SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		4 / 7 ALA A   4
ILE A 140
ILE A  30
ASP A  26
 None
 0.94A 1upfB-1uaxA:
undetectable		 1upfB-1uaxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		4 / 5 VAL A 150
THR A 151
VAL A  65
GLY A  21
 None
 0.74A 2p2fA-1uaxA:
undetectable		 2p2fA-1uaxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		4 / 4 VAL A 150
THR A 151
VAL A  65
GLY A  21
 None
 0.77A 2p2fB-1uaxA:
undetectable		 2p2fB-1uaxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		4 / 6 ILE A  20
PRO A  99
LEU A 122
ILE A 102
 None
 1.03A 2q83B-1uaxA:
undetectable		 2q83B-1uaxA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		5 / 9 ALA A  91
ALA A  23
GLY A   5
GLY A  21
ILE A 147
 None
 1.26A 2v7bA-1uaxA:
undetectable		 2v7bA-1uaxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		5 / 9 ALA A  91
ALA A  23
GLY A   5
GLY A  21
ILE A 147
 None
 1.25A 2v7bB-1uaxA:
undetectable		 2v7bB-1uaxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		5 / 12 VAL A   6
VAL A  24
TYR A  64
GLY A   5
PHE A  88
 None
 1.20A 3mecA-1uaxA:
3.8		 3mecA-1uaxA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		4 / 8 GLY A   5
LYS A 101
TYR A 103
GLU A  27
 None
 0.91A 4hyfB-1uaxA:
undetectable		 4hyfB-1uaxA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		3 / 3 ARG A 195
TRP A 198
ILE A  73
 None
 1.11A 4mwxA-1uaxA:
undetectable		 4mwxA-1uaxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		4 / 6 LEU A  92
LYS A  98
PRO A  99
TYR A 124
 None
 1.20A 4z4gA-1uaxA:
6.8		 4z4gA-1uaxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		4 / 5 SER A 172
ARG A  11
GLY A  10
GLU A   8
 None
 1.09A 5btiA-1uaxA:
undetectable
5btiB-1uaxA:
undetectable		 5btiA-1uaxA:
20.00
5btiB-1uaxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		4 / 5 SER A 172
ARG A  11
GLY A  10
GLU A   8
 None
 1.19A 5btiC-1uaxA:
undetectable
5btiD-1uaxA:
undetectable		 5btiC-1uaxA:
20.00
5btiD-1uaxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 1uax RIBONUCLEASE HII
(Pyrococcus
horikoshii) 		4 / 7 GLY A  10
ALA A   9
VAL A  65
LEU A  67
 None
 0.81A 6dwnB-1uaxA:
undetectable		 6dwnB-1uaxA:
14.35