SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 7 MET A 257
SER A 212
ALA A 195
PHE A 218
 None
 1.12A 1fxvA-1u7wA:
undetectable
1fxvB-1u7wA:
undetectable		 1fxvA-1u7wA:
22.04
1fxvB-1u7wA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		6 / 12 GLY A 228
ALA A 229
ILE A 270
VAL A 397
ILE A 193
ILE A 191
 None
 1.28A 1hshA-1u7wA:
undetectable		 1hshA-1u7wA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 7 ASP A 309
VAL A 314
GLY A 326
ILE A 350
 CTP  A 500 (-4.1A)
None
CTP  A 500 (-3.6A)
None
 0.77A 1t7iB-1u7wA:
undetectable		 1t7iB-1u7wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 7 ASP A 309
VAL A 314
GLY A 326
ILE A 350
 CTP  A 500 (-4.1A)
None
CTP  A 500 (-3.6A)
None
 0.79A 1t7jB-1u7wA:
undetectable		 1t7jB-1u7wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		5 / 11 ARG A 248
ILE A 272
GLY A 389
ALA A 195
ILE A 193
 None
 0.98A 2b60B-1u7wA:
undetectable		 2b60B-1u7wA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		3 / 3 LYS A 385
GLY A 196
PRO A 197
 None
 0.75A 2hreB-1u7wA:
undetectable		 2hreB-1u7wA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		6 / 12 ALA A 328
GLY A 326
MET A 216
GLY A 389
LEU A 392
LEU A 391
 CTP  A 500 ( 4.0A)
CTP  A 500 (-3.6A)
None
None
None
None
 1.33A 2hw2A-1u7wA:
undetectable		 2hw2A-1u7wA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		5 / 8 ARG A 248
LEU A 233
ALA A 224
ILE A 272
GLY A 389
 None
 1.28A 2o4nB-1u7wA:
undetectable		 2o4nB-1u7wA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		5 / 12 ILE A 272
ALA A 195
PHE A 327
LEU A 369
THR A 194
 None
 1.32A 2w3mB-1u7wA:
undetectable		 2w3mB-1u7wA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 8 ILE A 272
VAL A 324
TYR A 400
TYR A 323
 None
 1.28A 2xz5A-1u7wA:
undetectable
2xz5C-1u7wA:
undetectable		 2xz5A-1u7wA:
20.42
2xz5C-1u7wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 7 ILE A 272
VAL A 324
TYR A 400
TYR A 323
 None
 1.29A 2xz5D-1u7wA:
undetectable
2xz5E-1u7wA:
undetectable		 2xz5D-1u7wA:
20.42
2xz5E-1u7wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 8 ASP A 309
VAL A 314
GLY A 326
ILE A 350
 CTP  A 500 (-4.1A)
None
CTP  A 500 (-3.6A)
None
 0.75A 3nu9A-1u7wA:
undetectable		 3nu9A-1u7wA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		5 / 11 ILE A 272
ALA A 195
PHE A 327
LEU A 369
THR A 194
 None
 1.29A 4i1nA-1u7wA:
undetectable		 4i1nA-1u7wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		4 / 5 ALA A 338
ALA A 328
ILE A 350
LEU A 347
 None
CTP  A 500 ( 4.0A)
None
None
 0.78A 5jncD-1u7wA:
undetectable		 5jncD-1u7wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		5 / 12 ILE A 270
ALA A 229
GLY A 228
ALA A 224
ILE A 191
 None
 0.87A 5kb6A-1u7wA:
3.7		 5kb6A-1u7wA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		5 / 12 ILE A 270
ALA A 229
GLY A 228
ALA A 224
ILE A 191
 None
 0.90A 5kb6B-1u7wA:
3.4		 5kb6B-1u7wA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		6 / 12 CYH A 274
ALA A 276
PRO A 197
GLY A 236
GLY A 326
LEU A 392
 None
None
None
None
CTP  A 500 (-3.6A)
None
 1.17A 5wwsA-1u7wA:
3.4		 5wwsA-1u7wA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC
(Escherichia
coli) 		5 / 12 CYH A 274
ALA A 276
PRO A 197
GLY A 236
GLY A 326
 None
None
None
None
CTP  A 500 (-3.6A)
 1.06A 5wwsB-1u7wA:
3.2		 5wwsB-1u7wA:
18.96