SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		4 / 4 THR A 173
LEU A 174
VAL A 144
LEU A 197
 None
 0.90A 1fbmB-1u9cA:
undetectable		 1fbmB-1u9cA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		4 / 8 THR A  10
GLY A  97
GLY A 131
GLY A 128
 None
 0.72A 1jhqA-1u9cA:
4.3		 1jhqA-1u9cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 218
LYS A 212
VAL A 214
 None
 0.93A 1l2iA-1u9cA:
undetectable		 1l2iA-1u9cA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 128
THR A 173
LEU A 174
LEU A 108
PHE A 168
 None
 1.17A 1mx1C-1u9cA:
undetectable		 1mx1C-1u9cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 112
PHE A 115
ALA A 116
LEU A 132
 None
 0.56A 1ukbA-1u9cA:
4.0		 1ukbA-1u9cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 132
LEU A 112
ILE A 198
THR A 209
LEU A 170
 None
 1.34A 2ft9A-1u9cA:
undetectable		 2ft9A-1u9cA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 112
LEU A 132
LEU A 174
ILE A  90
THR A 148
 None
 1.11A 2qd3A-1u9cA:
undetectable		 2qd3A-1u9cA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 197
ALA A 116
ASP A 118
ILE A  90
VAL A 111
ILE A 122
 None
 1.39A 2rkgA-1u9cA:
undetectable		 2rkgA-1u9cA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 124
GLY A  95
HIS A  96
THR A  98
MET A 166
 None
 1.35A 2xffA-1u9cA:
0.3		 2xffA-1u9cA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 12 TRP A 187
GLY A  95
HIS A  96
THR A  98
MET A 166
 None
 1.48A 2xffA-1u9cA:
0.3		 2xffA-1u9cA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  90
ALA A  89
ALA A  29
VAL A  30
VAL A   9
 None
 1.08A 2yvlC-1u9cA:
undetectable		 2yvlC-1u9cA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 112
LEU A 132
LEU A 174
ILE A  90
THR A 148
 None
 1.19A 4f4dA-1u9cA:
undetectable		 4f4dA-1u9cA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 198
GLY A 119
ALA A 216
GLN A 114
 None
 0.98A 4g0uB-1u9cA:
undetectable		 4g0uB-1u9cA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 192
GLY A 184
PHE A 190
SER A 151
GLY A 200
 None
 1.13A 4mm5A-1u9cA:
undetectable		 4mm5A-1u9cA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A 192
GLY A 184
PHE A 190
SER A 151
GLY A 200
 None
 1.12A 4mmcA-1u9cA:
0.0		 4mmcA-1u9cA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 192
GLY A 184
PHE A 190
SER A 151
GLY A 200
 None
 1.16A 4mmeA-1u9cA:
undetectable		 4mmeA-1u9cA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 192
GLY A 184
PHE A 190
SER A 151
GLY A 200
 None
 1.14A 4mmeB-1u9cA:
undetectable		 4mmeB-1u9cA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 192
GLY A 184
PHE A 190
SER A 151
GLY A 200
 None
 1.14A 4mmfA-1u9cA:
undetectable		 4mmfA-1u9cA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 192
GLY A 184
PHE A 190
SER A 151
GLY A 200
 None
 1.17A 4mmfB-1u9cA:
undetectable		 4mmfB-1u9cA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A  54
PHE A  28
HIS A  75
TYR A  32
 None
 1.14A 4pahA-1u9cA:
undetectable		 4pahA-1u9cA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		4 / 8 PHE A  28
SER A 206
PRO A  93
LEU A  23
 None
 0.95A 5dzkF-1u9cA:
undetectable
5dzkT-1u9cA:
undetectable		 5dzkF-1u9cA:
25.70
5dzkT-1u9cA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		4 / 4 ILE A 122
GLY A 131
ILE A 143
LEU A  92
 None
 0.90A 5dzkl-1u9cA:
undetectable
5dzkz-1u9cA:
undetectable		 5dzkl-1u9cA:
22.50
5dzkz-1u9cA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		6 / 12 SER A 130
GLY A 128
GLY A  22
GLY A  97
THR A  21
LYS A  20
 None
 1.47A 5ec8A-1u9cA:
undetectable		 5ec8A-1u9cA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 148
THR A 150
ARG A 183
GLN A 201
 None
 1.37A 5tzoA-1u9cA:
undetectable		 5tzoA-1u9cA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 148
THR A 150
ARG A 183
GLN A 201
 None
 1.38A 5tzoC-1u9cA:
undetectable		 5tzoC-1u9cA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 12 PRO A  53
VAL A   8
PHE A 168
PRO A 103
ILE A  47
 None
 1.48A 6becA-1u9cA:
0.0
6becB-1u9cA:
0.0
6becC-1u9cA:
0.0		 6becA-1u9cA:
17.25
6becB-1u9cA:
17.25
6becC-1u9cA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 197
PRO A 129
VAL A 144
SER A 172
LEU A 170
 None
 1.36A 6fdyU-1u9cA:
0.0		 6fdyU-1u9cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1u9c APC35852
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 175
PHE A 168
PHE A 181
 None
 0.97A 6nknC-1u9cA:
0.0
6nknJ-1u9cA:
undetectable		 6nknC-1u9cA:
20.44
6nknJ-1u9cA:
14.42