SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 12 ALA A 116
PHE A 162
ALA A 192
VAL A  54
LEU A  13
 None
 1.33A 1rbpA-1uaiA:
undetectable		 1rbpA-1uaiA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 12 LEU A 216
PHE A 162
ALA A 192
VAL A  54
LEU A  13
 None
 1.38A 1rbpA-1uaiA:
undetectable		 1rbpA-1uaiA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 11 LEU A 216
ALA A 116
ALA A 192
VAL A  54
LEU A  13
 None
 0.96A 3bszE-1uaiA:
0.0		 3bszE-1uaiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		4 / 4 ILE A 137
GLN A 178
VAL A 148
PHE A 128
 None
 0.96A 3ieoA-1uaiA:
0.0		 3ieoA-1uaiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 12 ALA A  86
SER A  87
PHE A 162
ILE A 118
PHE A 190
 None
 1.17A 4c49A-1uaiA:
undetectable		 4c49A-1uaiA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 11 VAL A  47
ALA A  42
PHE A  39
LEU A  13
VAL A  54
 None
 1.15A 4eilA-1uaiA:
undetectable		 4eilA-1uaiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 10 VAL A  47
ALA A  42
PHE A  39
LEU A  13
VAL A  54
 None
 1.12A 4eilB-1uaiA:
undetectable		 4eilB-1uaiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 11 VAL A  47
ALA A  42
PHE A  39
LEU A  13
VAL A  54
 None
 1.15A 4eilC-1uaiA:
undetectable		 4eilC-1uaiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 11 VAL A  47
ALA A  42
PHE A  39
LEU A  13
VAL A  54
 None
 1.15A 4eilE-1uaiA:
undetectable		 4eilE-1uaiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		3 / 3 TYR A  70
ARG A 129
HIS A 112
 None
 1.00A 4fubA-1uaiA:
undetectable		 4fubA-1uaiA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 12 VAL A  47
ALA A  42
PHE A  39
LEU A  13
VAL A  54
 None
 1.12A 4kyaB-1uaiA:
undetectable		 4kyaB-1uaiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 12 VAL A  47
ALA A  42
PHE A  39
LEU A  13
VAL A  54
 None
 1.12A 4kyaD-1uaiA:
undetectable		 4kyaD-1uaiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 12 VAL A  47
ALA A  42
PHE A  39
LEU A  13
VAL A  54
 None
 1.13A 4kyaF-1uaiA:
undetectable		 4kyaF-1uaiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		5 / 12 VAL A  47
ALA A  42
PHE A  39
LEU A  13
VAL A  54
 None
 1.12A 4kyaH-1uaiA:
undetectable		 4kyaH-1uaiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		3 / 3 GLU A 101
ALA A 102
PHE A 103
 None
 0.60A 4v1fA-1uaiA:
undetectable		 4v1fA-1uaiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		3 / 3 GLU A 101
ALA A 102
PHE A 103
 None
 0.64A 4v1fC-1uaiA:
undetectable		 4v1fC-1uaiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1uai POLYGULURONATE LYASE
(Corynebacterium
sp.) 		4 / 7 HIS A 223
ARG A  76
HIS A 119
GLU A  77
 None
 1.31A 6mn4F-1uaiA:
0.0		 6mn4F-1uaiA:
20.61