SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1uar RHODANESE
(Thermus
thermophilus) 		5 / 12 LEU A 125
GLY A 114
MET A 111
TYR A  85
LEU A  35
 None
 0.94A 1brpA-1uarA:
undetectable		 1brpA-1uarA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1uar RHODANESE
(Thermus
thermophilus) 		4 / 6 HIS A  40
ILE A  41
LYS A 117
VAL A  15
 None
 1.04A 1hk1A-1uarA:
undetectable		 1hk1A-1uarA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 1uar RHODANESE
(Thermus
thermophilus) 		4 / 7 GLN A 116
ASP A 212
LEU A   9
ASN A  90
 None
 1.19A 1ig3A-1uarA:
undetectable
1ig3B-1uarA:
undetectable		 1ig3A-1uarA:
23.05
1ig3B-1uarA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 1uar RHODANESE
(Thermus
thermophilus) 		4 / 8 SER A 247
ALA A 243
ILE A 242
ASN A 264
 None
 0.87A 1pnlA-1uarA:
0.0
1pnlB-1uarA:
undetectable		 1pnlA-1uarA:
21.55
1pnlB-1uarA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 1uar RHODANESE
(Thermus
thermophilus) 		5 / 12 GLY A 178
GLY A 283
ILE A 280
ALA A 281
GLN A 174
 None
 1.03A 1ri4A-1uarA:
undetectable		 1ri4A-1uarA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 1uar RHODANESE
(Thermus
thermophilus) 		3 / 3 ASP A 266
PHE A  61
ARG A 147
 None
 0.88A 2a3aA-1uarA:
undetectable		 2a3aA-1uarA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1uar RHODANESE
(Thermus
thermophilus) 		4 / 5 VAL A  15
THR A  12
GLY A 114
TRP A 118
 None
 1.03A 2p2fA-1uarA:
undetectable		 2p2fA-1uarA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1uar RHODANESE
(Thermus
thermophilus) 		3 / 3 TRP A 250
VAL A 237
TRP A  98
 None
 1.34A 2xdcC-1uarA:
undetectable
2xdcD-1uarA:
undetectable		 2xdcC-1uarA:
4.44
2xdcD-1uarA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1uar RHODANESE
(Thermus
thermophilus) 		3 / 3 TRP A 250
VAL A 237
TRP A  98
 None
 1.33A 2y5mE-1uarA:
undetectable
2y5mF-1uarA:
undetectable		 2y5mE-1uarA:
4.44
2y5mF-1uarA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1uar RHODANESE
(Thermus
thermophilus) 		3 / 3 ASN A 103
HIS A 105
VAL A  82
 None
 0.84A 3elzB-1uarA:
undetectable		 3elzB-1uarA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 1uar RHODANESE
(Thermus
thermophilus) 		4 / 6 ALA A 200
ILE A 197
VAL A 237
HIS A 156
 None
 1.15A 3nneG-1uarA:
undetectable		 3nneG-1uarA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1uar RHODANESE
(Thermus
thermophilus) 		5 / 12 TYR A   3
GLU A 226
GLY A 258
LEU A 253
ALA A 223
 None
 1.07A 3ou6C-1uarA:
undetectable		 3ou6C-1uarA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1uar RHODANESE
(Thermus
thermophilus) 		4 / 4 PHE A 215
THR A 214
LEU A   9
TYR A   3
 None
 1.30A 3pgyB-1uarA:
0.8		 3pgyB-1uarA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 1uar RHODANESE
(Thermus
thermophilus) 		4 / 5 LEU A   9
GLU A   7
LEU A 257
HIS A 248
 None
 1.36A 4xi3B-1uarA:
undetectable		 4xi3B-1uarA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1uar RHODANESE
(Thermus
thermophilus) 		3 / 3 ARG A 115
ASP A  30
TYR A  36
 None
 0.90A 4yo9B-1uarA:
undetectable		 4yo9B-1uarA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1uar RHODANESE
(Thermus
thermophilus) 		3 / 3 ARG A 123
LYS A 117
GLU A 121
 GOL  A1902 (-4.1A)
None
GOL  A1902 (-3.3A)
 0.74A 5d0yA-1uarA:
undetectable		 5d0yA-1uarA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1uar RHODANESE
(Thermus
thermophilus) 		4 / 7 LEU A 110
VAL A   8
GLU A   7
VAL A 108
 None
 1.15A 5jh7C-1uarA:
undetectable		 5jh7C-1uarA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1uar RHODANESE
(Thermus
thermophilus) 		5 / 12 GLU A 121
ASP A 212
GLY A 213
LEU A 110
ALA A  93
 GOL  A1902 (-3.3A)
None
None
None
None
 1.39A 5kbwA-1uarA:
undetectable		 5kbwA-1uarA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1uar RHODANESE
(Thermus
thermophilus) 		5 / 12 ASP A  30
ALA A  96
PHE A 100
THR A  80
LEU A  74
 None
 1.31A 5m54B-1uarA:
undetectable		 5m54B-1uarA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 1uar RHODANESE
(Thermus
thermophilus) 		3 / 3 THR A  80
HIS A 105
ASN A  78
 None
 0.80A 5n4tA-1uarA:
undetectable		 5n4tA-1uarA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1uar RHODANESE
(Thermus
thermophilus) 		5 / 9 ALA A 191
GLY A 190
GLY A 267
ASN A 274
ARG A 193
 None
 1.12A 6nm4B-1uarA:
undetectable		 6nm4B-1uarA:
19.86