SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
PHE A  34
THR A  56
LEU A  67
ARG A  70
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
 0.86A 1ao8A-1u70A:
19.5		 1ao8A-1u70A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
LEU A  67
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-4.4A)
 1.10A 1ao8A-1u70A:
19.5		 1ao8A-1u70A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.43A 1cd2A-1u70A:
25.2		 1cd2A-1u70A:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 8 GLY A 117
GLY A  15
PHE A 148
GLY A  17
 NDP  A 188 (-2.3A)
None
None
NDP  A 188 ( 3.9A)
 0.72A 1d0vA-1u70A:
undetectable		 1d0vA-1u70A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.49A 1d1gA-1u70A:
16.7		 1d1gA-1u70A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.58A 1d1gB-1u70A:
16.8		 1d1gB-1u70A:
25.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.59A 1ddrA-1u70A:
19.4		 1ddrA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.43A 1ddrB-1u70A:
19.8		 1ddrB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.50A 1ddsA-1u70A:
19.7		 1ddsA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.58A 1ddsB-1u70A:
20.0		 1ddsB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.49A 1df7A-1u70A:
20.6		 1df7A-1u70A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ILE A   7
ALA A   9
PHE A  34
SER A  59
PRO A  61
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 (-4.8A)
None
 0.70A 1dg5A-1u70A:
20.7		 1dg5A-1u70A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		12 / 12 ILE A   7
ALA A   9
PHE A  31
PHE A  34
GLN A  35
THR A  56
ILE A  60
PRO A  61
ASN A  64
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.7A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.58A 1dhfA-1u70A:
31.2		 1dhfA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		12 / 12 ILE A   7
ALA A   9
PHE A  31
PHE A  34
GLN A  35
THR A  56
ILE A  60
ASN A  64
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.7A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.35A 1dhfB-1u70A:
31.1		 1dhfB-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.66A 1dhiA-1u70A:
19.6		 1dhiA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 11 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.51A 1dhiB-1u70A:
20.1		 1dhiB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.67A 1dhjA-1u70A:
19.8		 1dhjA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.63A 1dhjB-1u70A:
20.1		 1dhjB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		12 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  31
GLN A  35
SER A  59
ILE A  60
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.7A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.50A 1dlsA-1u70A:
31.8		 1dlsA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.61A 1draA-1u70A:
19.8		 1draA-1u70A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.48A 1draB-1u70A:
20.2		 1draB-1u70A:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.67A 1drbA-1u70A:
19.8		 1drbA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.55A 1drbB-1u70A:
20.1		 1drbB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.72A 1dreA-1u70A:
20.4		 1dreA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
SER A  59
PRO A  61
LEU A  67
TYR A 121
 NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
 0.83A 1drfA-1u70A:
30.9		 1drfA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
PHE A  31
PHE A  34
GLN A  35
ILE A  60
PRO A  61
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.7A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
 0.47A 1drfA-1u70A:
30.9		 1drfA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 4 GLU A  30
ASN A  64
ARG A  70
THR A 136
 MTX  A 187 (-3.0A)
MTX  A 187 (-3.6A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.78A 1drfA-1u70A:
30.9		 1drfA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.47A 1dyiA-1u70A:
19.8		 1dyiA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.46A 1dyiB-1u70A:
20.0		 1dyiB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 11 ILE A   7
ALA A   9
GLU A  30
PHE A  34
ILE A  60
PRO A  61
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
None
MTX  A 187 (-4.4A)
 0.49A 1dyrA-1u70A:
24.9		 1dyrA-1u70A:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.47A 1j3jA-1u70A:
22.3		 1j3jA-1u70A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.64A 1j3jA-1u70A:
22.3		 1j3jA-1u70A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 9 ALA A   9
PHE A  34
ILE A  60
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.33A 1j3jB-1u70A:
22.1		 1j3jB-1u70A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 9 ALA A   9
PHE A  34
SER A  59
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.60A 1j3jB-1u70A:
22.1		 1j3jB-1u70A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 8 GLY A 117
GLY A  15
PHE A 148
GLY A  17
 NDP  A 188 (-2.3A)
None
None
NDP  A 188 ( 3.9A)
 0.72A 1jhaA-1u70A:
undetectable		 1jhaA-1u70A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 8 GLY A 117
GLY A  15
PHE A 148
GLY A  17
 NDP  A 188 (-2.3A)
None
None
NDP  A 188 ( 3.9A)
 0.73A 1jhqA-1u70A:
undetectable		 1jhqA-1u70A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 8 GLY A 117
GLY A  15
PHE A 148
GLY A  17
 NDP  A 188 (-2.3A)
None
None
NDP  A 188 ( 3.9A)
 0.74A 1jhvA-1u70A:
undetectable		 1jhvA-1u70A:
18.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.58A 1jolA-1u70A:
19.9		 1jolA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.62A 1jolB-1u70A:
20.0		 1jolB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 11 ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.54A 1jomA-1u70A:
19.4		 1jomA-1u70A:
33.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.52A 1qzfA-1u70A:
21.7		 1qzfA-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.54A 1qzfB-1u70A:
21.7		 1qzfB-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.53A 1qzfC-1u70A:
21.7		 1qzfC-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.54A 1qzfD-1u70A:
21.6		 1qzfD-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.54A 1qzfE-1u70A:
21.7		 1qzfE-1u70A:
17.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.52A 1ra2A-1u70A:
19.9		 1ra2A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.51A 1ra3A-1u70A:
19.9		 1ra3A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.48A 1ra8A-1u70A:
19.8		 1ra8A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.52A 1rb2A-1u70A:
20.0		 1rb2A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.28A 1rb2B-1u70A:
20.0		 1rb2B-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.49A 1rb3A-1u70A:
20.0		 1rb3A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.55A 1rb3B-1u70A:
20.0		 1rb3B-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ILE A   7
SER A  59
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.68A 1rb3B-1u70A:
20.0		 1rb3B-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.51A 1rd7A-1u70A:
19.4		 1rd7A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.51A 1rd7B-1u70A:
19.4		 1rd7B-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.42A 1re7A-1u70A:
19.6		 1re7A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.52A 1re7B-1u70A:
19.4		 1re7B-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
THR A  56
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.49A 1rg7A-1u70A:
18.5		 1rg7A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.69A 1rh3A-1u70A:
20.4		 1rh3A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.61A 1rx2A-1u70A:
20.4		 1rx2A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.66A 1rx3A-1u70A:
20.4		 1rx3A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.53A 1rx7A-1u70A:
19.4		 1rx7A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.58A 1rx8A-1u70A:
20.1		 1rx8A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.58A 1tdrA-1u70A:
19.8		 1tdrA-1u70A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.59A 1tdrB-1u70A:
20.0		 1tdrB-1u70A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		11 / 12 ALA A   9
GLU A  30
PHE A  31
GLN A  35
SER A  59
PRO A  61
ASN A  64
LEU A  67
ARG A  70
VAL A 115
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.7A)
NDP  A 188 ( 3.8A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
None
 0.54A 1u72A-1u70A:
31.6		 1u72A-1u70A:
89.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.48A 2bl9A-1u70A:
22.4		 2bl9A-1u70A:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.57A 2bl9A-1u70A:
22.4		 2bl9A-1u70A:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 11 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.71A 2blaA-1u70A:
22.4		 2blaA-1u70A:
29.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
PRO A  61
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.35A 2cd2A-1u70A:
25.3		 2cd2A-1u70A:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.43A 2d0kA-1u70A:
19.3		 2d0kA-1u70A:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.37A 2d0kB-1u70A:
19.6		 2d0kB-1u70A:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.59A 2drcA-1u70A:
19.7		 2drcA-1u70A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.48A 2drcB-1u70A:
20.0		 2drcB-1u70A:
32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.69A 2oipA-1u70A:
22.4		 2oipA-1u70A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
LYS A  32
PHE A  34
THR A  56
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
None
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
None
MTX  A 187 (-4.4A)
 0.76A 2oipB-1u70A:
20.7		 2oipB-1u70A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.50A 2oipB-1u70A:
20.7		 2oipB-1u70A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.54A 2oipC-1u70A:
22.1		 2oipC-1u70A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.82A 2oipD-1u70A:
22.7		 2oipD-1u70A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
LYS A  32
PHE A  34
THR A  56
ILE A  60
TYR A 121
 NDP  A 188 (-3.6A)
None
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
None
 0.94A 2oipE-1u70A:
21.6		 2oipE-1u70A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.75A 2oipE-1u70A:
21.6		 2oipE-1u70A:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.73A 2qk8A-1u70A:
20.9		 2qk8A-1u70A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		10 / 11 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
ILE A  60
PRO A  61
VAL A 115
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.0A)
None
MTX  A 187 (-4.4A)
 0.41A 2w3aA-1u70A:
30.9		 2w3aA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 11 ILE A   7
PHE A  31
PHE A  34
THR A  56
ILE A  60
PRO A  61
VAL A 115
TYR A 121
 MTX  A 187 (-3.8A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.0A)
None
 1.28A 2w3aA-1u70A:
30.9		 2w3aA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 10 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.48A 2w3aB-1u70A:
30.7		 2w3aB-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		10 / 12 ILE A   7
ALA A   9
PHE A  31
PHE A  34
THR A  56
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.35A 2w3bA-1u70A:
30.9		 2w3bA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		10 / 12 ILE A   7
ALA A   9
PHE A  31
PHE A  34
ILE A  60
PRO A  61
ASN A  64
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.32A 2w3bB-1u70A:
30.8		 2w3bB-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 GLU A  30
GLN A  35
ARG A  70
 MTX  A 187 (-3.0A)
MTX  A 187 (-3.7A)
MTX  A 187 (-3.1A)
 0.27A 2w3bB-1u70A:
30.8		 2w3bB-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		11 / 12 ILE A   7
ALA A   9
PHE A  31
PHE A  34
GLN A  35
ILE A  60
PRO A  61
ASN A  64
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.7A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.29A 2w3mA-1u70A:
31.2		 2w3mA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		11 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  31
PHE A  34
GLN A  35
ASN A  64
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.7A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.38A 2w3mB-1u70A:
31.2		 2w3mB-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
PHE A  34
SER A  59
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.71A 2w3vA-1u70A:
21.5		 2w3vA-1u70A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.77A 2w9sA-1u70A:
20.3		 2w9sA-1u70A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.74A 2w9sB-1u70A:
20.3		 2w9sB-1u70A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.74A 2w9sC-1u70A:
20.3		 2w9sC-1u70A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.65A 2w9sD-1u70A:
19.9		 2w9sD-1u70A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 8 ILE A   7
ALA A   9
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
None
MTX  A 187 (-4.4A)
 0.17A 2w9sE-1u70A:
19.9		 2w9sE-1u70A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.66A 2w9sF-1u70A:
19.8		 2w9sF-1u70A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.59A 2zzaA-1u70A:
20.8		 2zzaA-1u70A:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 11 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.58A 2zzaB-1u70A:
20.7		 2zzaB-1u70A:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 LEU A  93
TRP A 113
TYR A 121
 None
 0.88A 3aicA-1u70A:
undetectable		 3aicA-1u70A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 LEU A  93
TRP A 113
TYR A 121
 None
 0.93A 3aicB-1u70A:
undetectable		 3aicB-1u70A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 LEU A  93
TRP A 113
TYR A 121
 None
 0.95A 3aicE-1u70A:
undetectable		 3aicE-1u70A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 LEU A  93
TRP A 113
TYR A 121
 None
 0.95A 3aicF-1u70A:
undetectable		 3aicF-1u70A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 LEU A  93
TRP A 113
TYR A 121
 None
 0.91A 3aicG-1u70A:
undetectable		 3aicG-1u70A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 LEU A  93
TRP A 113
TYR A 121
 None
 0.95A 3aicH-1u70A:
undetectable		 3aicH-1u70A:
12.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
GLU A  30
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.37A 3cd2A-1u70A:
25.2		 3cd2A-1u70A:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
THR A  56
SER A  59
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.44A 3cl9A-1u70A:
22.1		 3cl9A-1u70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ALA A   9
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.55A 3clbA-1u70A:
22.3		 3clbA-1u70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
None
 0.36A 3clbB-1u70A:
21.6		 3clbB-1u70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
THR A  56
ILE A  60
PRO A  61
TYR A 121
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
None
 0.60A 3clbB-1u70A:
21.6		 3clbB-1u70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
THR A  56
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.53A 3clbC-1u70A:
22.0		 3clbC-1u70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ALA A   9
ILE A  60
PRO A  61
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
None
MTX  A 187 (-4.4A)
 0.42A 3clbD-1u70A:
22.0		 3clbD-1u70A:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.75A 3datA-1u70A:
21.0		 3datA-1u70A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.50A 3dauA-1u70A:
20.7		 3dauA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.60A 3drcA-1u70A:
19.8		 3drcA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.46A 3drcB-1u70A:
20.1		 3drcB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.38A 3eigA-1u70A:
30.3		 3eigA-1u70A:
88.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
SER A  59
PRO A  61
ASN A  64
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 ( 3.8A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
None
 0.67A 3eigA-1u70A:
30.3		 3eigA-1u70A:
88.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 5 ASP A  21
ILE A  60
VAL A 115
THR A 136
 None
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.83A 3eigA-1u70A:
30.3		 3eigA-1u70A:
88.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
GLU A  30
LEU A  67
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.72A 3fl9B-1u70A:
19.9		 3fl9B-1u70A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 GLU A  30
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 1.00A 3fl9B-1u70A:
19.9		 3fl9B-1u70A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
GLU A  30
LEU A  67
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.75A 3fl9G-1u70A:
19.7		 3fl9G-1u70A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 GLU A  30
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 1.03A 3fl9G-1u70A:
19.7		 3fl9G-1u70A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 11 ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.81A 3frbX-1u70A:
20.1		 3frbX-1u70A:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 MET A 111
MET A  52
PHE A 134
 None
 1.31A 3gn8A-1u70A:
undetectable		 3gn8A-1u70A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ALA A   9
ILE A  60
PRO A  61
LEU A  67
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
 0.55A 3hbbA-1u70A:
22.3		 3hbbA-1u70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ALA A   9
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.54A 3hbbC-1u70A:
22.0		 3hbbC-1u70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ALA A   9
ILE A  60
PRO A  61
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
None
MTX  A 187 (-4.4A)
 0.36A 3hbbD-1u70A:
22.1		 3hbbD-1u70A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.76A 3hj3A-1u70A:
23.1		 3hj3A-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
LYS A  32
PHE A  34
THR A  56
ILE A  60
TYR A 121
 NDP  A 188 (-3.6A)
None
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
None
 1.10A 3hj3B-1u70A:
23.1		 3hj3B-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.69A 3hj3B-1u70A:
23.1		 3hj3B-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.63A 3hj3C-1u70A:
6.5		 3hj3C-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.76A 3hj3D-1u70A:
6.9		 3hj3D-1u70A:
17.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
GLU A  30
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.82A 3ia4A-1u70A:
20.7		 3ia4A-1u70A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.76A 3ia4B-1u70A:
20.7		 3ia4B-1u70A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ALA A   9
GLU A  30
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.76A 3ia4C-1u70A:
20.8		 3ia4C-1u70A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.73A 3ia4D-1u70A:
20.7		 3ia4D-1u70A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
GLU A  30
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.53A 3ix9A-1u70A:
21.2		 3ix9A-1u70A:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
GLU A  30
LEU A  67
ARG A  70
VAL A 115
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.52A 3ix9B-1u70A:
20.6		 3ix9B-1u70A:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
LEU A  67
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-4.4A)
 1.08A 3jw3A-1u70A:
20.8		 3jw3A-1u70A:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.68A 3jw3A-1u70A:
20.8		 3jw3A-1u70A:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 9 ALA A   9
GLU A  30
ILE A  60
LEU A  67
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 1.05A 3jw3B-1u70A:
20.9		 3jw3B-1u70A:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
LEU A  67
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-4.4A)
 0.74A 3jw5B-1u70A:
20.8		 3jw5B-1u70A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  31
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.68A 3k2hA-1u70A:
23.9		 3k2hA-1u70A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  31
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.64A 3k2hB-1u70A:
23.0		 3k2hB-1u70A:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		11 / 11 ILE A   7
ALA A   9
GLU A  30
PHE A  31
PHE A  34
THR A  56
ILE A  60
LEU A  67
VAL A 115
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 ( 4.0A)
None
MTX  A 187 (-4.4A)
 0.51A 3n0hA-1u70A:
31.1		 3n0hA-1u70A:
88.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  31
THR A  56
ILE A  60
PRO A  61
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 (-4.4A)
 0.40A 3nrrA-1u70A:
23.3		 3nrrA-1u70A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  31
THR A  56
ILE A  60
PRO A  61
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 (-4.4A)
 0.55A 3nrrB-1u70A:
24.1		 3nrrB-1u70A:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.66A 3qfxA-1u70A:
22.0		 3qfxA-1u70A:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.65A 3qfxB-1u70A:
22.0		 3qfxB-1u70A:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.39A 3qg2A-1u70A:
22.4		 3qg2A-1u70A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.60A 3qg2A-1u70A:
22.4		 3qg2A-1u70A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ILE A   7
ALA A   9
PHE A  34
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.34A 3qg2B-1u70A:
22.2		 3qg2B-1u70A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ILE A   7
ALA A   9
PHE A  34
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.55A 3qg2B-1u70A:
22.2		 3qg2B-1u70A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.46A 3qgtA-1u70A:
22.5		 3qgtA-1u70A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.61A 3qgtA-1u70A:
22.5		 3qgtA-1u70A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.38A 3qgtB-1u70A:
22.1		 3qgtB-1u70A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.55A 3qgtB-1u70A:
22.1		 3qgtB-1u70A:
15.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.54A 3ql0A-1u70A:
20.7		 3ql0A-1u70A:
34.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.57A 3ql3A-1u70A:
20.4		 3ql3A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		11 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  31
PHE A  34
THR A  56
ILE A  60
LEU A  67
VAL A 115
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 ( 4.0A)
None
MTX  A 187 (-4.4A)
 0.53A 3s3vA-1u70A:
31.1		 3s3vA-1u70A:
88.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 9 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.4A)
 0.75A 3tq8A-1u70A:
21.0		 3tq8A-1u70A:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.77A 3tq9A-1u70A:
21.0		 3tq9A-1u70A:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.47A 3tqbA-1u70A:
21.0		 3tqbA-1u70A:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.47A 3um5A-1u70A:
22.4		 3um5A-1u70A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
PHE A  34
THR A  56
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.62A 3um5A-1u70A:
22.4		 3um5A-1u70A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.48A 3um5B-1u70A:
22.3		 3um5B-1u70A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
PHE A  34
THR A  56
SER A  59
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.59A 3um5B-1u70A:
22.3		 3um5B-1u70A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 MET A  52
GLY A 117
SER A 118
VAL A  50
LEU A  67
 None
NDP  A 188 (-2.3A)
NDP  A 188 (-3.0A)
None
MTX  A 187 ( 4.5A)
 1.11A 3v8vA-1u70A:
undetectable		 3v8vA-1u70A:
13.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.34A 4cd2A-1u70A:
24.3		 4cd2A-1u70A:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.60A 4dfrA-1u70A:
19.7		 4dfrA-1u70A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.50A 4dfrB-1u70A:
19.9		 4dfrB-1u70A:
32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  31
PHE A  34
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.54A 4eckA-1u70A:
21.7		 4eckA-1u70A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  34
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.63A 4eckB-1u70A:
21.6		 4eckB-1u70A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ALA A   9
PHE A  31
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.36A 4eilA-1u70A:
23.7		 4eilA-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ALA A   9
PHE A  31
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.36A 4eilB-1u70A:
23.3		 4eilB-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ALA A   9
PHE A  31
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.36A 4eilC-1u70A:
23.9		 4eilC-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ALA A   9
PHE A  31
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.30A 4eilD-1u70A:
22.6		 4eilD-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ALA A   9
PHE A  31
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.33A 4eilE-1u70A:
24.5		 4eilE-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 9 ALA A   9
PHE A  31
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.36A 4eilF-1u70A:
22.6		 4eilF-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ALA A   9
PHE A  31
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.33A 4eilG-1u70A:
23.9		 4eilG-1u70A:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 0.49A 4ej1A-1u70A:
19.5		 4ej1A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.39A 4ej1B-1u70A:
19.5		 4ej1B-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.53A 4fhbA-1u70A:
19.9		 4fhbA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 10 ILE A   7
ALA A   9
GLU A  30
PHE A  34
SER A  59
PRO A  61
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-3.0A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 (-4.8A)
None
MTX  A 187 (-4.4A)
 0.70A 4g8zX-1u70A:
24.9		 4g8zX-1u70A:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.68A 4gh8A-1u70A:
21.6		 4gh8A-1u70A:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
PRO A  61
ASN A  64
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 (-3.6A)
MTX  A 187 (-3.1A)
None
 0.80A 4gh8B-1u70A:
21.3		 4gh8B-1u70A:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 0.46A 4i13A-1u70A:
19.4		 4i13A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 11 ILE A   7
ALA A   9
PHE A  34
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.41A 4i1nA-1u70A:
19.2		 4i1nA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		11 / 12 ILE A   7
ALA A   9
PHE A  31
PHE A  34
GLN A  35
THR A  56
ILE A  60
ASN A  64
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
MTX  A 187 (-3.7A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-3.6A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.30A 4kebB-1u70A:
31.3		 4kebB-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		10 / 12 ILE A   7
ALA A   9
PHE A  31
PHE A  34
ILE A  60
PRO A  61
LEU A  67
VAL A 115
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
MTX  A 187 ( 4.0A)
None
MTX  A 187 (-4.4A)
 0.32A 4kfjB-1u70A:
31.3		 4kfjB-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 4 GLU A  30
GLN A  35
ASN A  64
ARG A  70
 MTX  A 187 (-3.0A)
MTX  A 187 (-3.7A)
MTX  A 187 (-3.6A)
MTX  A 187 (-3.1A)
 0.26A 4kfjB-1u70A:
31.3		 4kfjB-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 0.59A 4kjjA-1u70A:
19.4		 4kjjA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 0.55A 4kjkA-1u70A:
20.2		 4kjkA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
ARG A  65
LEU A  67
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
None
MTX  A 187 ( 4.5A)
MTX  A 187 (-4.4A)
 1.24A 4kjlA-1u70A:
20.5		 4kjlA-1u70A:
34.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.57A 4kjlA-1u70A:
20.5		 4kjlA-1u70A:
34.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
THR A  56
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
None
MTX  A 187 (-4.4A)
 0.56A 4km0A-1u70A:
19.8		 4km0A-1u70A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
None
MTX  A 187 (-4.4A)
 0.52A 4km0B-1u70A:
20.1		 4km0B-1u70A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.54A 4km2A-1u70A:
20.1		 4km2A-1u70A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.44A 4km2B-1u70A:
19.7		 4km2B-1u70A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ILE A   7
PHE A  34
THR A  56
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
None
 0.59A 4km2B-1u70A:
19.7		 4km2B-1u70A:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.88A 4ky8A-1u70A:
15.8		 4ky8A-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.93A 4ky8B-1u70A:
16.9		 4ky8B-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
LYS A  32
SER A  59
ILE A  60
THR A 136
 NDP  A 188 (-3.6A)
None
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.4A)
 1.03A 4ky8C-1u70A:
23.2		 4ky8C-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.68A 4ky8C-1u70A:
23.2		 4ky8C-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.96A 4ky8D-1u70A:
19.6		 4ky8D-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 (-4.4A)
 0.94A 4ky8E-1u70A:
23.3		 4ky8E-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ALA A   9
THR A  56
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.29A 4kyaA-1u70A:
24.0		 4kyaA-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  31
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.37A 4kyaB-1u70A:
23.2		 4kyaB-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 10 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.32A 4kyaC-1u70A:
17.8		 4kyaC-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  31
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.41A 4kyaD-1u70A:
15.5		 4kyaD-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ALA A   9
THR A  56
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.32A 4kyaE-1u70A:
23.9		 4kyaE-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  31
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.40A 4kyaF-1u70A:
15.5		 4kyaF-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ALA A   9
THR A  56
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.31A 4kyaG-1u70A:
23.9		 4kyaG-1u70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  31
LEU A  67
ARG A  70
VAL A 115
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
MTX  A 187 ( 4.0A)
MTX  A 187 (-4.4A)
 0.39A 4kyaH-1u70A:
22.5		 4kyaH-1u70A:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
ASP A  21
PHE A  34
PRO A  61
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
None
MTX  A 187 (-4.3A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
 0.77A 4m2xA-1u70A:
20.2		 4m2xA-1u70A:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.52A 4m2xC-1u70A:
20.3		 4m2xC-1u70A:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
ALA A   9
ASP A  21
PRO A  61
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
None
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
 0.74A 4m2xE-1u70A:
20.1		 4m2xE-1u70A:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ILE A   7
ALA A   9
PRO A  61
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.8A)
None
MTX  A 187 (-4.4A)
 0.52A 4m2xG-1u70A:
20.0		 4m2xG-1u70A:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		10 / 12 ILE A   7
ALA A   9
PHE A  31
PHE A  34
THR A  56
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-4.8A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.33A 4m6kA-1u70A:
31.4		 4m6kA-1u70A:
89.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 4 GLU A  30
GLN A  35
ASN A  64
ARG A  70
 MTX  A 187 (-3.0A)
MTX  A 187 (-3.7A)
MTX  A 187 (-3.6A)
MTX  A 187 (-3.1A)
 0.30A 4m6kA-1u70A:
31.4		 4m6kA-1u70A:
89.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 8 LEU A 153
TYR A 156
TYR A 182
VAL A  10
 None
 0.90A 4ma7A-1u70A:
undetectable		 4ma7A-1u70A:
17.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 0.62A 4nx6A-1u70A:
20.4		 4nx6A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 0.67A 4nx7A-1u70A:
20.2		 4nx7A-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 0.55A 4p3qA-1u70A:
20.5		 4p3qA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 0.62A 4p3rA-1u70A:
20.3		 4p3rA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ILE A   7
ALA A   9
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.31A 4p66A-1u70A:
20.4		 4p66A-1u70A:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ILE A   7
PHE A  34
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.49A 4p68A-1u70A:
20.4		 4p68A-1u70A:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ILE A   7
PHE A  34
SER A  59
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
MTX  A 187 (-4.3A)
NDP  A 188 ( 3.8A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.58A 4p68A-1u70A:
20.4		 4p68A-1u70A:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
 0.62A 4pssA-1u70A:
undetectable		 4pssA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.66A 4pstA-1u70A:
undetectable		 4pstA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.64A 4psyA-1u70A:
20.2		 4psyA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.56A 4pthA-1u70A:
20.0		 4pthA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.54A 4ptjA-1u70A:
20.3		 4ptjA-1u70A:
33.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.65A 4q0dA-1u70A:
23.0		 4q0dA-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
LYS A  32
ILE A  60
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
None
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.86A 4q0dA-1u70A:
23.0		 4q0dA-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.66A 4q0dB-1u70A:
23.0		 4q0dB-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
LYS A  32
ILE A  60
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
None
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.86A 4q0dB-1u70A:
23.0		 4q0dB-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
LYS A  32
SER A  59
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
None
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.82A 4q0dC-1u70A:
22.9		 4q0dC-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
SER A  59
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.49A 4q0dC-1u70A:
22.9		 4q0dC-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
LYS A  32
SER A  59
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
None
NDP  A 188 ( 3.8A)
None
MTX  A 187 (-4.4A)
 0.82A 4q0dD-1u70A:
22.9		 4q0dD-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
SER A  59
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.49A 4q0dD-1u70A:
22.9		 4q0dD-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.65A 4q0dE-1u70A:
23.0		 4q0dE-1u70A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 12 ALA A   9
LYS A  32
ILE A  60
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
None
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.87A 4q0dE-1u70A:
23.0		 4q0dE-1u70A:
17.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.49A 4qi9A-1u70A:
18.4		 4qi9A-1u70A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.49A 4qi9B-1u70A:
18.8		 4qi9B-1u70A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 11 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.50A 4qi9C-1u70A:
17.9		 4qi9C-1u70A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.53A 4qleA-1u70A:
20.0		 4qleA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 11 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.55A 4qleB-1u70A:
20.0		 4qleB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 11 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.52A 4qlfA-1u70A:
17.4		 4qlfA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.52A 4qlgA-1u70A:
20.1		 4qlgA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.48A 4qlgB-1u70A:
19.8		 4qlgB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.57A 4rgcA-1u70A:
20.4		 4rgcA-1u70A:
33.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 8 ARG A  22
LEU A 133
ILE A   7
PHE A 148
 MTX  A 187 (-3.3A)
None
MTX  A 187 (-3.8A)
None
 0.84A 4v04A-1u70A:
undetectable		 4v04A-1u70A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 6 SER A  92
LEU A  93
ASP A  94
LEU A  75
 None
None
None
NDP  A 188 (-4.2A)
 0.93A 4wozA-1u70A:
undetectable
4wozB-1u70A:
undetectable		 4wozA-1u70A:
21.47
4wozB-1u70A:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.47A 4x5fA-1u70A:
19.8		 4x5fA-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.47A 4x5fB-1u70A:
20.1		 4x5fB-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.52A 4x5gA-1u70A:
19.7		 4x5gA-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.50A 4x5gB-1u70A:
20.1		 4x5gB-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.52A 4x5hA-1u70A:
19.5		 4x5hA-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.54A 4x5iA-1u70A:
19.3		 4x5iA-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.50A 4x5jA-1u70A:
19.4		 4x5jA-1u70A:
32.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		5 / 11 LEU A  49
LEU A  97
GLY A 129
HIS A 130
LEU A 131
 None
 1.18A 5dxgB-1u70A:
undetectable		 5dxgB-1u70A:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
None
MTX  A 187 (-4.4A)
 0.52A 5e8qA-1u70A:
19.7		 5e8qA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.52A 5e8qB-1u70A:
19.8		 5e8qB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.52A 5eajA-1u70A:
19.8		 5eajA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.54A 5eajB-1u70A:
19.9		 5eajB-1u70A:
33.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 MET A 139
GLN A  12
ARG A 137
 None
 1.05A 5ewzB-1u70A:
undetectable		 5ewzB-1u70A:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.48A 5hi6A-1u70A:
20.3		 5hi6A-1u70A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.61A 5hi6B-1u70A:
20.0		 5hi6B-1u70A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 12 ILE A   7
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 MTX  A 187 (-3.8A)
NDP  A 188 ( 3.8A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
 0.74A 5hi6B-1u70A:
20.0		 5hi6B-1u70A:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 MET A 139
GLN A  12
ARG A 137
 None
 1.06A 5m35B-1u70A:
undetectable		 5m35B-1u70A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 MET A 139
GLN A  12
ARG A 137
 None
 1.13A 5m36A-1u70A:
undetectable		 5m36A-1u70A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		4 / 8 ILE A   7
ALA A   9
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
None
MTX  A 187 (-4.4A)
 0.16A 5uihA-1u70A:
18.8		 5uihA-1u70A:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.55A 5ujxA-1u70A:
19.7		 5ujxA-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.55A 5ujxB-1u70A:
19.8		 5ujxB-1u70A:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
ARG A  70
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 (-3.1A)
None
MTX  A 187 (-4.4A)
 0.57A 5z6fA-1u70A:
20.4		 5z6fA-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.58A 5z6jA-1u70A:
20.4		 5z6jA-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
MTX  A 187 (-4.4A)
 0.58A 5z6kA-1u70A:
20.3		 5z6kA-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.40A 5z6kA-1u70A:
20.3		 5z6kA-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 11 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.48A 5z6mA-1u70A:
19.8		 5z6mA-1u70A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ALA A   9
PHE A  34
THR A  56
VAL A 115
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.0A)
None
MTX  A 187 (-4.4A)
 0.36A 6aogA-1u70A:
23.9		 6aogA-1u70A:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		6 / 10 ALA A   9
PHE A  34
THR A  56
VAL A 115
TYR A 121
THR A 136
 NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.0A)
None
MTX  A 187 (-4.4A)
 0.44A 6aogB-1u70A:
23.7		 6aogB-1u70A:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 MET A 139
GLN A  12
ARG A 137
 None
 1.08A 6fn9A-1u70A:
undetectable		 6fn9A-1u70A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 MET A 139
GLN A  12
ARG A 137
 None
 1.06A 6fnaB-1u70A:
undetectable		 6fnaB-1u70A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		3 / 3 MET A 139
GLN A  12
ARG A 137
 None
 1.10A 6fnbA-1u70A:
undetectable		 6fnbA-1u70A:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u70 DIHYDROFOLATE
REDUCTASE
(Mus
musculus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 MTX  A 187 (-3.8A)
NDP  A 188 (-3.6A)
MTX  A 187 (-4.3A)
NDP  A 188 (-3.9A)
MTX  A 187 ( 4.2A)
MTX  A 187 ( 4.5A)
None
MTX  A 187 (-4.4A)
 0.60A 7dfrA-1u70A:
20.5		 7dfrA-1u70A:
33.51