SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4
(Homo
sapiens) 		3 / 3 ASP B 512
THR B 521
PRO B 522
 None
 0.69A 2pynB-1u7vB:
undetectable		 2pynB-1u7vB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4
(Homo
sapiens) 		3 / 3 ASP B 512
THR B 521
PRO B 522
 None
 0.68A 2qakB-1u7vB:
undetectable		 2qakB-1u7vB:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4
(Homo
sapiens) 		3 / 3 LYS B 314
ARG B 531
LYS B 436
 None
 1.37A 3okxA-1u7vB:
0.0		 3okxA-1u7vB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4
(Homo
sapiens) 		5 / 12 HIS B 317
LEU B 501
ASP B 396
LEU B 440
GLY B 395
 None
 1.16A 4foxB-1u7vB:
undetectable		 4foxB-1u7vB:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4
(Homo
sapiens) 		4 / 6 LEU B 498
GLN B 410
LEU B 501
GLU B 526
 None
 1.10A 4nc3A-1u7vB:
undetectable		 4nc3A-1u7vB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4
(Homo
sapiens) 		3 / 3 ARG B 372
TYR B 328
GLU B 330
 None
 0.67A 4zzbE-1u7vB:
undetectable		 4zzbE-1u7vB:
21.13