SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ua4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 6 GLN A 113
ASP A 440
VAL A 436
GLY A 111
 GLC  A1457 ( 2.8A)
BGC  A2457 ( 2.7A)
BGC  A2457 ( 4.9A)
GLC  A1457 ( 3.5A)
 1.27A 1ekjC-1ua4A:
undetectable
1ekjD-1ua4A:
undetectable		 1ekjC-1ua4A:
19.01
1ekjD-1ua4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 6 ASP A 440
VAL A 436
GLY A 111
GLN A 113
 BGC  A2457 ( 2.7A)
BGC  A2457 ( 4.9A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 2.8A)
 1.27A 1ekjC-1ua4A:
undetectable
1ekjD-1ua4A:
undetectable		 1ekjC-1ua4A:
19.01
1ekjD-1ua4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 6 ASN A  30
ASN A  32
ILE A 116
GLY A 111
 GLC  A1457 (-4.2A)
GLC  A1457 ( 3.5A)
None
GLC  A1457 ( 3.5A)
 0.96A 1oniA-1ua4A:
undetectable
1oniB-1ua4A:
undetectable		 1oniA-1ua4A:
17.55
1oniB-1ua4A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 6 ASN A  30
ASN A  32
ILE A 116
GLY A 111
 GLC  A1457 (-4.2A)
GLC  A1457 ( 3.5A)
None
GLC  A1457 ( 3.5A)
 1.02A 1oniD-1ua4A:
undetectable
1oniF-1ua4A:
undetectable		 1oniD-1ua4A:
17.55
1oniF-1ua4A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 10 GLY A  75
VAL A  56
TRP A 103
LEU A  44
ALA A  51
 None
 1.43A 1pbcA-1ua4A:
3.0		 1pbcA-1ua4A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 364
ALA A 365
LEU A 367
SER A 445
 None
 1.05A 1sbrA-1ua4A:
0.0
1sbrB-1ua4A:
0.0		 1sbrA-1ua4A:
20.29
1sbrB-1ua4A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 8 LYS A 250
VAL A 249
TYR A  29
LEU A 209
 None
 0.88A 1z2bB-1ua4A:
4.5		 1z2bB-1ua4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 7 SER A 201
LEU A  89
PRO A 271
GLY A 233
 None
 1.02A 2ddwB-1ua4A:
13.0		 2ddwB-1ua4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 265
LEU A 231
ILE A 248
ARG A 216
 None
 1.09A 2hc4A-1ua4A:
0.0		 2hc4A-1ua4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
ALA A 268
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
BGC  A2457 ( 4.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.95A 2pkkA-1ua4A:
19.2		 2pkkA-1ua4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.37A 2pkkA-1ua4A:
19.2		 2pkkA-1ua4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.37A 2pkmA-1ua4A:
19.0		 2pkmA-1ua4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 ILE A 339
ILE A 299
LEU A 403
 None
 0.51A 2prgA-1ua4A:
undetectable		 2prgA-1ua4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 129
ALA A 114
VAL A  25
GLY A 122
ILE A 384
 None
 0.86A 2v0zO-1ua4A:
undetectable		 2v0zO-1ua4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 GLU A 352
SER A 288
VAL A 289
 None
 0.82A 3eeoA-1ua4A:
3.0		 3eeoA-1ua4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 11 THR A 324
VAL A 289
LEU A 283
TYR A 419
THR A 334
 None
 1.17A 3elzB-1ua4A:
0.0		 3elzB-1ua4A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 THR A 324
VAL A 289
LEU A 283
TYR A 419
THR A 334
 None
 1.18A 3elzC-1ua4A:
undetectable		 3elzC-1ua4A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 9 GLY A 115
ILE A 149
VAL A 131
VAL A 133
GLN A 140
 None
 1.26A 3fi0M-1ua4A:
undetectable		 3fi0M-1ua4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 GLY A 115
ILE A 130
VAL A 129
 None
 0.49A 3nv6A-1ua4A:
undetectable		 3nv6A-1ua4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 GLY A 233
ILE A 248
VAL A 249
 None
 0.52A 3nv6A-1ua4A:
undetectable		 3nv6A-1ua4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 289
LEU A 296
MET A 300
ILE A 299
 None
 0.79A 3rfmA-1ua4A:
0.0		 3rfmA-1ua4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 7 ARG A 183
ASN A 196
ALA A  86
GLY A 439
ILE A 438
 None
None
AMP  A1456 ( 3.8A)
AMP  A1456 (-2.8A)
AMP  A1456 (-3.1A)
 1.43A 3spkB-1ua4A:
undetectable		 3spkB-1ua4A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 381
PHE A 364
ALA A 365
LEU A 120
 None
 1.00A 3t3zA-1ua4A:
undetectable		 3t3zA-1ua4A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		6 / 12 ASP A  34
GLY A 111
GLY A 112
ARG A 197
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
AMP  A1456 ( 4.3A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.61A 3uboA-1ua4A:
24.3		 3uboA-1ua4A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.46A 3uq6A-1ua4A:
24.3		 3uq6A-1ua4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.51A 3vaqA-1ua4A:
24.3		 3vaqA-1ua4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.49A 3vasA-1ua4A:
24.4		 3vasA-1ua4A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.54A 3vasB-1ua4A:
22.3		 3vasB-1ua4A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 316
GLY A  84
TYR A 344
 None
None
AMP  A1456 (-4.6A)
 0.79A 3w9tC-1ua4A:
undetectable		 3w9tC-1ua4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 316
GLY A  84
TYR A 344
 None
None
AMP  A1456 (-4.6A)
 0.78A 3w9tG-1ua4A:
undetectable		 3w9tG-1ua4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 381
TYR A 125
VAL A  19
ALA A 446
SER A 444
 None
 1.47A 4a84A-1ua4A:
0.4		 4a84A-1ua4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 HIS A 342
GLU A 293
ASN A 196
 AMP  A1456 (-4.1A)
None
None
 1.05A 4bupB-1ua4A:
undetectable		 4bupB-1ua4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLN A 113
GLN A 235
ASN A 206
THR A 207
 GLC  A1457 ( 2.8A)
BGC  A2457 ( 4.9A)
None
None
 1.33A 4d1yA-1ua4A:
5.0
4d1yB-1ua4A:
4.7		 4d1yA-1ua4A:
19.35
4d1yB-1ua4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.49A 4dc3B-1ua4A:
24.4		 4dc3B-1ua4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 11 GLY A 115
ALA A 118
ILE A 149
HIS A 132
LEU A 136
 None
 1.06A 4dt8A-1ua4A:
undetectable		 4dt8A-1ua4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.38A 4e3aB-1ua4A:
24.6		 4e3aB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.39A 4jksA-1ua4A:
24.6		 4jksA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.39A 4jksB-1ua4A:
24.5		 4jksB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.39A 4jkuA-1ua4A:
24.6		 4jkuA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.39A 4k8cA-1ua4A:
24.6		 4k8cA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.38A 4k8cB-1ua4A:
24.6		 4k8cB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.40A 4k8kA-1ua4A:
24.6		 4k8kA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.40A 4k8kB-1ua4A:
24.6		 4k8kB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.39A 4kahA-1ua4A:
24.6		 4kahA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.38A 4kahB-1ua4A:
24.6		 4kahB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.39A 4kalA-1ua4A:
24.6		 4kalA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.40A 4kalB-1ua4A:
24.6		 4kalB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.38A 4kanA-1ua4A:
24.6		 4kanA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.38A 4kanB-1ua4A:
24.5		 4kanB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.38A 4kbeA-1ua4A:
24.5		 4kbeA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.37A 4kbeB-1ua4A:
24.6		 4kbeB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 8 LEU A 145
ARG A 109
SER A 445
VAL A 436
GLY A 437
 None
None
None
BGC  A2457 ( 4.9A)
BGC  A2457 ( 4.0A)
 1.22A 4klrB-1ua4A:
2.3		 4klrB-1ua4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.39A 4lbgA-1ua4A:
24.6		 4lbgA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.38A 4lbgB-1ua4A:
24.6		 4lbgB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.37A 4lcaA-1ua4A:
24.6		 4lcaA-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
ILE A 178
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
None
BGC  A2457 ( 2.7A)
 0.37A 4lcaB-1ua4A:
24.5		 4lcaB-1ua4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 8 VAL A 358
LEU A 362
TYR A 347
VAL A 323
THR A 324
 None
None
AMP  A1456 (-4.8A)
None
None
 1.33A 4ma7A-1ua4A:
undetectable		 4ma7A-1ua4A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 6 VAL A 282
LEU A 283
LEU A 234
PHE A 219
 None
 0.95A 4o1zA-1ua4A:
undetectable		 4o1zA-1ua4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 360
ILE A 442
SER A 443
HIS A 340
LEU A 367
 None
 1.36A 4pooA-1ua4A:
4.0		 4pooA-1ua4A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 8 ASN A  30
LEU A 237
LEU A 265
ILE A 279
 GLC  A1457 (-4.2A)
None
None
None
 0.81A 4r38D-1ua4A:
undetectable		 4r38D-1ua4A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_ACTA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 4 ALA A 331
LYS A 332
TYR A 419
GLU A 417
 None
 1.23A 4rvdA-1ua4A:
3.4		 4rvdA-1ua4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_ACTA504_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 4 ALA A 331
LYS A 332
TYR A 419
GLU A 417
 None
 1.29A 4rvgA-1ua4A:
3.5		 4rvgA-1ua4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 8 ALA A 446
ALA A 365
ILE A 442
TYR A 347
PHE A 341
 None
None
None
AMP  A1456 (-4.8A)
None
 1.41A 4v1fA-1ua4A:
undetectable
4v1fB-1ua4A:
undetectable		 4v1fA-1ua4A:
13.33
4v1fB-1ua4A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 5 PHE A 144
HIS A 132
LEU A  27
PRO A 164
 None
 1.37A 5csyB-1ua4A:
2.4		 5csyB-1ua4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLU A 266
SER A 232
GLY A  28
THR A 208
 None
 0.99A 5flcB-1ua4A:
0.0		 5flcB-1ua4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 8 GLU A 266
SER A 232
GLY A  28
THR A 208
 None
 0.99A 5flcF-1ua4A:
0.0		 5flcF-1ua4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 5 GLU A 352
THR A 351
THR A 454
LEU A 228
 None
 1.26A 5hm8A-1ua4A:
4.4		 5hm8A-1ua4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 5 GLU A 352
THR A 351
THR A 454
LEU A 228
 None
 1.25A 5hm8D-1ua4A:
4.8		 5hm8D-1ua4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 5 GLU A 352
THR A 351
THR A 454
LEU A 228
 None
 1.26A 5hm8G-1ua4A:
3.9		 5hm8G-1ua4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A  34
GLY A 111
GLY A 112
GLY A 437
ASP A 440
 GLC  A1457 ( 2.8A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 2.7A)
 0.40A 5kb5A-1ua4A:
25.2		 5kb5A-1ua4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 440
GLY A 437
ALA A 268
GLY A 111
ASP A  34
 BGC  A2457 ( 2.7A)
BGC  A2457 ( 4.0A)
BGC  A2457 ( 4.7A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 2.8A)
 0.72A 5kb5A-1ua4A:
25.2		 5kb5A-1ua4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 6 ILE A 428
ALA A 370
ILE A 438
TYR A 347
 AMP  A1456 (-3.9A)
None
AMP  A1456 (-3.1A)
AMP  A1456 (-4.8A)
 0.79A 5mvmB-1ua4A:
undetectable
5mvmC-1ua4A:
undetectable		 5mvmB-1ua4A:
9.67
5mvmC-1ua4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 360
GLU A 450
LEU A 403
LEU A 348
ALA A 349
 None
 1.20A 5nd7B-1ua4A:
4.1		 5nd7B-1ua4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 233
ASP A 440
GLY A 111
ASN A  32
ILE A 116
 None
BGC  A2457 ( 2.7A)
GLC  A1457 ( 3.5A)
GLC  A1457 ( 3.5A)
None
 0.84A 5vopA-1ua4A:
3.3		 5vopA-1ua4A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 7 ILE A  48
LEU A  74
ARG A 186
LEU A  39
 None
 0.95A 5zcqA-1ua4A:
undetectable
5zcqJ-1ua4A:
undetectable		 5zcqA-1ua4A:
20.36
5zcqJ-1ua4A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 145
THR A  31
ASN A  32
 None
None
GLC  A1457 ( 3.5A)
 0.71A 6baaE-1ua4A:
undetectable		 6baaE-1ua4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 145
THR A  31
ASN A  32
 None
None
GLC  A1457 ( 3.5A)
 0.71A 6baaF-1ua4A:
1.9		 6baaF-1ua4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 145
THR A  31
ASN A  32
 None
None
GLC  A1457 ( 3.5A)
 0.72A 6baaG-1ua4A:
2.0		 6baaG-1ua4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 145
THR A  31
ASN A  32
 None
None
GLC  A1457 ( 3.5A)
 0.72A 6baaH-1ua4A:
undetectable		 6baaH-1ua4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1ua4 ADP-DEPENDENT
GLUCOKINASE
(Pyrococcus
furiosus) 		4 / 7 VAL A  70
ILE A  77
GLY A 111
ARG A 102
 None
None
GLC  A1457 ( 3.5A)
None
 0.85A 6hd6B-1ua4A:
undetectable		 6hd6B-1ua4A:
10.33