SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ub0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 10 ALA A 159
LEU A 163
PRO A 167
ALA A 187
GLY A 191
 None
 1.23A 1mjqG-1ub0A:
undetectable
1mjqH-1ub0A:
undetectable		 1mjqG-1ub0A:
15.29
1mjqH-1ub0A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 8 THR A 135
PRO A 136
VAL A 170
ALA A 131
PRO A 104
 None
 1.44A 2v32A-1ub0A:
undetectable
2v32B-1ub0A:
undetectable		 2v32A-1ub0A:
24.10
2v32B-1ub0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 8 PRO A 104
THR A 135
PRO A 136
VAL A 170
ALA A 131
 None
 1.40A 2v32A-1ub0A:
undetectable
2v32B-1ub0A:
undetectable		 2v32A-1ub0A:
24.10
2v32B-1ub0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 9 THR A 135
PRO A 136
VAL A 170
ALA A 131
PRO A 104
 None
 1.43A 2v41A-1ub0A:
undetectable
2v41B-1ub0A:
undetectable		 2v41A-1ub0A:
24.10
2v41B-1ub0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 9 PRO A 104
THR A 135
PRO A 136
VAL A 170
ALA A 131
 None
 1.42A 2v41A-1ub0A:
undetectable
2v41B-1ub0A:
undetectable		 2v41A-1ub0A:
24.10
2v41B-1ub0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		4 / 5 LEU A 241
THR A 202
THR A 211
HIS A 256
 None
 1.34A 2zj0C-1ub0A:
2.7		 2zj0C-1ub0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		4 / 5 LEU A 241
THR A 202
THR A 211
HIS A 256
 None
 1.37A 3ce6B-1ub0A:
2.4		 3ce6B-1ub0A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 11 ALA A 214
ALA A 217
VAL A  24
ALA A  16
GLY A  17
 None
 0.94A 3mg0K-1ub0A:
undetectable
3mg0L-1ub0A:
undetectable		 3mg0K-1ub0A:
25.09
3mg0L-1ub0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		4 / 4 GLY A 209
GLY A 207
THR A 205
LEU A 241
 None
 0.95A 3si7C-1ub0A:
undetectable
3si7D-1ub0A:
undetectable		 3si7C-1ub0A:
21.38
3si7D-1ub0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		4 / 6 CYH A 210
THR A 211
GLY A  17
ASP A  21
 None
 1.14A 3w9tE-1ub0A:
undetectable		 3w9tE-1ub0A:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		7 / 11 GLY A   9
ASP A  11
ALA A  16
GLY A  17
VAL A 105
HIS A 206
CYH A 210
 None
 0.42A 4c5lA-1ub0A:
33.6		 4c5lA-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		7 / 9 GLY A   9
ASP A  11
ALA A  16
GLY A  17
VAL A 105
HIS A 206
CYH A 210
 None
 0.42A 4c5lB-1ub0A:
33.5		 4c5lB-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		7 / 10 GLY A   9
ASP A  11
ALA A  16
GLY A  17
VAL A 105
HIS A 206
CYH A 210
 None
 0.45A 4c5lC-1ub0A:
33.6		 4c5lC-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 10 ALA A  16
VAL A  47
VAL A 105
HIS A 206
CYH A 210
 None
GOL  A 301 ( 4.5A)
None
None
None
 1.28A 4c5lD-1ub0A:
33.4		 4c5lD-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		7 / 10 GLY A   9
ASP A  11
ALA A  16
GLY A  17
VAL A 105
HIS A 206
CYH A 210
 None
 0.44A 4c5lD-1ub0A:
33.4		 4c5lD-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 7 GLY A   9
ASP A  11
GLY A  17
HIS A 206
CYH A 210
 None
 0.39A 4c5nA-1ub0A:
34.0		 4c5nA-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 10 ALA A  16
VAL A  47
VAL A 105
HIS A 206
CYH A 210
 None
GOL  A 301 ( 4.5A)
None
None
None
 1.24A 4c5nB-1ub0A:
34.1		 4c5nB-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		7 / 10 GLY A   9
ASP A  11
ALA A  16
GLY A  17
VAL A 105
HIS A 206
CYH A 210
 None
 0.37A 4c5nB-1ub0A:
34.1		 4c5nB-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		6 / 8 GLY A   9
ASP A  11
GLY A  17
VAL A 105
HIS A 206
CYH A 210
 None
 0.44A 4c5nC-1ub0A:
34.0		 4c5nC-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 10 ALA A  16
VAL A  47
VAL A 105
HIS A 206
CYH A 210
 None
GOL  A 301 ( 4.5A)
None
None
None
 1.23A 4c5nD-1ub0A:
34.0		 4c5nD-1ub0A:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		7 / 10 GLY A   9
ASP A  11
ALA A  16
GLY A  17
VAL A 105
HIS A 206
CYH A 210
 None
 0.42A 4c5nD-1ub0A:
34.0		 4c5nD-1ub0A:
36.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  74
LEU A   5
ALA A   4
ILE A  84
LEU A 127
 None
 1.04A 4nqaH-1ub0A:
undetectable		 4nqaH-1ub0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		5 / 8 ALA A 141
GLY A 175
LEU A 172
LEU A 162
GLU A 154
 None
 1.20A 4po0A-1ub0A:
2.0		 4po0A-1ub0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		4 / 5 ASP A  11
VAL A 105
ASP A 103
GLY A 209
 None
 0.97A 4xp6A-1ub0A:
0.0		 4xp6A-1ub0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE
(Thermus
thermophilus) 		3 / 3 LYS A 173
LEU A 133
ASP A 103
 None
 0.95A 5zv2A-1ub0A:
undetectable		 5zv2A-1ub0A:
13.10