SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1u8s GLYCINE CLEAVAGE
SYSTEM
TRANSCRIPTIONAL
REPRESSOR, PUTATIVE
(Vibrio
cholerae) 		4 / 6 SER A 146
ALA A 122
THR A  93
ASN A 180
 None
 1.00A 1yvpB-1u8sA:
undetectable		 1yvpB-1u8sA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1u8s GLYCINE CLEAVAGE
SYSTEM
TRANSCRIPTIONAL
REPRESSOR, PUTATIVE
(Vibrio
cholerae) 		5 / 12 ILE A 143
LEU A 175
PHE A 113
PHE A 110
LEU A 169
 None
 1.29A 2w3mB-1u8sA:
undetectable		 2w3mB-1u8sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 1u8s GLYCINE CLEAVAGE
SYSTEM
TRANSCRIPTIONAL
REPRESSOR, PUTATIVE
(Vibrio
cholerae) 		3 / 3 HIS A  87
HIS A  85
ILE A  35
 None
 0.71A 3u52A-1u8sA:
undetectable
3u52C-1u8sA:
0.0		 3u52A-1u8sA:
17.17
3u52C-1u8sA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1u8s GLYCINE CLEAVAGE
SYSTEM
TRANSCRIPTIONAL
REPRESSOR, PUTATIVE
(Vibrio
cholerae) 		5 / 9 LEU A 124
ALA A 147
VAL A  96
LEU A 175
ILE A 145
 None
 1.13A 3wsjA-1u8sA:
undetectable		 3wsjA-1u8sA:
20.30