SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uaa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.83A 1hxbB-1uaaA:
undetectable		 1hxbB-1uaaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 6 GLY A   6
GLN A   8
VAL A  31
ALA A  10
 None
 1.03A 1p6kA-1uaaA:
undetectable		 1p6kA-1uaaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 10 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.87A 1sdvA-1uaaA:
undetectable		 1sdvA-1uaaA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		3 / 3 ASP A 218
TYR A 248
GLU A 591
 None
 0.83A 1vm1A-1uaaA:
undetectable		 1vm1A-1uaaA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 453
LEU A 445
GLU A 423
GLY A 422
ALA A 425
 None
 1.15A 2bm9C-1uaaA:
2.4		 2bm9C-1uaaA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		3 / 3 ASP A 590
ASP A 243
ASN A 293
 None
 0.63A 2bm9D-1uaaA:
undetectable		 2bm9D-1uaaA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 453
LEU A 445
GLU A 423
GLY A 422
ALA A 425
 None
 1.07A 2br4A-1uaaA:
2.4		 2br4A-1uaaA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 453
LEU A 445
GLU A 423
GLY A 422
ALA A 425
 None
 1.04A 2br4D-1uaaA:
2.3		 2br4D-1uaaA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 11 LEU A 186
ALA A 103
SER A 106
LEU A 107
ASP A 398
 None
 1.23A 2c12F-1uaaA:
undetectable		 2c12F-1uaaA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.86A 2nmzA-1uaaA:
undetectable		 2nmzA-1uaaA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.86A 2nmzB-1uaaA:
undetectable		 2nmzB-1uaaA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.88A 2o4nA-1uaaA:
undetectable		 2o4nA-1uaaA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 11 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.88A 2o4pA-1uaaA:
undetectable		 2o4pA-1uaaA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 6 SER A 431
PHE A 402
ILE A 405
PHE A 456
 None
 1.19A 2qeiA-1uaaA:
0.0		 2qeiA-1uaaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		3 / 3 ARG A 501
ARG A 380
PRO A 381
 None
 1.00A 2wljA-1uaaA:
undetectable		 2wljA-1uaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 7 LEU A 181
ILE A  92
ALA A  51
ILE A 208
 None
 0.78A 2xkwA-1uaaA:
undetectable		 2xkwA-1uaaA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 6 ILE A  50
TYR A  45
LEU A 268
PHE A 265
 None
 1.17A 3adsA-1uaaA:
undetectable		 3adsA-1uaaA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 6 VAL A 530
VAL A 531
PHE A 509
ARG A 537
 None
 1.15A 3bjwF-1uaaA:
undetectable		 3bjwF-1uaaA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 10 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.87A 3el5A-1uaaA:
undetectable		 3el5A-1uaaA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 5 HIS A 335
ASP A 344
TYR A 342
PRO A 368
 None
 1.19A 3fo7A-1uaaA:
undetectable		 3fo7A-1uaaA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.82A 3k4vA-1uaaA:
undetectable		 3k4vA-1uaaA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.83A 3k4vB-1uaaA:
undetectable		 3k4vB-1uaaA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.89A 3k4vC-1uaaA:
undetectable		 3k4vC-1uaaA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 1.04A 3ln1A-1uaaA:
undetectable		 3ln1A-1uaaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 1.03A 3ln1B-1uaaA:
undetectable		 3ln1B-1uaaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 1.04A 3ln1C-1uaaA:
2.0		 3ln1C-1uaaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 1.04A 3ln1D-1uaaA:
undetectable		 3ln1D-1uaaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.83A 3ndtB-1uaaA:
undetectable		 3ndtB-1uaaA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 229
LEU A 193
LEU A 192
ILE A 187
GLY A  88
 None
 1.14A 3q95A-1uaaA:
undetectable		 3q95A-1uaaA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 11 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.92A 3spkA-1uaaA:
undetectable		 3spkA-1uaaA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.91A 3spkB-1uaaA:
undetectable		 3spkB-1uaaA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.80A 3tkwB-1uaaA:
undetectable		 3tkwB-1uaaA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.87A 3tl9B-1uaaA:
undetectable		 3tl9B-1uaaA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 9 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.95A 3u7sA-1uaaA:
undetectable		 3u7sA-1uaaA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.87A 4dqbA-1uaaA:
undetectable		 4dqbA-1uaaA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 11 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.78A 4njtC-1uaaA:
undetectable		 4njtC-1uaaA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.89A 4njuA-1uaaA:
undetectable		 4njuA-1uaaA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.89A 4njuC-1uaaA:
undetectable		 4njuC-1uaaA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 8 ALA A 435
GLY A 440
LEU A 441
LEU A 421
 None
 0.87A 4po0A-1uaaA:
undetectable		 4po0A-1uaaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA612_0
(SERUM ALBUMIN)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 4 SER A 582
HIS A 580
GLU A 592
PRO A 579
 None
 1.37A 5dbyA-1uaaA:
0.2		 5dbyA-1uaaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 1.02A 5jw1A-1uaaA:
1.8		 5jw1A-1uaaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 0.98A 5kirA-1uaaA:
undetectable		 5kirA-1uaaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 VAL A  31
ALA A  59
GLY A 241
ALA A  22
LEU A 273
 None
 0.98A 5kirB-1uaaA:
undetectable		 5kirB-1uaaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 5 THR A  83
ASN A  57
ASP A 538
LEU A 536
 None
 1.24A 5m0iB-1uaaA:
undetectable		 5m0iB-1uaaA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 6 ARG A 350
GLY A 576
GLU A 592
SER A 583
 None
 0.95A 5ny7A-1uaaA:
undetectable		 5ny7A-1uaaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		3 / 3 VAL A 239
VAL A 213
GLN A 223
 None
 0.66A 5qgjA-1uaaA:
undetectable		 5qgjA-1uaaA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		3 / 3 VAL A 239
VAL A 213
GLN A 223
 None
 0.63A 5qgmA-1uaaA:
undetectable		 5qgmA-1uaaA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		3 / 3 VAL A 239
VAL A 213
GLN A 223
 None
 0.71A 5qh9A-1uaaA:
undetectable		 5qh9A-1uaaA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		3 / 3 VAL A 239
VAL A 213
GLN A 223
 None
 0.72A 5qhcA-1uaaA:
undetectable		 5qhcA-1uaaA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		3 / 3 VAL A 239
VAL A 213
GLN A 223
 None
 0.72A 5qheA-1uaaA:
undetectable		 5qheA-1uaaA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		3 / 3 VAL A 239
VAL A 213
GLN A 223
 None
 0.69A 5qhgA-1uaaA:
undetectable		 5qhgA-1uaaA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		4 / 7 LEU A  71
ALA A  37
ILE A  50
LEU A  79
 None
 0.92A 5te8C-1uaaA:
undetectable		 5te8C-1uaaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 ILE A 289
SER A 280
PHE A 303
LEU A 290
LEU A 312
 None
 1.22A 6chgC-1uaaA:
undetectable		 6chgC-1uaaA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 LEU A 630
ALA A 596
ILE A 291
ILE A 283
PRO A 634
 None
 0.86A 6dilA-1uaaA:
undetectable		 6dilA-1uaaA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 10 SER A 222
LEU A 181
ILE A  92
PRO A 190
GLY A  88
 None
 1.31A 6dm0B-1uaaA:
4.1
6dm0C-1uaaA:
3.3		 6dm0B-1uaaA:
9.67
6dm0C-1uaaA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 ARG A 476
VAL A 475
LEU A 390
LEU A 508
LEU A 386
 None
 1.10A 6f6iA-1uaaA:
0.0
6f6iB-1uaaA:
undetectable		 6f6iA-1uaaA:
7.99
6f6iB-1uaaA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 GLY A  27
VAL A  31
VAL A 240
ARG A 278
GLN A 245
 None
 0.91A 6gneA-1uaaA:
undetectable		 6gneA-1uaaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)
(Escherichia
coli) 		5 / 12 GLY A  27
VAL A  31
VAL A 240
ARG A 278
GLN A 245
 None
 0.92A 6gneB-1uaaA:
undetectable		 6gneB-1uaaA:
22.01