SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.37A 1d4fB-1uanA:
3.1		 1d4fB-1uanA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
THR A  38
GLU A  41
ASP A  12
GLY A  75
 None
 1.20A 1xwfD-1uanA:
2.2		 1xwfD-1uanA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		3 / 3 ALA A  25
THR A  32
PHE A 162
 None
 0.74A 2c6nB-1uanA:
undetectable		 2c6nB-1uanA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.46A 2zj0D-1uanA:
undetectable		 2zj0D-1uanA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 PRO A  11
TYR A 145
PHE A 177
TYR A 173
GLU A  15
 None
 1.16A 3q5pA-1uanA:
0.0		 3q5pA-1uanA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		3 / 3 GLY A  17
GLY A  19
THR A  21
 None
 0.45A 3si7B-1uanA:
undetectable		 3si7B-1uanA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		4 / 6 GLU A  15
GLY A  14
LEU A  62
GLU A 211
 None
 1.10A 3w9tB-1uanA:
undetectable		 3w9tB-1uanA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		4 / 6 GLU A  15
GLY A  14
LEU A  62
GLU A 211
 None
 1.09A 3w9tE-1uanA:
undetectable		 3w9tE-1uanA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		3 / 3 ARG A  51
ARG A  67
ASP A  13
 None
 0.97A 3wipG-1uanA:
undetectable
3wipH-1uanA:
undetectable		 3wipG-1uanA:
20.31
3wipH-1uanA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 PHE A 213
GLY A  19
GLY A  14
VAL A   6
ARG A 194
 None
 1.07A 4a6dA-1uanA:
undetectable		 4a6dA-1uanA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 PHE A 213
GLY A  19
GLY A  14
VAL A   6
ARG A 194
 None
 1.03A 4a6eA-1uanA:
2.6		 4a6eA-1uanA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		3 / 3 TYR A 173
ASP A  36
ASP A  74
 None
 0.88A 4a6eA-1uanA:
2.6		 4a6eA-1uanA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		4 / 5 GLY A  40
THR A  38
GLY A  75
GLU A  41
 None
 1.17A 4v20A-1uanA:
undetectable		 4v20A-1uanA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.46A 5hm8A-1uanA:
3.0		 5hm8A-1uanA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.46A 5hm8B-1uanA:
3.1		 5hm8B-1uanA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.46A 5hm8C-1uanA:
2.9		 5hm8C-1uanA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.46A 5hm8D-1uanA:
3.1		 5hm8D-1uanA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.45A 5hm8E-1uanA:
2.8		 5hm8E-1uanA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.46A 5hm8F-1uanA:
2.6		 5hm8F-1uanA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.45A 5hm8G-1uanA:
2.7		 5hm8G-1uanA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 HIS A  10
ASP A  13
HIS A 111
GLY A  43
PHE A 177
 None
 1.45A 5hm8H-1uanA:
undetectable		 5hm8H-1uanA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 ALA A 169
GLY A 147
GLY A  14
GLY A 190
VAL A 186
 None
 0.95A 5i73A-1uanA:
undetectable		 5i73A-1uanA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		5 / 12 ILE A  34
LEU A  87
LEU A  77
GLY A  75
LEU A   5
 None
 1.03A 5ienA-1uanA:
undetectable		 5ienA-1uanA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		4 / 4 LEU A  64
LEU A  22
SER A  31
ALA A  25
 None
 1.15A 5uunA-1uanA:
undetectable		 5uunA-1uanA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1uan HYPOTHETICAL PROTEIN
TT1542
(Thermus
thermophilus) 		4 / 5 ARG A  93
PHE A  66
LEU A   2
LEU A  37
 None
 1.18A 5veuH-1uanA:
undetectable		 5veuH-1uanA:
19.09