SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1udd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		4 / 8 GLU A 204
LEU A  53
ALA A  56
LEU A  57
 None
 0.73A 1hwiD-1uddA:
undetectable		 1hwiD-1uddA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		5 / 12 GLU A 204
ILE A 143
TYR A  30
ALA A 211
TYR A  42
 None
 1.39A 1ki7A-1uddA:
undetectable		 1ki7A-1uddA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		5 / 12 LEU A 130
LEU A 133
GLU A 204
LEU A  75
ILE A 181
 None
 0.88A 1s9pD-1uddA:
2.2		 1s9pD-1uddA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		4 / 7 GLY A 124
THR A 131
ILE A 196
GLY A 129
 None
 0.85A 1usqA-1uddA:
undetectable		 1usqA-1uddA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		4 / 8 TYR A  42
CYH A 136
TYR A  49
TRP A 162
 None
 1.49A 1uw6D-1uddA:
undetectable
1uw6E-1uddA:
undetectable		 1uw6D-1uddA:
22.18
1uw6E-1uddA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VET_A_TOYA604_1
(O-CARBAMOYLTRANSFERA
SE TOBZ)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		5 / 9 TYR A 171
PHE A 207
GLU A 204
ASP A  46
TYR A  49
 None
 1.28A 3vetA-1uddA:
0.4		 3vetA-1uddA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		4 / 7 LEU A  50
ALA A 101
ASP A 100
VAL A  43
 None
 0.99A 4eyrA-1uddA:
undetectable		 4eyrA-1uddA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		4 / 5 ILE A   5
SER A 188
HIS A 187
ASP A  12
 None
 1.34A 4rzvB-1uddA:
0.6		 4rzvB-1uddA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		5 / 12 ALA A 121
LEU A  57
ILE A 181
LEU A  68
ILE A 126
 None
 0.95A 4x5iA-1uddA:
undetectable		 4x5iA-1uddA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		4 / 7 TRP A 208
TRP A  17
PHE A  21
GLU A 204
 None
 1.48A 5vvaA-1uddA:
0.0
5vvaB-1uddA:
0.0		 5vvaA-1uddA:
18.20
5vvaB-1uddA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1udd TRANSCRIPTIONAL
REGULATOR
(Pyrococcus
horikoshii) 		4 / 8 ILE A   5
THR A   6
GLU A  14
SER A  13
 None
 0.83A 6c06C-1uddA:
undetectable		 6c06C-1uddA:
undetectable