SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ub3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 4 ARG A 176
ALA A 177
ALA A 139
GLU A 140
 None
 1.07A 1e7bA-1ub3A:
undetectable		 1e7bA-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 4 ARG A 176
ALA A 177
ALA A 142
GLU A 140
 None
 1.15A 1e7bA-1ub3A:
undetectable		 1e7bA-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 4 ARG A 176
ALA A 177
ALA A 139
GLU A 140
 None
 1.13A 1e7bB-1ub3A:
undetectable		 1e7bB-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 4 ARG A 176
ALA A 177
ALA A 142
GLU A 140
 None
 1.15A 1e7bB-1ub3A:
undetectable		 1e7bB-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 5 ARG A 176
ALA A 177
ALA A 139
GLU A 140
 None
 1.10A 1e7cA-1ub3A:
undetectable		 1e7cA-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 5 ARG A 176
ALA A 177
ALA A 142
GLU A 140
 None
 1.12A 1e7cA-1ub3A:
undetectable		 1e7cA-1ub3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 7 MET A 194
SER A 153
ALA A 182
ILE A 185
 None
None
HPD  A 801 (-3.2A)
None
 0.94A 1fxhA-1ub3A:
undetectable
1fxhB-1ub3A:
undetectable		 1fxhA-1ub3A:
21.72
1fxhB-1ub3A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 8 MET A 194
SER A 153
ALA A 182
ILE A 185
 None
None
HPD  A 801 (-3.2A)
None
 0.83A 1gm7A-1ub3A:
undetectable
1gm7B-1ub3A:
undetectable		 1gm7A-1ub3A:
21.72
1gm7B-1ub3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 8 GLY A 207
ALA A 191
THR A 204
ILE A   7
 None
None
HPD  A 801 (-4.4A)
None
 0.83A 1gtnP-1ub3A:
undetectable
1gtnQ-1ub3A:
undetectable		 1gtnP-1ub3A:
18.43
1gtnQ-1ub3A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 7 ALA A 119
GLU A  87
LEU A 121
VAL A 112
 None
 0.72A 1hk2A-1ub3A:
undetectable		 1hk2A-1ub3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A 169
ASP A 165
GLY A 160
ARG A 159
 None
 0.87A 1mt1G-1ub3A:
undetectable
1mt1J-1ub3A:
undetectable		 1mt1G-1ub3A:
14.08
1mt1J-1ub3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 7 ARG A 159
LEU A 169
ASP A 165
GLY A 160
 None
 0.88A 1mt1H-1ub3A:
undetectable
1mt1K-1ub3A:
undetectable		 1mt1H-1ub3A:
18.67
1mt1K-1ub3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A 159
LEU A 169
ASP A 165
GLY A 160
 None
 0.92A 1n13H-1ub3A:
undetectable
1n13K-1ub3A:
undetectable		 1n13H-1ub3A:
18.67
1n13K-1ub3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A 169
ASP A 165
GLY A 160
ARG A 159
 None
 0.92A 1n13G-1ub3A:
undetectable
1n13J-1ub3A:
undetectable		 1n13G-1ub3A:
14.08
1n13J-1ub3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 8 MET A 194
SER A 153
ALA A 182
ILE A 185
 None
None
HPD  A 801 (-3.2A)
None
 0.88A 1pnlA-1ub3A:
undetectable
1pnlB-1ub3A:
0.0		 1pnlA-1ub3A:
21.72
1pnlB-1ub3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 7 ILE A   7
ARG A 201
ASP A  89
GLU A  87
 None
None
HPD  A 801 ( 4.6A)
None
 1.01A 2qebB-1ub3A:
undetectable		 2qebB-1ub3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 8 ARG A 159
LEU A 169
ASP A 165
GLY A 160
 None
 0.85A 2qqcH-1ub3A:
undetectable
2qqcK-1ub3A:
undetectable		 2qqcH-1ub3A:
19.18
2qqcK-1ub3A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 8 ARG A 159
LEU A 169
ASP A 165
GLY A 160
 None
 0.90A 2qqdB-1ub3A:
undetectable
2qqdC-1ub3A:
undetectable		 2qqdB-1ub3A:
19.18
2qqdC-1ub3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 141
GLU A 140
LEU A 125
ARG A 176
LEU A  92
 None
 1.28A 3erdB-1ub3A:
undetectable		 3erdB-1ub3A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 6 GLU A  27
PHE A  33
THR A 204
ALA A  24
 None
None
HPD  A 801 (-4.4A)
None
 1.22A 3ns1C-1ub3A:
undetectable		 3ns1C-1ub3A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 182
GLY A 184
SER A 205
ASP A   8
SER A 153
 HPD  A 801 (-3.2A)
HPD  A 801 (-3.9A)
HPD  A 801 (-2.6A)
None
None
 1.19A 3pfgA-1ub3A:
3.1		 3pfgA-1ub3A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 128
ASP A 165
GLY A 155
SER A 153
ALA A 181
 None
None
HPD  A 801 (-3.6A)
None
None
 1.14A 3sueB-1ub3A:
undetectable		 3sueB-1ub3A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 128
ASP A 165
GLY A 155
SER A 153
ALA A 181
 None
None
HPD  A 801 (-3.6A)
None
None
 1.21A 3sueD-1ub3A:
undetectable		 3sueD-1ub3A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 6 GLU A 126
GLY A 128
LEU A  94
GLU A 134
 None
 1.16A 3w9tE-1ub3A:
undetectable		 3w9tE-1ub3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 6 GLU A 126
GLY A 128
LEU A  94
GLU A 134
 None
 1.16A 3w9tF-1ub3A:
undetectable		 3w9tF-1ub3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 105
GLU A 108
LEU A  94
ILE A 135
LEU A 150
 None
 1.30A 4j24C-1ub3A:
undetectable		 4j24C-1ub3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 105
GLU A 108
LEU A  94
ILE A 135
LEU A 150
 None
 1.30A 4j26B-1ub3A:
undetectable		 4j26B-1ub3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A  89
VAL A 120
SER A 200
ALA A 182
 HPD  A 801 ( 4.6A)
None
None
HPD  A 801 (-3.2A)
 1.24A 4nedA-1ub3A:
undetectable		 4nedA-1ub3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		3 / 3 TRP A  45
ARG A  49
LEU A  36
 None
 0.77A 5dbyA-1ub3A:
undetectable		 5dbyA-1ub3A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		5 / 11 LEU A 202
GLY A 183
SER A 200
LEU A 195
ALA A 191
 None
HPD  A 801 (-3.4A)
None
None
None
 1.08A 5o96A-1ub3A:
2.2
5o96B-1ub3A:
2.2		 5o96A-1ub3A:
23.39
5o96B-1ub3A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 1ub3 ALDOLASE PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 125
LEU A 169
LEU A  92
ALA A 177
LEU A 121
 None
 1.05A 5og9B-1ub3A:
0.0		 5og9B-1ub3A:
19.96