SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ua2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 ASP A  79
GLY A  82
ALA A  59
ILE A  63
 None
 0.77A 1n49A-1ua2A:
undetectable		 1n49A-1ua2A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.02A 1v55P-1ua2A:
2.3
1v55W-1ua2A:
undetectable		 1v55P-1ua2A:
20.17
1v55W-1ua2A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 9 LEU A  18
VAL A  26
LEU A  77
LEU A  89
MET A  94
 ATP  A 381 (-4.4A)
ATP  A 381 (-4.0A)
None
None
None
 0.50A 1xkkA-1ua2A:
22.9		 1xkkA-1ua2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 9 LEU A  18
VAL A  26
LYS A  41
LEU A  77
LEU A  89
 ATP  A 381 (-4.4A)
ATP  A 381 (-4.0A)
ATP  A 381 (-2.9A)
None
None
 0.76A 1xkkA-1ua2A:
22.9		 1xkkA-1ua2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 8 LEU A  69
ILE A  74
PHE A 156
HIS A 131
 None
 0.71A 2azxA-1ua2A:
undetectable		 2azxA-1ua2A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.04A 2dysP-1ua2A:
2.1
2dysW-1ua2A:
undetectable		 2dysP-1ua2A:
20.17
2dysW-1ua2A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.07A 2eijC-1ua2A:
1.9
2eijJ-1ua2A:
undetectable		 2eijC-1ua2A:
20.17
2eijJ-1ua2A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.02A 2eijP-1ua2A:
2.1
2eijW-1ua2A:
undetectable		 2eijP-1ua2A:
20.17
2eijW-1ua2A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ASP A 137
ASN A 141
ASP A 155
GLY A  21
VAL A  26
 None
ATP  A 381 ( 4.6A)
ATP  A 381 ( 4.4A)
TPO  A 170 (-3.1A)
ATP  A 381 (-4.0A)
 1.25A 2fqyA-1ua2A:
undetectable		 2fqyA-1ua2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 5 LEU A 206
LEU A 269
MET A 118
MET A 292
 None
 1.00A 2oaxF-1ua2A:
undetectable		 2oaxF-1ua2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 VAL A  26
ALA A  39
ILE A  75
PHE A  91
MET A  94
LEU A 144
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
 0.61A 2y7jA-1ua2A:
23.0		 2y7jA-1ua2A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 10 VAL A  26
ALA A  39
ILE A  75
PHE A  91
MET A  94
LEU A 144
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
 0.55A 2y7jB-1ua2A:
23.3		 2y7jB-1ua2A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 10 VAL A  26
ALA A  39
ILE A  75
PHE A  91
MET A  94
LEU A 144
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
 0.59A 2y7jC-1ua2A:
23.1		 2y7jC-1ua2A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 10 VAL A  26
ALA A  39
ILE A  75
PHE A  91
MET A  94
LEU A 144
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
 0.54A 2y7jD-1ua2A:
23.2		 2y7jD-1ua2A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 8 LEU A  18
ALA A  39
MET A  94
LEU A 144
 ATP  A 381 (-4.4A)
ATP  A 381 (-3.6A)
None
None
 0.54A 2yfxA-1ua2A:
20.8		 2yfxA-1ua2A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 11 ILE A 114
LEU A 143
ASN A  73
LEU A 203
ILE A 202
 None
 1.13A 3a50B-1ua2A:
undetectable		 3a50B-1ua2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 11 ILE A 114
LEU A 143
ASN A  73
LEU A 203
ILE A 202
 None
 1.15A 3a50C-1ua2A:
undetectable		 3a50C-1ua2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.04A 3asnP-1ua2A:
2.6
3asnW-1ua2A:
undetectable		 3asnP-1ua2A:
20.17
3asnW-1ua2A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.04A 3asoP-1ua2A:
2.0
3asoW-1ua2A:
undetectable		 3asoP-1ua2A:
20.17
3asoW-1ua2A:
11.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A 204
LEU A 153
LEU A 143
HIS A 129
ASP A 195
 None
 0.93A 3gcsA-1ua2A:
24.7		 3gcsA-1ua2A:
33.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		3 / 3 GLU A 227
GLY A 230
THR A 231
 None
 0.48A 3iazA-1ua2A:
undetectable		 3iazA-1ua2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 8 LEU A 257
LEU A 203
ILE A 260
PHE A 261
 None
 0.94A 3ln1A-1ua2A:
undetectable		 3ln1A-1ua2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 LEU A 257
LEU A 203
ILE A 260
PHE A 261
 None
 0.95A 3ln1B-1ua2A:
undetectable		 3ln1B-1ua2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 11 ALA A  39
LYS A  41
PHE A  91
PHE A  93
MET A  94
LEU A 144
 ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
ATP  A 381 (-4.1A)
None
None
 0.63A 3miyA-1ua2A:
23.3		 3miyA-1ua2A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 9 ALA A  39
LYS A  41
PHE A  91
PHE A  93
MET A  94
LEU A 144
 ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
ATP  A 381 (-4.1A)
None
None
 0.59A 3miyB-1ua2A:
23.0		 3miyB-1ua2A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
PHE A  93
LEU A 144
ALA A 154
 ATP  A 381 (-4.4A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 (-4.1A)
None
None
 0.67A 3ms9A-1ua2A:
21.2		 3ms9A-1ua2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
PHE A  93
LEU A 144
ALA A 154
 ATP  A 381 (-4.4A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 (-4.1A)
None
None
 0.65A 3ms9B-1ua2A:
21.2		 3ms9B-1ua2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
PHE A  93
LEU A 144
ALA A 154
 ATP  A 381 (-4.4A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 (-4.1A)
None
None
 0.69A 3mssA-1ua2A:
21.4		 3mssA-1ua2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
PHE A  93
LEU A 144
ALA A 154
 ATP  A 381 (-4.4A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 (-4.1A)
None
None
 0.69A 3mssC-1ua2A:
21.4		 3mssC-1ua2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ILE A  74
ILE A  87
ILE A  43
ASP A 155
PHE A  91
 None
None
None
ATP  A 381 ( 4.4A)
None
 1.38A 3phaB-1ua2A:
undetectable		 3phaB-1ua2A:
19.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 12 VAL A  26
ALA A  39
ILE A  75
PHE A  91
LEU A 128
HIS A 135
ALA A 154
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
None
 0.82A 3rgfA-1ua2A:
9.0		 3rgfA-1ua2A:
35.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 12 VAL A  26
ALA A  39
LEU A  66
ILE A  75
PHE A  91
LEU A 128
ALA A 154
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
None
None
None
 0.72A 3rgfA-1ua2A:
9.0		 3rgfA-1ua2A:
35.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 9 ALA A  39
PHE A  91
PHE A  93
ASP A  97
LEU A 144
 ATP  A 381 (-3.6A)
None
ATP  A 381 (-4.1A)
ATP  A 381 ( 4.9A)
None
 0.70A 3ti1A-1ua2A:
34.2		 3ti1A-1ua2A:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 8 VAL A  26
LYS A  41
ILE A  75
PHE A  91
 ATP  A 381 (-4.0A)
ATP  A 381 (-2.9A)
None
None
 0.69A 3warA-1ua2A:
25.3		 3warA-1ua2A:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 11 LEU A  18
GLY A  19
GLY A  21
VAL A  26
ALA A  39
LEU A 144
 ATP  A 381 (-4.4A)
ATP  A 381 ( 3.9A)
TPO  A 170 (-3.1A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
 0.72A 4ckiA-1ua2A:
21.7		 4ckiA-1ua2A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 11 PHE A 295
LEU A 206
LEU A 203
ILE A 202
LEU A 151
 None
 1.10A 4dm8A-1ua2A:
0.0		 4dm8A-1ua2A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 5 TYR A 294
THR A 228
LEU A 213
MET A 196
 None
 1.28A 4mbsB-1ua2A:
undetectable		 4mbsB-1ua2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 VAL A  26
ALA A  39
LYS A  41
LEU A 144
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
 0.78A 4o0uA-1ua2A:
8.0		 4o0uA-1ua2A:
28.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 8 VAL A  26
ALA A  39
ASP A  97
ASN A 142
LEU A 144
 ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 ( 4.9A)
ATP  A 381 (-3.7A)
None
 0.60A 4ogrA-1ua2A:
31.3		 4ogrA-1ua2A:
38.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 LEU A  18
ALA A  39
MET A  94
LEU A 144
 ATP  A 381 (-4.4A)
ATP  A 381 (-3.6A)
None
None
 0.68A 4wboC-1ua2A:
21.1		 4wboC-1ua2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 GLY A 265
ALA A 204
ILE A 272
LEU A 268
LEU A 269
 None
 1.21A 4xj7A-1ua2A:
undetectable
4xj7B-1ua2A:
undetectable		 4xj7A-1ua2A:
20.87
4xj7B-1ua2A:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 ALA A  39
LYS A  41
MET A  94
LEU A 144
 ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
None
 0.59A 4xoyA-1ua2A:
11.4		 4xoyA-1ua2A:
35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 8 LEU A  18
GLY A  19
VAL A  26
ALA A  39
MET A  94
 ATP  A 381 (-4.4A)
ATP  A 381 ( 3.9A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
 0.45A 4zauA-1ua2A:
21.5		 4zauA-1ua2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 ALA A  39
PHE A  93
LEU A 144
ALA A 154
ASP A 155
 ATP  A 381 (-3.6A)
ATP  A 381 (-4.1A)
None
None
ATP  A 381 ( 4.4A)
 1.41A 5ajqB-1ua2A:
24.9		 5ajqB-1ua2A:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 8 ALA A 116
LEU A 206
LEU A 145
LEU A  98
 None
 0.74A 5jqbA-1ua2A:
undetectable
5jqbB-1ua2A:
undetectable		 5jqbA-1ua2A:
21.07
5jqbB-1ua2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 5 VAL A  38
THR A  34
ASP A  79
LEU A  78
 None
 1.28A 5m0iB-1ua2A:
0.0		 5m0iB-1ua2A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 ILE A 272
ALA A 204
LEU A 207
ILE A 114
 None
 0.63A 5mvmB-1ua2A:
undetectable
5mvmC-1ua2A:
undetectable		 5mvmB-1ua2A:
14.09
5mvmC-1ua2A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 LEU A  69
GLY A  76
LEU A 128
LEU A 125
ASN A  73
LEU A 153
 None
 1.28A 5nfjA-1ua2A:
undetectable		 5nfjA-1ua2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 LEU A  69
GLY A  76
LEU A 128
ASN A  73
LEU A 153
 None
 1.03A 5nfjB-1ua2A:
undetectable		 5nfjB-1ua2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 LEU A  69
GLY A  76
LEU A 128
ASN A  73
LEU A 153
 None
 1.02A 5nfjC-1ua2A:
undetectable		 5nfjC-1ua2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.03A 5w97C-1ua2A:
2.2
5w97J-1ua2A:
undetectable		 5w97C-1ua2A:
20.17
5w97J-1ua2A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.09A 5x19P-1ua2A:
1.8		 5x19P-1ua2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 LEU A  18
GLY A  19
VAL A  26
ALA A  39
PHE A  91
ALA A 154
 ATP  A 381 (-4.4A)
ATP  A 381 ( 3.9A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
 0.46A 5xv7A-1ua2A:
24.4		 5xv7A-1ua2A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 12 LEU A  18
GLY A  19
VAL A  26
ALA A  39
LYS A  41
LEU A  89
LEU A 144
 ATP  A 381 (-4.4A)
ATP  A 381 ( 3.9A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
None
 0.73A 5yu9A-1ua2A:
22.1		 5yu9A-1ua2A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 GLY A  19
VAL A  26
ALA A  39
LYS A  41
LEU A  89
LEU A 144
 ATP  A 381 ( 3.9A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
None
 0.73A 5yu9B-1ua2A:
22.2		 5yu9B-1ua2A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 ALA A 116
LEU A 206
LEU A 145
THR A 302
LEU A  98
 None
 0.89A 6f5uA-1ua2A:
undetectable
6f5uB-1ua2A:
0.0		 6f5uA-1ua2A:
14.02
6f5uB-1ua2A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 11 ASP A 155
ALA A 154
LEU A 138
HIS A 135
SER A 161
 ATP  A 381 ( 4.4A)
None
None
None
ATP  A 381 (-3.2A)
 1.18A 6ieyA-1ua2A:
undetectable
6ieyB-1ua2A:
undetectable		 6ieyA-1ua2A:
21.35
6ieyB-1ua2A:
21.35