SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		3 / 3 ALA A  85
VAL A  94
TRP A  90
 None
 0.95A 1gmkC-1uc8A:
undetectable
1gmkD-1uc8A:
undetectable		 1gmkC-1uc8A:
10.31
1gmkD-1uc8A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 8 GLU A  13
CYH A  56
LEU A  53
ALA A  52
LEU A   2
 None
 1.35A 1hwiD-1uc8A:
undetectable		 1hwiD-1uc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 11 GLU A  13
CYH A  56
LEU A  53
ALA A  52
LEU A   2
 None
 1.33A 1hwkB-1uc8A:
0.0		 1hwkB-1uc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 11 GLU A  13
CYH A  56
LEU A  53
ALA A  52
LEU A   2
 None
 1.33A 1hwkA-1uc8A:
0.0		 1hwkA-1uc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 11 GLU A  13
CYH A  56
LEU A  53
ALA A  52
LEU A   2
 None
 1.33A 1hwkD-1uc8A:
0.0		 1hwkD-1uc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 11 GLU A  13
CYH A  56
LEU A  53
ALA A  52
LEU A   2
 None
 1.33A 1hwkC-1uc8A:
0.0		 1hwkC-1uc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 10 HIS A 252
VAL A 236
VAL A 234
ALA A  95
ALA A 228
 None
 1.05A 1likA-1uc8A:
4.2		 1likA-1uc8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		3 / 3 GLU A 120
GLU A 114
LEU A 128
 None
 0.76A 1v8bB-1uc8A:
undetectable		 1v8bB-1uc8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		4 / 5 SER A 280
LEU A  72
GLY A  73
ARG A  42
 None
 1.11A 2j2pA-1uc8A:
undetectable
2j2pB-1uc8A:
undetectable		 2j2pA-1uc8A:
17.79
2j2pB-1uc8A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 12 SER A  58
THR A 253
VAL A  76
ALA A  52
VAL A  32
 None
 1.26A 2nniA-1uc8A:
undetectable		 2nniA-1uc8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		4 / 4 LEU A  46
ALA A  52
VAL A  76
PRO A  75
 None
 1.15A 3gv1B-1uc8A:
1.6		 3gv1B-1uc8A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		4 / 6 LEU A  53
ALA A 279
THR A  50
LEU A  25
 None
 0.93A 3t3zA-1uc8A:
undetectable		 3t3zA-1uc8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		4 / 6 LEU A  53
ALA A 279
THR A  50
LEU A  25
 None
 0.90A 3t3zB-1uc8A:
undetectable		 3t3zB-1uc8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		4 / 6 LEU A  53
ALA A 279
THR A  50
LEU A  25
 None
 0.91A 3t3zD-1uc8A:
undetectable		 3t3zD-1uc8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 12 PHE A 256
LEU A  53
GLY A 269
VAL A 184
ALA A  20
 None
 1.10A 4a6dA-1uc8A:
undetectable		 4a6dA-1uc8A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 12 PHE A 256
LEU A  53
GLY A 269
VAL A 184
ALA A  20
 None
 1.14A 4a6eA-1uc8A:
undetectable		 4a6eA-1uc8A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		3 / 3 LYS A 129
PRO A 130
LYS A  89
 None
 1.48A 4dv7L-1uc8A:
0.0		 4dv7L-1uc8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		3 / 3 ILE A 271
ILE A   4
MET A 254
 None
 0.62A 5i9yA-1uc8A:
undetectable		 5i9yA-1uc8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		5 / 12 ALA A 235
SER A 222
LEU A 238
TYR A 167
VAL A 229
 None
 1.26A 5vlmH-1uc8A:
0.1		 5vlmH-1uc8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1uc8 LYSINE BIOSYNTHESIS
ENZYME
(Thermus
thermophilus) 		3 / 3 ARG A  10
PHE A 256
ARG A  55
 None
 1.19A 5y9yA-1uc8A:
0.0		 5y9yA-1uc8A:
20.34