SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u7h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		4 / 4 LEU A 118
THR A 116
ILE A 197
HIS A 221
 None
 1.32A 2jfaB-1u7hA:
undetectable		 2jfaB-1u7hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		3 / 3 MET A  58
GLU A 248
ASN A 223
 None
 0.89A 3a27A-1u7hA:
6.0		 3a27A-1u7hA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		4 / 7 LEU A 235
GLU A 258
ASP A 292
THR A 202
 None
None
None
NAD  A 802 (-4.1A)
 1.14A 3dzgB-1u7hA:
undetectable		 3dzgB-1u7hA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		5 / 12 GLY A  89
ASP A   6
ILE A   5
ASP A 300
ARG A 112
 None
None
None
None
NAD  A 802 (-3.5A)
 1.14A 3iv6D-1u7hA:
6.0		 3iv6D-1u7hA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		5 / 11 LEU A 152
PHE A 148
ALA A 114
ALA A  27
ALA A 120
 None
 1.04A 3mdtB-1u7hA:
undetectable		 3mdtB-1u7hA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		4 / 6 ARG A 305
ASP A  62
ASP A  33
ARG A  36
 None
 0.93A 4kcnB-1u7hA:
undetectable		 4kcnB-1u7hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		3 / 3 ARG A 273
ASP A 270
TRP A 272
 None
 1.16A 4xdqA-1u7hA:
undetectable		 4xdqA-1u7hA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		4 / 8 LEU A 105
LEU A  91
TYR A 306
MET A  10
 None
 1.10A 5hbsA-1u7hA:
0.8		 5hbsA-1u7hA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		5 / 10 GLY A 136
GLY A 138
ASP A 163
THR A 202
ILE A 210
 NAD  A 802 ( 3.8A)
NAD  A 802 (-3.3A)
None
NAD  A 802 (-4.1A)
None
 0.33A 6exiA-1u7hA:
6.5		 6exiA-1u7hA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		5 / 10 GLY A 136
GLY A 138
ASP A 163
THR A 202
ILE A 210
 NAD  A 802 ( 3.8A)
NAD  A 802 (-3.3A)
None
NAD  A 802 (-4.1A)
None
 0.29A 6exiB-1u7hA:
11.1		 6exiB-1u7hA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		5 / 12 GLY A 136
GLY A 138
ASP A 163
THR A 202
ILE A 210
 NAD  A 802 ( 3.8A)
NAD  A 802 (-3.3A)
None
NAD  A 802 (-4.1A)
None
 0.32A 6exiC-1u7hA:
6.9
6exiD-1u7hA:
11.7		 6exiC-1u7hA:
13.16
6exiD-1u7hA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1u7h ORNITHINE
CYCLODEAMINASE
(Pseudomonas
putida) 		5 / 12 GLY A 136
GLY A 138
ASP A 163
THR A 202
ILE A 210
 NAD  A 802 ( 3.8A)
NAD  A 802 (-3.3A)
None
NAD  A 802 (-4.1A)
None
 0.31A 6exiC-1u7hA:
6.9
6exiD-1u7hA:
11.7		 6exiC-1u7hA:
13.16
6exiD-1u7hA:
13.16