SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ARG A 232
ALA A 177
ALA A 137
GLU A 140
 None
 0.98A 1e7bA-1uayA:
undetectable		 1e7bA-1uayA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PHE A 181
GLY A  13
SER A  12
ALA A 214
ALA A  18
 None
None
ADN  A1001 (-2.9A)
None
None
 1.09A 1nw5A-1uayA:
2.4		 1nw5A-1uayA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A  33
ARG A  35
ASP A  47
 ADN  A1001 (-2.9A)
ADN  A1001 (-3.7A)
ADN  A1001 (-2.9A)
 0.95A 1vptA-1uayA:
4.7		 1vptA-1uayA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A   9
ALA A  11
ALA A  17
LEU A  34
VAL A  48
 ADN  A1001 (-3.5A)
ADN  A1001 ( 3.7A)
None
ADN  A1001 (-4.3A)
ADN  A1001 (-3.6A)
 0.97A 2nyuA-1uayA:
9.1		 2nyuA-1uayA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A   9
ALA A  11
LEU A  34
VAL A  48
THR A  49
 ADN  A1001 (-3.5A)
ADN  A1001 ( 3.7A)
ADN  A1001 (-4.3A)
ADN  A1001 (-3.6A)
ADN  A1001 ( 4.5A)
 0.71A 2nyuB-1uayA:
9.1		 2nyuB-1uayA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 216
ALA A  17
LEU A  14
ALA A  73
 None
 0.78A 2vcvP-1uayA:
undetectable		 2vcvP-1uayA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 LEU A 233
SER A 135
THR A 133
VAL A  71
 None
 0.85A 3d2tA-1uayA:
undetectable		 3d2tA-1uayA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A   9
ALA A  17
ASP A  47
VAL A  48
VAL A 100
 ADN  A1001 (-3.5A)
None
ADN  A1001 (-2.9A)
ADN  A1001 (-3.6A)
ADN  A1001 ( 4.4A)
 1.01A 3dmfA-1uayA:
6.5		 3dmfA-1uayA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  10
GLY A  13
SER A  72
GLU A  39
ALA A  19
 None
 1.24A 3sxjA-1uayA:
4.2		 3sxjA-1uayA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  10
GLY A  13
SER A  72
GLU A  39
ALA A  19
 None
 1.25A 3sxjB-1uayA:
5.1		 3sxjB-1uayA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  10
GLY A  13
SER A  72
GLU A  39
ALA A  19
 None
 1.35A 3t7sD-1uayA:
4.5		 3t7sD-1uayA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A  18
LEU A  20
GLY A  10
ALA A  57
LEU A  67
 None
 1.34A 3tm4A-1uayA:
undetectable		 3tm4A-1uayA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ASP A  47
GLY A 104
VAL A 100
THR A   8
 ADN  A1001 (-2.9A)
None
ADN  A1001 ( 4.4A)
None
 1.10A 3vqrA-1uayA:
3.6		 3vqrA-1uayA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 ASP A  47
GLY A 104
VAL A 100
THR A   8
 ADN  A1001 (-2.9A)
None
ADN  A1001 ( 4.4A)
None
 1.11A 3vqrB-1uayA:
5.3		 3vqrB-1uayA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ALA A 177
GLN A 145
GLY A 144
 None
 0.48A 4odoC-1uayA:
undetectable		 4odoC-1uayA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 GLY A   9
GLY A  10
ASP A  33
LEU A  34
ASP A  47
 ADN  A1001 (-3.5A)
None
ADN  A1001 (-2.9A)
ADN  A1001 (-4.3A)
ADN  A1001 (-2.9A)
 0.54A 4pghA-1uayA:
5.4		 4pghA-1uayA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 122
ARG A 172
PRO A 224
 None
 0.81A 4wanC-1uayA:
undetectable		 4wanC-1uayA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A   9
ASP A  33
LEU A  34
VAL A  76
VAL A 100
 ADN  A1001 (-3.5A)
ADN  A1001 (-2.9A)
ADN  A1001 (-4.3A)
None
ADN  A1001 ( 4.4A)
 0.92A 5dpdB-1uayA:
4.4		 5dpdB-1uayA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  75
VAL A 100
ASP A  33
GLN A 187
GLY A  77
 ADN  A1001 (-4.1A)
ADN  A1001 ( 4.4A)
ADN  A1001 (-2.9A)
None
None
 1.07A 6gneA-1uayA:
5.1		 6gneA-1uayA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  75
VAL A 100
ASP A  33
GLN A 187
GLY A  77
 ADN  A1001 (-4.1A)
ADN  A1001 ( 4.4A)
ADN  A1001 (-2.9A)
None
None
 1.08A 6gneB-1uayA:
5.1		 6gneB-1uayA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 GLY A 141
GLY A 179
SER A 135
ALA A 134
 None
 0.80A 6hu9H-1uayA:
undetectable
6hu9e-1uayA:
undetectable		 6hu9H-1uayA:
16.45
6hu9e-1uayA:
18.70