SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		4 / 7 GLY A 247
HIS A  18
THR A 257
ILE A 246
 None
 0.98A 1gtnF-1uasA:
undetectable
1gtnG-1uasA:
undetectable		 1gtnF-1uasA:
13.70
1gtnG-1uasA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		5 / 12 LEU A  79
VAL A  83
VAL A 250
LEU A  35
PHE A  19
 None
 1.39A 1mx1E-1uasA:
undetectable		 1mx1E-1uasA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		5 / 12 GLY A  75
PHE A  72
ALA A  78
ASP A  81
ARG A  29
 None
 1.05A 2avdA-1uasA:
undetectable		 2avdA-1uasA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		3 / 3 TRP A 237
GLN A 277
TRP A 334
 None
 1.36A 2vqyA-1uasA:
undetectable		 2vqyA-1uasA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		5 / 10 PHE A 159
TYR A 129
PHE A 119
GLY A 107
PHE A  65
 None
 1.48A 3r6wA-1uasA:
0.0
3r6wB-1uasA:
1.2		 3r6wA-1uasA:
20.66
3r6wB-1uasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		4 / 5 ASP A 198
THR A 194
GLU A 288
LYS A 280
 None
GOL  A1603 (-3.2A)
None
None
 1.20A 4a3pA-1uasA:
0.0		 4a3pA-1uasA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		5 / 10 ILE A 260
LEU A 261
ASP A 188
GLU A 219
GLY A 223
 None
 1.21A 4bwlC-1uasA:
9.4		 4bwlC-1uasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		4 / 7 ASN A 285
LEU A 287
ARG A 306
SER A 308
 None
None
GOL  A1603 (-3.7A)
None
 1.02A 4cp3A-1uasA:
undetectable
4cp3B-1uasA:
undetectable		 4cp3A-1uasA:
16.18
4cp3B-1uasA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		4 / 6 ASP A 130
ASP A  51
ASP A 214
ASN A  14
 GLA  A1501 (-2.5A)
GLA  A1501 (-2.9A)
None
None
 1.34A 4gkhJ-1uasA:
2.1		 4gkhJ-1uasA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		3 / 3 VAL A  36
GLY A  39
LYS A  42
 None
 0.53A 4k50A-1uasA:
undetectable		 4k50A-1uasA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		3 / 3 VAL A  36
GLY A  39
LYS A  42
 None
 0.54A 4k50E-1uasA:
undetectable		 4k50E-1uasA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		3 / 3 VAL A  36
GLY A  39
LYS A  42
 None
 0.57A 4k50I-1uasA:
undetectable		 4k50I-1uasA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		3 / 3 ASP A 130
TYR A  93
TRP A 164
 GLA  A1501 (-2.5A)
GLA  A1501 (-4.4A)
GLA  A1501 (-4.1A)
 1.02A 4p7nA-1uasA:
10.8		 4p7nA-1uasA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		3 / 3 SER A 160
TYR A 126
ASP A 216
 None
None
GLA  A1501 ( 4.4A)
 0.75A 4rp8C-1uasA:
undetectable		 4rp8C-1uasA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		5 / 12 ILE A  92
ILE A  76
ASN A  24
LEU A  79
THR A  31
 None
 1.00A 5uvmB-1uasA:
2.4		 5uvmB-1uasA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		4 / 6 GLN A 271
VAL A 269
PRO A   9
ALA A 300
 GOL  A1607 (-4.1A)
None
None
None
 0.92A 6cduB-1uasA:
0.0
6cduC-1uasA:
0.0		 6cduB-1uasA:
20.32
6cduC-1uasA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		4 / 7 GLN A 271
VAL A 269
PRO A   9
ALA A 300
 GOL  A1607 (-4.1A)
None
None
None
 0.96A 6cduC-1uasA:
undetectable
6cduD-1uasA:
undetectable		 6cduC-1uasA:
20.32
6cduD-1uasA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1uas ALPHA-GALACTOSIDASE
(Oryza
sativa) 		4 / 7 ASP A 201
GLY A 292
GLY A 278
VAL A 276
 None
 0.91A 6ekzA-1uasA:
0.0		 6ekzA-1uasA:
13.02