 122
LEU A 297
 SO4  A 701 (-4.2A)
None
None
None
 1.04A 3cfqA-1u6zA:
undetectable
3cfqB-1u6zA:
undetectable		 3cfqA-1u6zA:
13.29
3cfqB-1u6zA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 11 LEU A 444
ILE A 503
LEU A 469
PHE A 471
THR A 452
 None
 1.24A 3fl9C-1u6zA:
undetectable		 3fl9C-1u6zA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 10 LEU A 444
ILE A 503
LEU A 469
PHE A 471
THR A 452
 None
 1.16A 3fl9E-1u6zA:
undetectable		 3fl9E-1u6zA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 12 ALA A  95
LEU A 102
LYS A 103
PHE A 101
LEU A  69
 None
 0.82A 3hj3B-1u6zA:
undetectable		 3hj3B-1u6zA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 9 ASP A 485
LEU A 445
THR A 339
HIS A 370
LEU A 441
 None
 1.09A 3hy7A-1u6zA:
undetectable		 3hy7A-1u6zA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 12 THR A  89
GLY A  19
GLY A 146
HIS A  90
GLU A 114
 SO4  A 701 (-4.3A)
SO4  A 701 (-3.4A)
SO4  A 701 (-3.4A)
None
None
 1.37A 3tkaA-1u6zA:
undetectable		 3tkaA-1u6zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 5 LEU A 441
GLY A 442
PHE A 471
ASN A 447
 None
None
None
SO4  A 705 ( 3.9A)
 1.32A 3uq6B-1u6zA:
undetectable		 3uq6B-1u6zA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 7 LEU A 124
ALA A 122
LEU A 297
SER A 148
 None
None
None
SO4  A 701 (-4.2A)
 1.03A 4ikjA-1u6zA:
undetectable
4ikjB-1u6zA:
undetectable		 4ikjA-1u6zA:
13.50
4ikjB-1u6zA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 7 SER A 148
LEU A 124
ALA A 122
LEU A 297
 SO4  A 701 (-4.2A)
None
None
None
 1.04A 4ikkA-1u6zA:
undetectable
4ikkB-1u6zA:
undetectable		 4ikkA-1u6zA:
13.50
4ikkB-1u6zA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 12 ALA A 190
GLY A 280
LEU A 285
ALA A 193
GLU A 163
 None
 1.12A 4lg1B-1u6zA:
undetectable		 4lg1B-1u6zA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 11 LEU A 285
ALA A 213
ILE A 236
ILE A 220
ILE A 287
 None
SO4  A 704 ( 4.5A)
None
None
SO4  A 704 (-4.1A)
 0.91A 4qgiB-1u6zA:
undetectable		 4qgiB-1u6zA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 10 ALA A  95
LEU A  51
SER A  20
LEU A  47
ALA A  48
 None
None
SO4  A 701 (-3.0A)
None
None
 1.21A 4zbrA-1u6zA:
undetectable		 4zbrA-1u6zA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 9 THR A 149
ILE A 144
GLY A 280
LEU A 285
LEU A 140
 None
 1.33A 4ze0A-1u6zA:
undetectable		 4ze0A-1u6zA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 8 LEU A 290
GLY A 215
ALA A 216
SER A 293
 None
 0.82A 5f1aA-1u6zA:
undetectable		 5f1aA-1u6zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 7 LEU A 290
GLY A 215
ALA A 216
SER A 293
 None
 0.80A 5f1aB-1u6zA:
undetectable		 5f1aB-1u6zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 8 GLU A 150
HIS A  90
GLY A 145
GLY A 146
 None
None
SO4  A 701 (-3.4A)
SO4  A 701 (-3.4A)
 0.75A 5f8yA-1u6zA:
undetectable		 5f8yA-1u6zA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 8 GLU A 150
HIS A  90
GLY A 145
GLY A 146
 None
None
SO4  A 701 (-3.4A)
SO4  A 701 (-3.4A)
 0.73A 5f8yB-1u6zA:
0.0		 5f8yB-1u6zA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		3 / 3 VAL A  16
LEU A  57
MET A  62
 None
 0.73A 5ikrA-1u6zA:
undetectable		 5ikrA-1u6zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 6 VAL A 270
LEU A  47
SER A  20
PHE A  23
 None
None
SO4  A 701 (-3.0A)
None
 0.97A 5jw1A-1u6zA:
undetectable		 5jw1A-1u6zA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		3 / 3 HIS A 384
SER A 385
ARG A 413
 None
None
SO4  A 707 ( 3.0A)
 1.01A 5u63A-1u6zA:
undetectable		 5u63A-1u6zA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 8 GLY A 274
LEU A 278
VAL A 281
ILE A 220
GLY A 218
 None
None
None
None
SO4  A 702 (-3.4A)
 1.13A 5vkqB-1u6zA:
undetectable
5vkqC-1u6zA:
undetectable		 5vkqB-1u6zA:
15.44
5vkqC-1u6zA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A  76
PHE A  13
VAL A  84
THR A 132
GLY A 295
 None
 1.22A 5xiqA-1u6zA:
undetectable		 5xiqA-1u6zA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A  76
PHE A  13
VAL A  84
THR A 132
GLY A 295
 None
 1.21A 5xiqD-1u6zA:
undetectable		 5xiqD-1u6zA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1u6z EXOPOLYPHOSPHATASE
(Escherichia
coli) 		4 / 7 PHE A 172
LEU A 175
ALA A 193
GLN A 196
 None
 1.07A 6b89A-1u6zA:
0.5		 6b89A-1u6zA:
10.39