SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 10 LEU A  67
ALA A  70
GLY A  17
PRO A  31
VAL A   8
 None
 0.90A 1hsgA-1uagA:
undetectable		 1hsgA-1uagA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 11 LEU A  67
ALA A  70
GLY A  17
PRO A  31
VAL A   8
 None
 0.96A 1hxwB-1uagA:
undetectable		 1hxwB-1uagA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 8 TYR A 358
LEU A 355
LEU A 408
SER A 410
 None
 1.00A 1i7zA-1uagA:
undetectable		 1i7zA-1uagA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 11 GLY A  88
ALA A  85
ASP A  86
THR A 165
VAL A  92
ILE A  91
 None
 1.28A 1ohrA-1uagA:
undetectable		 1ohrA-1uagA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 GLY A  17
GLY A  14
GLY A  42
ASP A  94
SER A  19
 None
UMA  A 963 ( 3.7A)
None
UMA  A 963 ( 4.9A)
None
 1.08A 1wg8A-1uagA:
3.1		 1wg8A-1uagA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 GLY A  17
GLY A  14
GLY A  42
ASP A  94
SER A  19
 None
UMA  A 963 ( 3.7A)
None
UMA  A 963 ( 4.9A)
None
 1.01A 1wg8B-1uagA:
3.3		 1wg8B-1uagA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 5 LEU A  67
GLY A  12
PRO A  31
VAL A   8
 None
UMA  A 963 ( 4.1A)
None
None
 0.83A 2aojA-1uagA:
undetectable		 2aojA-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 5 LEU A  67
GLY A  17
PRO A  31
VAL A   8
 None
 0.70A 2aojA-1uagA:
undetectable		 2aojA-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 7 LEU A  67
GLY A  17
PRO A  31
VAL A   8
 None
 0.77A 2aojB-1uagA:
undetectable		 2aojB-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 11 ASN A 271
TYR A 194
GLY A 111
THR A 217
THR A 180
 None
KCX  A 198 ( 4.2A)
KCX  A 198 ( 3.9A)
None
None
 1.34A 2f9wA-1uagA:
undetectable
2f9wB-1uagA:
1.1		 2f9wA-1uagA:
20.05
2f9wB-1uagA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 GLY A 345
GLY A 347
THR A 321
ASP A 372
GLU A 388
 None
 1.03A 2gluA-1uagA:
2.3		 2gluA-1uagA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 7 ALA A  65
ASN A   7
TRP A  61
LEU A  62
 None
SO4  A 965 (-3.9A)
None
None
 1.15A 2hzqA-1uagA:
undetectable		 2hzqA-1uagA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 ALA A 102
LEU A 147
ARG A  27
GLY A 137
LEU A 156
 None
None
None
UMA  A 963 (-4.3A)
None
 1.01A 2jfaB-1uagA:
undetectable		 2jfaB-1uagA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 12 LEU A  67
GLY A  93
ALA A  70
GLY A  17
PRO A  31
VAL A   8
 None
 1.19A 2q63A-1uagA:
undetectable		 2q63A-1uagA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 8 ARG A  32
ASP A  44
LEU A  43
GLY A  42
 SO4  A 965 (-3.5A)
None
None
None
 0.95A 2tsrB-1uagA:
undetectable		 2tsrB-1uagA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 12 LEU A  67
GLY A  93
ALA A  70
GLY A  17
PRO A  31
VAL A   8
 None
 1.19A 3bvbA-1uagA:
undetectable		 3bvbA-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		3 / 3 CYH A  20
PHE A  23
PHE A  24
 None
 0.47A 3cr5X-1uagA:
0.0		 3cr5X-1uagA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 12 GLY A  88
ALA A  85
ASP A  86
THR A 165
VAL A  92
ILE A  91
 None
 1.35A 3d1xA-1uagA:
undetectable		 3d1xA-1uagA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 12 GLY A  88
ALA A  85
ASP A  86
THR A 165
VAL A  92
ILE A  91
 None
 1.32A 3d1yA-1uagA:
undetectable		 3d1yA-1uagA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 ALA A 329
LEU A 341
LEU A 408
LEU A 409
LEU A 355
 None
 1.11A 3erdA-1uagA:
undetectable		 3erdA-1uagA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 10 ALA A 102
LEU A 146
LEU A 147
ARG A  27
LEU A 156
 None
 1.38A 3erdB-1uagA:
undetectable		 3erdB-1uagA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 7 LEU A 284
LEU A 169
VAL A 172
LEU A 147
 None
 0.86A 3g8iA-1uagA:
undetectable		 3g8iA-1uagA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 8 SER A  19
PHE A  23
VAL A  92
LEU A  67
 None
 1.15A 3jq7C-1uagA:
3.3		 3jq7C-1uagA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 12 LEU A  67
GLY A  93
ALA A  70
GLY A  17
PRO A  31
VAL A   8
 None
 1.23A 3jw2A-1uagA:
undetectable		 3jw2A-1uagA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 7 VAL A 335
VAL A 312
ASN A 363
GLY A 337
 None
 1.10A 3kmoB-1uagA:
undetectable		 3kmoB-1uagA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		3 / 3 SER A 325
ASP A 317
ASN A 316
 SO4  A 964 ( 4.9A)
None
None
 0.88A 3lsfB-1uagA:
undetectable
3lsfE-1uagA:
undetectable		 3lsfB-1uagA:
21.36
3lsfE-1uagA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		3 / 3 ASP A 317
ASN A 316
SER A 325
 None
None
SO4  A 964 ( 4.9A)
 0.82A 3lsfB-1uagA:
undetectable
3lsfE-1uagA:
undetectable		 3lsfB-1uagA:
21.36
3lsfE-1uagA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		3 / 3 ASP A 317
ASN A 316
SER A 325
 None
None
SO4  A 964 ( 4.9A)
 0.98A 3lslA-1uagA:
undetectable
3lslD-1uagA:
1.4		 3lslA-1uagA:
21.36
3lslD-1uagA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		3 / 3 SER A 325
ASP A 317
ASN A 316
 SO4  A 964 ( 4.9A)
None
None
 0.90A 3lslA-1uagA:
undetectable
3lslD-1uagA:
1.4		 3lslA-1uagA:
21.36
3lslD-1uagA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 12 ALA A 274
ALA A 272
ALA A 275
VAL A 209
ALA A 212
GLY A 231
 None
 1.39A 3mg0Y-1uagA:
undetectable
3mg0Z-1uagA:
undetectable		 3mg0Y-1uagA:
18.99
3mg0Z-1uagA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 12 LEU A  67
GLY A  93
ALA A  70
GLY A  17
PRO A  31
VAL A   8
 None
 1.23A 3tl9A-1uagA:
undetectable		 3tl9A-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 12 LEU A  67
GLY A  93
ALA A  70
GLY A  17
PRO A  31
VAL A   8
 None
 1.18A 3tl9B-1uagA:
undetectable		 3tl9B-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 11 ALA A 102
LEU A 147
ARG A  27
GLY A 137
LEU A 156
 None
None
None
UMA  A 963 (-4.3A)
None
 1.26A 3uudA-1uagA:
undetectable		 3uudA-1uagA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 7 ASP A  94
PHE A  98
GLY A 136
THR A  16
 UMA  A 963 ( 4.9A)
None
None
UMA  A 963 (-3.6A)
 1.04A 3vnsA-1uagA:
4.3		 3vnsA-1uagA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 PRO A  72
GLY A  73
ASP A  35
MET A  34
VAL A  33
 UMA  A 963 (-3.8A)
UMA  A 963 (-3.1A)
UMA  A 963 (-3.4A)
None
None
 1.04A 4b17A-1uagA:
2.1		 4b17A-1uagA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 11 LEU A  67
ALA A  70
GLY A  17
PRO A  31
VAL A   8
 None
 0.93A 4dqeA-1uagA:
undetectable		 4dqeA-1uagA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 6 PHE A 369
ALA A 412
THR A 326
LEU A 341
 None
 0.95A 4ejgD-1uagA:
undetectable		 4ejgD-1uagA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 8 LEU A 147
ARG A 100
VAL A  92
GLY A  93
 None
 0.99A 4klrB-1uagA:
2.7		 4klrB-1uagA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 GLY A 111
ASN A 178
ILE A 201
TYR A 202
LEU A 278
 KCX  A 198 ( 3.9A)
None
KCX  A 198 ( 3.6A)
None
None
 1.23A 4kosA-1uagA:
undetectable		 4kosA-1uagA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 GLY A 111
ASN A 178
ILE A 201
TYR A 202
LEU A 278
 KCX  A 198 ( 3.9A)
None
KCX  A 198 ( 3.6A)
None
None
 1.17A 4kotA-1uagA:
0.0		 4kotA-1uagA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 GLY A 111
ASN A 178
ILE A 201
TYR A 202
LEU A 278
 KCX  A 198 ( 3.9A)
None
KCX  A 198 ( 3.6A)
None
None
 1.22A 4kovA-1uagA:
undetectable		 4kovA-1uagA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 11 GLY A 111
ASN A 178
ILE A 201
TYR A 202
LEU A 278
 KCX  A 198 ( 3.9A)
None
KCX  A 198 ( 3.6A)
None
None
 1.17A 4koyA-1uagA:
0.0		 4koyA-1uagA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		3 / 3 LEU A 416
ARG A  37
MET A  34
 None
UMA  A 963 (-3.0A)
None
 0.94A 4m11C-1uagA:
undetectable		 4m11C-1uagA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 ILE A  74
THR A  36
LEU A  81
ASP A  59
LEU A  62
 UMA  A 963 ( 4.4A)
UMA  A 963 (-3.3A)
None
None
None
 1.46A 4pbhA-1uagA:
undetectable		 4pbhA-1uagA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 6 ILE A  68
VAL A  33
THR A  16
ARG A 100
 None
None
UMA  A 963 (-3.6A)
None
 1.17A 4xe5A-1uagA:
undetectable		 4xe5A-1uagA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 ALA A 102
LEU A 147
ARG A  27
GLY A 137
LEU A 156
 None
None
None
UMA  A 963 (-4.3A)
None
 0.99A 4xi3B-1uagA:
undetectable		 4xi3B-1uagA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 7 ASN A 240
LYS A 245
TYR A 269
LEU A 276
 None
 1.21A 4yv5A-1uagA:
undetectable		 4yv5A-1uagA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 7 ASN A 240
LYS A 245
TYR A 269
LEU A 276
 None
 1.12A 4yv5B-1uagA:
undetectable		 4yv5B-1uagA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 7 GLY A 404
ASP A 336
GLY A 311
GLU A 308
 None
 0.96A 4z53A-1uagA:
undetectable
4z53B-1uagA:
undetectable		 4z53A-1uagA:
21.64
4z53B-1uagA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 8 LEU A 359
LEU A 341
ALA A 412
LEU A 376
LEU A 379
 None
 1.02A 4z90A-1uagA:
undetectable
4z90B-1uagA:
undetectable
4z90C-1uagA:
undetectable
4z90D-1uagA:
undetectable
4z90E-1uagA:
undetectable		 4z90A-1uagA:
21.38
4z90B-1uagA:
21.38
4z90C-1uagA:
21.38
4z90D-1uagA:
21.38
4z90E-1uagA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		3 / 3 THR A 165
HIS A  53
LEU A  62
 None
 0.85A 5axdC-1uagA:
2.3		 5axdC-1uagA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		4 / 6 ALA A 174
THR A 175
VAL A 209
VAL A 122
 None
 0.94A 5eclA-1uagA:
undetectable		 5eclA-1uagA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 ILE A  89
ALA A  65
PHE A  24
LEU A  62
VAL A   9
 None
 1.21A 5hw4A-1uagA:
3.2		 5hw4A-1uagA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 11 ILE A  89
ALA A  65
PHE A  24
LEU A  62
VAL A   9
 None
 1.22A 5hw4B-1uagA:
1.9		 5hw4B-1uagA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 ILE A  89
ALA A  65
PHE A  24
LEU A  62
VAL A   9
 None
 1.16A 5hw4C-1uagA:
undetectable		 5hw4C-1uagA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		6 / 12 GLY A  88
ALA A  85
ASP A  86
THR A 165
VAL A  92
ILE A  91
 None
 1.31A 5kqxA-1uagA:
undetectable		 5kqxA-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 9 ALA A 102
LEU A 147
ARG A  27
GLY A 136
LEU A 156
 None
 1.46A 5wgqA-1uagA:
0.1		 5wgqA-1uagA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 LEU A  67
ALA A  70
GLY A  17
PRO A  31
VAL A   8
 None
 0.90A 6dilA-1uagA:
undetectable		 6dilA-1uagA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 12 THR A 119
HIS A 267
ASN A 178
LEU A 177
GLY A 111
 None
None
None
None
KCX  A 198 ( 3.9A)
 1.37A 6exiD-1uagA:
2.4		 6exiD-1uagA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE
(Escherichia
coli) 		5 / 11 ILE A  95
LEU A 141
GLY A 134
PHE A  98
ALA A 102
 None
 1.34A 6ieyA-1uagA:
2.4
6ieyB-1uagA:
2.4		 6ieyA-1uagA:
23.46
6ieyB-1uagA:
23.46