SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1u9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 236
ALA A 203
LEU A 227
LYS A 226
ILE A 210
 None
 1.07A 1draB-1u9zA:
undetectable		 1draB-1u9zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 102
ALA A 107
LEU A  83
TYR A  90
LEU A  88
 None
 1.23A 1qabF-1u9zA:
undetectable		 1qabF-1u9zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 236
ALA A 203
LEU A 227
LYS A 226
ILE A 210
 None
 1.07A 1rb3A-1u9zA:
undetectable		 1rb3A-1u9zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 208
ILE A 158
LEU A 160
LEU A 227
LEU A 184
 None
 1.23A 2a15A-1u9zA:
undetectable		 2a15A-1u9zA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 236
ALA A 203
LEU A 227
LYS A 226
ILE A 210
 None
 1.08A 3ql3A-1u9zA:
undetectable		 3ql3A-1u9zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A  62
ASN A  54
ALA A  85
THR A 121
 None
 0.94A 3t3sD-1u9zA:
undetectable		 3t3sD-1u9zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ASN A 123
VAL A 279
THR A 121
ILE A 120
 None
 1.42A 4retA-1u9zA:
undetectable		 4retA-1u9zA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ASN A 123
VAL A 279
THR A 121
ILE A 120
 None
 1.42A 4retC-1u9zA:
undetectable		 4retC-1u9zA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 108
PHE A 133
ILE A 105
ILE A 129
 None
 1.05A 5dzk4-1u9zA:
undetectable
5dzkg-1u9zA:
2.0
5dzkm-1u9zA:
1.4
5dzkn-1u9zA:
1.4		 5dzk4-1u9zA:
0.70
5dzkg-1u9zA:
22.44
5dzkm-1u9zA:
24.83
5dzkn-1u9zA:
24.83