SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uaz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		3 / 3 ILE A 209
LEU A 212
VAL A 216
 None
 0.47A 1mz9B-1uazA:
undetectable		 1mz9B-1uazA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		3 / 3 THR A 179
LEU A 183
VAL A 186
 None
 0.49A 1mz9E-1uazA:
undetectable		 1mz9E-1uazA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 12 ALA A 132
ILE A 196
ILE A 197
THR A 199
LEU A  82
 None
 1.31A 2bjfA-1uazA:
undetectable		 2bjfA-1uazA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		4 / 8 SER A 113
ALA A 166
ARG A 169
LEU A 106
 None
 1.14A 2bxkA-1uazA:
2.6		 2bxkA-1uazA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 11 GLY A 131
ALA A 132
GLY A 201
ILE A 196
PHE A 214
 None
 0.88A 2fxdA-1uazA:
undetectable		 2fxdA-1uazA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		4 / 7 VAL A 126
VAL A 130
LEU A 133
SER A 134
 None
 0.86A 3hs6B-1uazA:
undetectable		 3hs6B-1uazA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		4 / 8 ASP A 218
TYR A 191
LEU A  98
PRO A  97
 RET  A 255 (-4.4A)
RET  A 255 (-3.7A)
None
None
 1.25A 3jq7B-1uazA:
undetectable		 3jq7B-1uazA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		3 / 3 ALA A 159
ARG A 163
LYS A 167
 None
 0.86A 3kp3B-1uazA:
0.0		 3kp3B-1uazA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		3 / 3 LYS A 108
ARG A 169
ASP A  42
 None
 1.03A 3o7wA-1uazA:
undetectable		 3o7wA-1uazA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		4 / 6 ASP A  11
ALA A   6
LEU A   8
THR A  16
 None
 1.07A 3rozA-1uazA:
undetectable		 3rozA-1uazA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		3 / 3 LEU A 103
VAL A 118
ASP A 121
 None
 0.62A 4y8wC-1uazA:
0.0		 4y8wC-1uazA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 12 LEU A 229
LEU A  99
LEU A 103
LEU A 158
LEU A 187
 None
 1.23A 5toaB-1uazA:
undetectable		 5toaB-1uazA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 11 ALA A 166
TYR A  48
LEU A 229
ALA A 107
LEU A 162
 None
 1.41A 6dk1B-1uazA:
0.0		 6dk1B-1uazA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_A_HSMA401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 9 TYR A 191
GLU A 210
GLU A 200
TYR A  89
ASP A 218
 RET  A 255 (-3.7A)
None
None
None
RET  A 255 (-4.4A)
 1.35A 6fu4A-1uazA:
0.0		 6fu4A-1uazA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_B_HSMB401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 9 TYR A 191
GLU A 210
GLU A 200
TYR A  89
ASP A 218
 RET  A 255 (-3.7A)
None
None
None
RET  A 255 (-4.4A)
 1.38A 6fu4B-1uazA:
0.0		 6fu4B-1uazA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_C_HSMC401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 9 TYR A 191
GLU A 210
GLU A 200
TYR A  89
ASP A 218
 RET  A 255 (-3.7A)
None
None
None
RET  A 255 (-4.4A)
 1.38A 6fu4C-1uazA:
0.0		 6fu4C-1uazA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_D_HSMD401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 9 TYR A 191
GLU A 210
GLU A 200
TYR A  89
ASP A 218
 RET  A 255 (-3.7A)
None
None
None
RET  A 255 (-4.4A)
 1.40A 6fu4D-1uazA:
0.0		 6fu4D-1uazA:
16.38