SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 10 ASP X 353
VAL X 358
ILE X 349
GLY X 347
PRO X 371
 None
 1.23A 1d4sA-1u8xX:
undetectable		 1d4sA-1u8xX:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 8 TYR X 197
GLY X 204
LEU X 266
MET X 385
 None
 1.23A 1gsfA-1u8xX:
undetectable		 1gsfA-1u8xX:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 8 TYR X 197
GLY X 204
LEU X 266
MET X 385
 None
 1.23A 1gsfB-1u8xX:
undetectable		 1gsfB-1u8xX:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 8 TYR X 197
GLY X 204
LEU X 266
MET X 385
 None
 1.23A 1gsfD-1u8xX:
undetectable		 1gsfD-1u8xX:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 6 ILE X  50
PRO X  19
PHE X  17
ARG X 293
 None
None
NAD  X 900 (-4.2A)
NAD  X 900 ( 3.8A)
 1.40A 1oniA-1u8xX:
undetectable
1oniC-1u8xX:
undetectable		 1oniA-1u8xX:
16.04
1oniC-1u8xX:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 LEU X 394
THR X 395
ALA X 398
GLU X 401
ILE X 412
 None
 0.95A 1qknA-1u8xX:
undetectable		 1qknA-1u8xX:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 TRP X 205
LEU X 261
LYS X 222
 None
 1.22A 1yajK-1u8xX:
undetectable		 1yajK-1u8xX:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 10 TYR X  92
ALA X  93
ALA X 286
GLU X  99
ALA X  96
 NAD  X 900 (-4.4A)
None
None
None
None
 1.32A 2r2vC-1u8xX:
undetectable
2r2vF-1u8xX:
undetectable
2r2vG-1u8xX:
undetectable		 2r2vC-1u8xX:
5.96
2r2vF-1u8xX:
5.96
2r2vG-1u8xX:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 ALA X 142
VAL X  83
ILE X 131
PHE X  77
LYS X 137
 None
 1.17A 2v95A-1u8xX:
undetectable		 2v95A-1u8xX:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 GLN X 381
THR X 207
GLY X 199
GLY X 204
ASN X 351
 None
 1.10A 2zw9B-1u8xX:
3.4		 2zw9B-1u8xX:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 LEU X 430
ALA X 286
VAL X 417
ILE X 426
THR X 416
 None
 1.03A 3czhB-1u8xX:
undetectable		 3czhB-1u8xX:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 GLY X  12
SER X  15
THR X  18
ASP X  41
ILE X 131
 NAD  X 900 (-3.6A)
NAD  X 900 (-2.3A)
None
NAD  X 900 (-2.7A)
None
 1.32A 3iv6B-1u8xX:
3.6		 3iv6B-1u8xX:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 GLY X  12
ASN X  42
PHE X  17
ILE X  10
GLY X  14
 NAD  X 900 (-3.6A)
NAD  X 900 (-3.5A)
NAD  X 900 (-4.2A)
None
NAD  X 900 (-3.4A)
 1.35A 3ps9A-1u8xX:
2.6		 3ps9A-1u8xX:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 GLY X  14
TYR X 120
SER X 124
VAL X 154
VAL X 128
 NAD  X 900 (-3.4A)
None
None
None
None
 1.26A 4ffwA-1u8xX:
undetectable		 4ffwA-1u8xX:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 GLY X  14
TYR X 120
SER X 124
VAL X 154
VAL X 128
 NAD  X 900 (-3.4A)
None
None
None
None
 1.27A 4ffwB-1u8xX:
undetectable		 4ffwB-1u8xX:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 8 PRO X 174
VAL X 175
ARG X 190
GLY X 199
 None
 1.02A 4mk4A-1u8xX:
1.8		 4mk4A-1u8xX:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 8 PRO X 174
VAL X 175
ARG X 190
GLY X 204
 None
 0.88A 4mk4A-1u8xX:
1.8		 4mk4A-1u8xX:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 GLY X  13
GLY X  14
ASP X  41
PHE X  77
ILE X  10
 None
NAD  X 900 (-3.4A)
NAD  X 900 (-2.7A)
None
None
 1.15A 4pghD-1u8xX:
2.3		 4pghD-1u8xX:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 8 GLY X 121
ALA X 410
LEU X 411
GLY X 114
CYH X 113
 None
 1.20A 4zauA-1u8xX:
undetectable		 4zauA-1u8xX:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 6 GLU X 111
GLY X 117
GLY X 116
ASP X  98
 G6P  X 902 ( 2.7A)
None
None
None
 0.98A 5a06D-1u8xX:
7.5		 5a06D-1u8xX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 4 ARG X  88
HIS X 202
ALA X 151
GLU X 111
 NAD  X 900 (-3.5A)
MN  X 700 ( 3.4A)
NAD  X 900 ( 4.8A)
G6P  X 902 ( 2.7A)
 1.10A 5a06A-1u8xX:
7.5
5a06F-1u8xX:
7.2		 5a06A-1u8xX:
21.43
5a06F-1u8xX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		5 / 12 GLY X  12
GLY X  14
ASP X  41
ILE X 131
GLU X 130
 NAD  X 900 (-3.6A)
NAD  X 900 (-3.4A)
NAD  X 900 (-2.7A)
None
NAD  X 900 ( 4.5A)
 0.80A 5bw4A-1u8xX:
2.9		 5bw4A-1u8xX:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 5 VAL X 389
VAL X 358
GLY X 199
PHE X 352
 None
 0.97A 5d4nA-1u8xX:
undetectable
5d4nC-1u8xX:
undetectable		 5d4nA-1u8xX:
13.38
5d4nC-1u8xX:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 ILE X  21
ILE X  50
MET X  84
 None
 0.70A 5i9yA-1u8xX:
undetectable		 5i9yA-1u8xX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		4 / 6 ILE X 170
GLY X 204
ASN X 263
ILE X 342
 None
 1.00A 5j4nB-1u8xX:
undetectable		 5j4nB-1u8xX:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 LEU X 145
THR X 335
ASN X 334
 None
 0.70A 6baaE-1u8xX:
undetectable		 6baaE-1u8xX:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 LEU X 168
THR X 335
ASN X 334
 None
 0.66A 6baaE-1u8xX:
undetectable		 6baaE-1u8xX:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 LEU X 145
THR X 335
ASN X 334
 None
 0.70A 6baaF-1u8xX:
undetectable		 6baaF-1u8xX:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 LEU X 168
THR X 335
ASN X 334
 None
 0.66A 6baaF-1u8xX:
undetectable		 6baaF-1u8xX:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 LEU X 145
THR X 335
ASN X 334
 None
 0.71A 6baaG-1u8xX:
undetectable		 6baaG-1u8xX:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 LEU X 168
THR X 335
ASN X 334
 None
 0.67A 6baaG-1u8xX:
undetectable		 6baaG-1u8xX:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 LEU X 145
THR X 335
ASN X 334
 None
 0.71A 6baaH-1u8xX:
undetectable		 6baaH-1u8xX:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE
(Bacillus
subtilis) 		3 / 3 LEU X 168
THR X 335
ASN X 334
 None
 0.67A 6baaH-1u8xX:
undetectable		 6baaH-1u8xX:
14.85