SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ub7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		4 / 8 ASP A 145
ASP A 148
TYR A  24
THR A 151
 None
 1.45A 1ceaA-1ub7A:
undetectable
1ceaB-1ub7A:
undetectable		 1ceaA-1ub7A:
11.67
1ceaB-1ub7A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		6 / 12 LEU A 250
ASN A 249
GLN A 247
VAL A 267
ALA A 255
PHE A 215
 None
 1.12A 1gs4A-1ub7A:
undetectable		 1gs4A-1ub7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 TYR A 104
PHE A 102
LEU A 117
VAL A 164
ALA A  74
 None
 1.23A 1gseA-1ub7A:
undetectable		 1gseA-1ub7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ILE A 252
ASN A 276
GLY A 211
PHE A 215
ALA A 308
 None
CSO  A 110 ( 4.4A)
None
None
CSO  A 110 ( 4.4A)
 1.23A 1hvyA-1ub7A:
undetectable		 1hvyA-1ub7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ILE A 252
ASN A 276
GLY A 211
PHE A 215
ALA A 308
 None
CSO  A 110 ( 4.4A)
None
None
CSO  A 110 ( 4.4A)
 1.22A 1hvyB-1ub7A:
undetectable		 1hvyB-1ub7A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 11 ILE A 252
ASN A 276
GLY A 211
PHE A 215
ALA A 308
 None
CSO  A 110 ( 4.4A)
None
None
CSO  A 110 ( 4.4A)
 1.24A 1ju6A-1ub7A:
undetectable		 1ju6A-1ub7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 10 ILE A 252
ASN A 276
GLY A 211
PHE A 215
ALA A 308
 None
CSO  A 110 ( 4.4A)
None
None
CSO  A 110 ( 4.4A)
 1.24A 1ju6C-1ub7A:
undetectable		 1ju6C-1ub7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 10 LEU A 117
LEU A   5
VAL A 132
GLY A 165
SER A   2
 None
 1.12A 1pxxA-1ub7A:
undetectable		 1pxxA-1ub7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 9 LEU A 117
LEU A   5
VAL A 132
GLY A 165
SER A   2
 None
 1.10A 1pxxB-1ub7A:
undetectable		 1pxxB-1ub7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A 117
LEU A   5
VAL A 132
GLY A 165
SER A   2
 None
 1.10A 1pxxC-1ub7A:
undetectable		 1pxxC-1ub7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 10 LEU A 117
LEU A   5
VAL A 132
GLY A 165
SER A   2
 None
 1.11A 1pxxD-1ub7A:
undetectable		 1pxxD-1ub7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		3 / 3 VAL A 219
ALA A 218
HIS A 246
 None
None
CSO  A 110 ( 3.9A)
 0.70A 1q23C-1ub7A:
undetectable		 1q23C-1ub7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		3 / 3 VAL A 219
ALA A 218
HIS A 246
 None
None
CSO  A 110 ( 3.9A)
 0.60A 1q23H-1ub7A:
undetectable		 1q23H-1ub7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		3 / 3 VAL A 219
ALA A 218
HIS A 246
 None
None
CSO  A 110 ( 3.9A)
 0.62A 1q23G-1ub7A:
undetectable		 1q23G-1ub7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		3 / 3 VAL A 219
ALA A 218
HIS A 246
 None
None
CSO  A 110 ( 3.9A)
 0.58A 1q23J-1ub7A:
undetectable		 1q23J-1ub7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		4 / 8 VAL A 163
VAL A  72
LEU A   5
ASP A  73
 None
 1.08A 2ddwA-1ub7A:
undetectable		 2ddwA-1ub7A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A 250
ASN A 249
GLN A 247
ALA A 255
PHE A 215
 None
 0.99A 2oz7A-1ub7A:
undetectable		 2oz7A-1ub7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 9 VAL A 290
ILE A 295
LEU A   5
GLY A 321
ALA A 322
 None
 1.27A 2xf3B-1ub7A:
0.0		 2xf3B-1ub7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 9 VAL A 290
ILE A 295
LEU A   5
GLY A 321
ALA A 322
 None
 1.27A 2xfsB-1ub7A:
0.1		 2xfsB-1ub7A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 9 VAL A 290
ILE A 295
LEU A   5
GLY A 321
ALA A 322
 None
 1.27A 2xh9B-1ub7A:
0.0		 2xh9B-1ub7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LYS A 186
LEU A 188
ASN A 210
MET A 209
ALA A 218
 None
 1.27A 4x1iB-1ub7A:
undetectable		 4x1iB-1ub7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 8 ALA A 161
VAL A  58
GLY A 136
ALA A 280
GLY A 159
 None
 1.35A 4zjzB-1ub7A:
undetectable		 4zjzB-1ub7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		4 / 4 LEU A 117
ILE A 114
PRO A 283
LEU A 286
 None
 0.92A 5eb3A-1ub7A:
undetectable		 5eb3A-1ub7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 10 ALA A  57
ALA A  54
VAL A  77
LEU A  69
VAL A  75
 None
 1.50A 5eb5B-1ub7A:
undetectable		 5eb5B-1ub7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 VAL A 124
GLU A 125
ALA A 120
GLY A 172
LEU A 317
 None
 1.20A 5m5cB-1ub7A:
undetectable		 5m5cB-1ub7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 10 VAL A 124
GLU A 125
ALA A 120
GLY A 172
LEU A 317
 None
 1.23A 5m5cE-1ub7A:
undetectable		 5m5cE-1ub7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A  44
PHE A 306
ALA A 218
THR A  36
LEU A 154
 None
 1.26A 5tl8A-1ub7A:
undetectable		 5tl8A-1ub7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		4 / 7 ASN A  80
ILE A  76
LEU A 106
LEU A 107
 CSO  A 110 ( 4.5A)
None
None
None
 0.89A 5u4sA-1ub7A:
undetectable		 5u4sA-1ub7A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		4 / 7 GLU A  59
PHE A  97
ALA A 161
GLY A   8
 None
 0.96A 5uxdA-1ub7A:
undetectable		 5uxdA-1ub7A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 10 SER A   2
GLY A 165
ILE A  76
ALA A 134
PHE A 217
 None
 1.18A 5zjiA-1ub7A:
undetectable
5zjiJ-1ub7A:
undetectable		 5zjiA-1ub7A:
15.25
5zjiJ-1ub7A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A   6
LEU A 133
ALA A  68
HIS A 121
LEU A 117
 None
None
None
GOL  A 402 ( 4.6A)
None
 1.03A 6a60D-1ub7A:
undetectable		 6a60D-1ub7A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A  44
PHE A 306
ALA A 218
THR A  36
LEU A 154
 None
 1.25A 6aycA-1ub7A:
undetectable		 6aycA-1ub7A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE
(Thermus
thermophilus) 		5 / 12 VAL A 219
GLY A 112
ALA A 314
ALA A 315
VAL A 316
 None
CSO  A 110 ( 4.2A)
None
None
None
 0.93A 6c2mC-1ub7A:
undetectable		 6c2mC-1ub7A:
12.50