SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 TYR A 226
GLY A 235
LEU B 148
VAL B 113
 None
CNC  B2601 ( 3.7A)
CNC  B2601 (-4.1A)
CNC  B2601 (-4.9A)
 1.02A 1gsfC-1uc4A:
undetectable		 1gsfC-1uc4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 11 GLY B  68
PRO B  69
HIS B  84
GLN B 133
LEU B 160
 None
None
None
CNC  B2601 ( 4.7A)
None
 1.06A 1jzsA-1uc4B:
undetectable		 1jzsA-1uc4B:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ILE B 130
ALA B 117
LEU B 153
LEU B 160
ILE B 132
 None
None
CNC  B2601 (-4.0A)
None
None
 1.03A 1rd7B-1uc4B:
undetectable		 1rd7B-1uc4B:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 PRO A 138
ASP A 358
ASP A 520
 None
 0.73A 1sqfA-1uc4A:
2.1		 1sqfA-1uc4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 LEU B 203
ALA B 157
GLY B  81
HIS B  84
 None
CNC  B2601 (-3.2A)
None
None
 0.71A 1sv9A-1uc4B:
undetectable		 1sv9A-1uc4B:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 MET A 129
ASN A 334
GLN A 140
 None
 0.90A 1xoqB-1uc4A:
undetectable		 1xoqB-1uc4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 7 LEU A 515
GLY A 399
VAL A 509
ILE A 507
 None
 0.73A 2aojB-1uc4A:
undetectable		 2aojB-1uc4A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ALA A 158
ALA A 142
ALA A 156
GLY A 193
GLY A 189
 None
 0.94A 2igtA-1uc4A:
undetectable		 2igtA-1uc4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ALA A 158
ALA A 142
ALA A 156
GLY A 193
GLY A 189
 None
 0.90A 2igtB-1uc4A:
undetectable		 2igtB-1uc4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 ARG A 177
VAL A 147
THR B 186
 None
 0.86A 2nnkA-1uc4A:
undetectable		 2nnkA-1uc4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		6 / 12 LEU B 151
ALA B 172
ILE B 168
VAL B  91
ILE B  64
ILE B 140
 None
 1.40A 2rkgA-1uc4B:
undetectable		 2rkgA-1uc4B:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A600_1
(ORF12)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 10 SER A 377
ALA A 142
GLY A 363
SER A 361
PHE A 166
 None
None
PGO  A2602 ( 4.2A)
None
None
 1.39A 2xfsA-1uc4A:
0.0		 2xfsA-1uc4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 7 SER A 377
GLN A 352
ILE A 303
SER A 361
 None
 1.12A 2xz5A-1uc4A:
0.0
2xz5B-1uc4A:
0.0		 2xz5A-1uc4A:
16.93
2xz5B-1uc4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 SER A 377
GLN A 352
ILE A 303
SER A 361
 None
 1.11A 2xz5B-1uc4A:
undetectable
2xz5E-1uc4A:
undetectable		 2xz5B-1uc4A:
16.93
2xz5E-1uc4A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 VAL A 266
PHE A 338
SER A 341
PHE A  19
VAL A 309
 None
 1.43A 2y01A-1uc4A:
undetectable		 2y01A-1uc4A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 ARG A 314
MET A 276
GLU A  25
GLU A  22
 None
 1.20A 3dh0A-1uc4A:
undetectable		 3dh0A-1uc4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 11 LEU A  51
ALA A  76
ILE A 113
PRO A  39
ILE A  41
 None
 1.11A 3ebzA-1uc4A:
undetectable		 3ebzA-1uc4A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 10 GLY B 131
GLN B 133
VAL B 113
ILE B 168
VAL B  91
 None
CNC  B2601 ( 4.7A)
CNC  B2601 (-4.9A)
None
None
 1.23A 3fhjA-1uc4B:
undetectable		 3fhjA-1uc4B:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 5 GLN A 169
THR A 199
THR A 222
HIS A 143
 None
None
NH4  A2605 (-4.2A)
PGO  A2602 (-4.0A)
 1.13A 3g1uC-1uc4A:
undetectable		 3g1uC-1uc4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ILE A 492
GLY A 193
ALA A 159
SER A 190
LEU A 186
 None
 0.92A 3hs6B-1uc4A:
undetectable		 3hs6B-1uc4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ILE A 431
VAL A 188
MET A 426
VAL A 473
VAL A 422
 None
 1.21A 3iw1A-1uc4A:
undetectable		 3iw1A-1uc4A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 11 SER A 377
LEU A 350
PHE A 353
ILE A 390
ASP A 342
 None
 1.38A 3ko0A-1uc4A:
undetectable
3ko0B-1uc4A:
0.0
3ko0C-1uc4A:
undetectable
3ko0D-1uc4A:
undetectable		 3ko0A-1uc4A:
9.76
3ko0B-1uc4A:
9.76
3ko0C-1uc4A:
9.76
3ko0D-1uc4A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 11 LEU A 350
PHE A 353
ILE A 390
ASP A 342
SER A 377
 None
 1.30A 3ko0O-1uc4A:
undetectable
3ko0P-1uc4A:
undetectable
3ko0Q-1uc4A:
0.0
3ko0R-1uc4A:
0.0		 3ko0O-1uc4A:
9.76
3ko0P-1uc4A:
9.76
3ko0Q-1uc4A:
9.76
3ko0R-1uc4A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 8 ASN A 182
THR A 171
GLN A 169
ALA A 158
SER A 190
 None
 1.47A 3kp6A-1uc4A:
1.1		 3kp6A-1uc4A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 ARG A 177
VAL A 147
THR B 186
 None
 0.87A 3nduD-1uc4A:
undetectable		 3nduD-1uc4A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 7 ALA A 418
VAL A 473
VAL A 422
LEU A 419
 None
 0.84A 3o14A-1uc4A:
undetectable		 3o14A-1uc4A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 TYR A 370
ASP A 380
ASP A 386
 None
 0.93A 3ou6B-1uc4A:
undetectable		 3ou6B-1uc4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		6 / 12 GLY B 120
VAL B 113
ILE B 100
GLY B 125
ALA B 172
ALA B 173
 None
CNC  B2601 (-4.9A)
None
None
None
None
 1.42A 3sufD-1uc4B:
undetectable		 3sufD-1uc4B:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 PRO A 239
ILE A 286
ILE A  62
ASP A  60
 None
 0.88A 4dtaB-1uc4A:
undetectable		 4dtaB-1uc4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 6 GLY A 298
GLN A 352
ILE A 303
VAL A 300
 None
 1.17A 4e1vF-1uc4A:
undetectable		 4e1vF-1uc4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 6 SER A 139
ASP A 358
ARG A 257
GLU A 168
 None
 1.11A 4eysA-1uc4A:
undetectable		 4eysA-1uc4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 ASN A 182
ALA A 179
LEU A 211
LEU A 203
 None
 0.92A 4jjkA-1uc4A:
1.4		 4jjkA-1uc4A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 6 GLY B 127
ILE B 128
GLN B 142
SER B 129
 None
 1.02A 4kcnA-1uc4B:
undetectable		 4kcnA-1uc4B:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 GLU A 329
GLU A 170
GLU A 168
LYS A 255
GLN A 293
 None
PGO  A2602 ( 2.6A)
None
None
None
 1.44A 4njiB-1uc4A:
1.3		 4njiB-1uc4A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 GLU A 329
GLU A 170
GLU A 168
LYS A 255
GLN A 293
 None
PGO  A2602 ( 2.6A)
None
None
None
 1.43A 4njkB-1uc4A:
1.3		 4njkB-1uc4A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		6 / 12 ILE A 154
ILE A 411
GLY A 193
ALA A 159
SER A 190
LEU A 186
 None
 1.44A 4o1zA-1uc4A:
undetectable		 4o1zA-1uc4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 4 ALA A 155
ALA A 158
ALA A 159
ALA A 162
 None
 0.12A 4oadA-1uc4A:
0.0		 4oadA-1uc4A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 4 ALA A 155
ALA A 158
ALA A 159
ALA A 162
 None
 0.11A 4oaeA-1uc4A:
0.0		 4oaeA-1uc4A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ILE B 168
GLY B 169
ALA B 176
ARG B 166
VAL B  91
 None
 1.07A 4rvgA-1uc4B:
undetectable		 4rvgA-1uc4B:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 MET A 213
GLN A 200
TYR A 219
 None
K  A2603 ( 4.8A)
None
 0.74A 4udcA-1uc4A:
undetectable		 4udcA-1uc4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ALA A 506
GLU A 329
GLY A 294
PHE A 359
GLN A 141
 None
None
None
None
K  A2603 (-3.2A)
 1.00A 4uilH-1uc4A:
undetectable
4uilL-1uc4A:
undetectable		 4uilH-1uc4A:
17.61
4uilL-1uc4A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ALA A 506
GLU A 329
PHE A 359
GLN A 141
GLN A 200
 None
None
None
K  A2603 (-3.2A)
K  A2603 ( 4.8A)
 1.08A 4uilH-1uc4A:
undetectable
4uilL-1uc4A:
undetectable		 4uilH-1uc4A:
17.61
4uilL-1uc4A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 ASP A  60
ASP A  63
ILE A  71
ASP A  52
 None
 0.89A 4xjeA-1uc4A:
undetectable		 4xjeA-1uc4A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 TYR A 364
SER A 365
SER A 202
ALA A 174
ASN A 182
 None
None
PGO  A2602 ( 4.6A)
None
None
 1.29A 4ymgB-1uc4A:
undetectable		 4ymgB-1uc4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 SER A 118
GLU A  22
GLU A  25
 None
 0.70A 4ymgB-1uc4A:
2.2		 4ymgB-1uc4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 ASP A  60
ASP A  63
ILE A  71
ASP A  52
 None
 0.96A 5cfsA-1uc4A:
undetectable		 5cfsA-1uc4A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 VAL A  20
ALA A 308
GLY A 304
GLY A 263
 None
 0.82A 5e26C-1uc4A:
undetectable
5e26D-1uc4A:
undetectable		 5e26C-1uc4A:
21.84
5e26D-1uc4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 7 ILE B 205
GLY A 269
PHE B  71
PHE B 108
 None
 0.87A 5hieB-1uc4B:
undetectable		 5hieB-1uc4B:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 ILE B 205
GLY A 269
PHE B  71
PHE B 108
 None
 0.88A 5hieD-1uc4B:
undetectable		 5hieD-1uc4B:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 9 ILE B 132
THR B 164
ARG B 166
ILE B 168
GLY B 169
 None
 1.29A 5ifuB-1uc4B:
3.3		 5ifuB-1uc4B:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 5 PRO A 110
ALA A 281
ILE A 322
LEU A 326
 None
 0.76A 5jncD-1uc4A:
undetectable		 5jncD-1uc4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 LEU A  51
ALA A  76
ILE A 113
PRO A  39
ILE A  41
 None
 1.09A 5kqyA-1uc4A:
undetectable		 5kqyA-1uc4A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ILE A 463
VAL A 422
MET A 489
CYH A 218
GLU A 472
 None
 1.41A 5mqtA-1uc4A:
0.6		 5mqtA-1uc4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 HIS B 204
SER B 200
LYS B 135
 None
CNC  B2601 (-2.7A)
CNC  B2601 (-2.8A)
 1.26A 5os7A-1uc4B:
undetectable		 5os7A-1uc4B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		6 / 12 LEU B 151
ALA B 172
ILE B 168
VAL B  91
ILE B  64
ILE B 140
 None
 1.42A 5t8hB-1uc4B:
undetectable		 5t8hB-1uc4B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 ILE B 130
ALA B 117
LEU B 153
ILE B 132
 None
None
CNC  B2601 (-4.0A)
None
 0.83A 5uihA-1uc4B:
undetectable		 5uihA-1uc4B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 ARG A 194
ARG A 537
ARG A 164
 None
 0.76A 5vcgA-1uc4A:
undetectable		 5vcgA-1uc4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca;
Klebsiella
oxytoca) 		5 / 12 GLN B 197
GLY A 261
SER A 307
ILE A 313
GLY A 298
 CNC  B2601 ( 4.6A)
NH4  A2604 (-4.1A)
None
None
None
 1.03A 5wyqA-1uc4B:
undetectable		 5wyqA-1uc4B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca;
Klebsiella
oxytoca) 		5 / 12 GLN B 197
GLY A 261
SER A 307
ILE A 313
GLY A 298
 CNC  B2601 ( 4.6A)
NH4  A2604 (-4.1A)
None
None
None
 0.97A 5wyqB-1uc4B:
undetectable		 5wyqB-1uc4B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 6 HIS A 216
MET A 426
ASN A 465
LEU A 428
 None
 1.37A 5xdhA-1uc4A:
0.0
5xdhC-1uc4A:
0.0		 5xdhA-1uc4A:
10.91
5xdhC-1uc4A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 THR A 287
ILE A 286
LEU A 254
PHE A 232
LEU A 209
 None
 1.43A 6a93A-1uc4A:
undetectable		 6a93A-1uc4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 7 ILE B 128
GLN B 142
ILE B 130
THR B 138
 None
 0.85A 6cduF-1uc4B:
undetectable
6cduG-1uc4B:
undetectable		 6cduF-1uc4B:
22.02
6cduG-1uc4B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 LEU A  51
ALA A  76
ILE A 113
PRO A  39
ILE A  41
 None
 1.21A 6difA-1uc4A:
undetectable		 6difA-1uc4A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 HIS B 204
SER B 200
LYS B 135
 None
CNC  B2601 (-2.7A)
CNC  B2601 (-2.8A)
 1.26A 6gmdB-1uc4B:
undetectable		 6gmdB-1uc4B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ASN B  78
ILE B 132
VAL B  91
ILE B  65
PHE B  47
 None
 1.20A 6hlpA-1uc4B:
undetectable		 6hlpA-1uc4B:
18.09