SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		4 / 8 THR A 190
GLY A 186
GLY A 207
LEU A 176
 None
 0.77A 1d0vA-1u7nA:
undetectable		 1d0vA-1u7nA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 10 GLY A 283
HIS A 297
THR A 308
ILE A 294
THR A 300
 None
EOH  A 403 ( 4.1A)
None
None
None
 1.47A 1gtfP-1u7nA:
undetectable
1gtfQ-1u7nA:
undetectable		 1gtfP-1u7nA:
14.15
1gtfQ-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 8 GLY A 283
HIS A 297
THR A 308
ILE A 294
THR A 300
 None
EOH  A 403 ( 4.1A)
None
None
None
 1.45A 1gtnP-1u7nA:
undetectable
1gtnQ-1u7nA:
undetectable		 1gtnP-1u7nA:
14.15
1gtnQ-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		4 / 8 THR A 190
GLY A 186
GLY A 207
LEU A 176
 None
 0.72A 1jhvA-1u7nA:
2.0		 1jhvA-1u7nA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		4 / 6 ILE A 110
VAL A 111
ILE A 309
ASP A  92
 None
 0.77A 1uwhA-1u7nA:
undetectable		 1uwhA-1u7nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		4 / 6 ILE A 110
VAL A 111
ILE A 309
ASP A  92
 None
 0.78A 1uwhB-1u7nA:
undetectable		 1uwhB-1u7nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 10 VAL A  21
GLY A  20
THR A 308
VAL A   5
HIS A 297
 None
None
None
None
EOH  A 403 ( 4.1A)
 1.15A 1v3qE-1u7nA:
undetectable		 1v3qE-1u7nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 ASN A  99
ILE A  61
ASP A  64
GLU A  66
ALA A  70
 None
 1.10A 2dtjA-1u7nA:
undetectable
2dtjB-1u7nA:
undetectable		 2dtjA-1u7nA:
19.64
2dtjB-1u7nA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 12 ALA A 219
ASN A 216
ARG A 167
VAL A 232
ILE A 236
 None
 1.01A 3e00A-1u7nA:
undetectable		 3e00A-1u7nA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 12 ILE A   3
ALA A  91
ALA A 291
VAL A  21
ILE A  17
 None
 1.19A 3uvvB-1u7nA:
undetectable		 3uvvB-1u7nA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 12 MET A 315
VAL A 166
ARG A 167
ILE A 294
SER A 124
 None
 1.45A 4m11D-1u7nA:
undetectable		 4m11D-1u7nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 11 ASP A 140
ALA A 143
ASP A 137
GLY A 288
GLY A 159
 None
 1.02A 4xp4A-1u7nA:
0.0		 4xp4A-1u7nA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		4 / 5 GLN A  34
ILE A  55
ILE A  54
TYR A  36
 None
 1.11A 5dnuA-1u7nA:
undetectable		 5dnuA-1u7nA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.48A 5eeuB-1u7nA:
undetectable
5eeuC-1u7nA:
undetectable		 5eeuB-1u7nA:
14.15
5eeuC-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.48A 5eevB-1u7nA:
undetectable
5eevC-1u7nA:
undetectable		 5eevB-1u7nA:
14.15
5eevC-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.48A 5eexB-1u7nA:
undetectable
5eexC-1u7nA:
undetectable		 5eexB-1u7nA:
14.15
5eexC-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.48A 5eeyB-1u7nA:
undetectable
5eeyC-1u7nA:
0.0		 5eeyB-1u7nA:
14.15
5eeyC-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.47A 5ef0B-1u7nA:
undetectable
5ef0C-1u7nA:
0.0		 5ef0B-1u7nA:
14.15
5ef0C-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.47A 5ef2B-1u7nA:
undetectable
5ef2C-1u7nA:
undetectable		 5ef2B-1u7nA:
14.15
5ef2C-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.47A 5ef3B-1u7nA:
undetectable
5ef3C-1u7nA:
undetectable		 5ef3B-1u7nA:
14.15
5ef3C-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 10 ALA A  83
VAL A  86
ILE A 312
ILE A 294
ALA A 106
 None
 1.07A 5nukA-1u7nA:
undetectable		 5nukA-1u7nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 12 LEU A 108
SER A  96
LYS A 295
ILE A  61
ASP A  65
 None
 1.39A 6bxnA-1u7nA:
2.4		 6bxnA-1u7nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 12 LEU A 108
SER A  96
LYS A 295
ILE A  61
ASP A  65
 None
 1.38A 6bxnB-1u7nA:
3.3		 6bxnB-1u7nA:
22.29