SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		5 / 12 LEU A  55
LEU A  53
ALA A 105
ALA A 103
LEU A   7
 None
 1.34A 1kt5A-1uchA:
0.0		 1kt5A-1uchA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		5 / 11 GLY A  96
GLY A  99
LEU A  53
LEU A  55
HIS A 169
 None
 0.86A 1mx1A-1uchA:
undetectable		 1mx1A-1uchA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		3 / 3 PHE A  31
LEU A 100
LEU A   7
 None
 0.67A 1mx1E-1uchA:
undetectable		 1mx1E-1uchA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		5 / 9 PHE A 122
LEU A 138
TYR A 137
LEU A  23
ARG A   5
 None
 1.09A 2bfmA-1uchA:
0.0
2bfmD-1uchA:
undetectable		 2bfmA-1uchA:
22.04
2bfmD-1uchA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_B_TOPB1290_1
(PTERIDINE REDUCTASE
1)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		5 / 9 PHE A 122
LEU A 138
TYR A 137
LEU A  23
ARG A   5
 None
 1.11A 2bfmB-1uchA:
0.0
2bfmC-1uchA:
0.0		 2bfmB-1uchA:
22.04
2bfmC-1uchA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 7 ILE A 225
LEU A 100
GLY A  99
PHE A 170
 None
 0.88A 2tsrA-1uchA:
undetectable		 2tsrA-1uchA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 8 ILE A 225
LEU A 100
GLY A  99
PHE A 170
 None
 0.87A 2tsrB-1uchA:
undetectable		 2tsrB-1uchA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		5 / 10 ILE A 101
TYR A 137
TYR A 141
LEU A  23
LEU A  25
 None
 1.50A 2w98A-1uchA:
undetectable		 2w98A-1uchA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		5 / 12 ILE A  98
GLY A  99
ILE A 171
ASP A 184
GLY A 185
 None
 0.78A 3bwcA-1uchA:
undetectable		 3bwcA-1uchA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 7 HIS A 169
GLU A  70
ARG A 186
PHE A  86
 None
 1.34A 3ql6A-1uchA:
undetectable		 3ql6A-1uchA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 7 ILE A 225
LEU A 100
GLY A  99
PHE A 170
 None
 0.86A 4iqqB-1uchA:
undetectable		 4iqqB-1uchA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 8 ILE A 225
LEU A 100
GLY A  99
PHE A 170
 None
 0.85A 4iqqD-1uchA:
undetectable		 4iqqD-1uchA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 6 ASN A 106
ASP A 109
THR A  81
VAL A 176
 None
 1.13A 4yoaA-1uchA:
undetectable		 4yoaA-1uchA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 6 ILE A 171
PHE A 212
ILE A 191
GLU A  69
 None
 1.22A 4zzcA-1uchA:
undetectable
4zzcB-1uchA:
undetectable		 4zzcA-1uchA:
22.15
4zzcB-1uchA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 6 ILE A 171
PHE A 212
ILE A 191
GLU A  69
 None
 1.14A 4zzcB-1uchA:
undetectable
4zzcC-1uchA:
undetectable		 4zzcB-1uchA:
22.15
4zzcC-1uchA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 7 ARG A 215
ARG A 186
ASP A 184
ILE A 171
 None
 1.16A 5a06B-1uchA:
undetectable		 5a06B-1uchA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 7 PHE A  56
ARG A 186
ASP A 184
ILE A 171
 None
 1.35A 5a06B-1uchA:
undetectable		 5a06B-1uchA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 8 GLU A 182
PHE A 170
GLY A  99
PHE A 212
 None
 0.97A 5flcB-1uchA:
0.0		 5flcB-1uchA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 8 GLU A 182
PHE A 170
GLY A  99
PHE A 212
 None
 0.97A 5flcF-1uchA:
undetectable		 5flcF-1uchA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 7 ILE A 225
LEU A 100
GLY A  99
PHE A 170
 None
 0.85A 5nooB-1uchA:
undetectable		 5nooB-1uchA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens) 		4 / 8 ILE A 225
LEU A 100
GLY A  99
PHE A 170
 None
 0.89A 5nooD-1uchA:
undetectable		 5nooD-1uchA:
20.69