SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1udq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 10 VAL A  14
VAL A 164
VAL A 162
ILE A 229
LEU A  11
 None
 1.00A 1fe2A-1udqA:
0.0		 1fe2A-1udqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 10 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.00A 1fk9A-1udqA:
undetectable		 1fk9A-1udqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 10 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 0.93A 1fkoA-1udqA:
undetectable		 1fkoA-1udqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 11 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 0.99A 1fkpA-1udqA:
undetectable		 1fkpA-1udqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 8 VAL A  14
VAL A 164
VAL A 162
ILE A 229
LEU A  11
 None
 1.12A 1igxA-1udqA:
undetectable		 1igxA-1udqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 11 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.08A 1jkhA-1udqA:
0.7
1jkhB-1udqA:
undetectable		 1jkhA-1udqA:
19.43
1jkhB-1udqA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 10 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.00A 1lw0A-1udqA:
undetectable		 1lw0A-1udqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 9 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.05A 1vrtA-1udqA:
undetectable		 1vrtA-1udqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 12 LEU A 214
LEU A 220
ALA A 221
LEU A 175
ARG A   2
 None
 1.27A 2oaxB-1udqA:
undetectable		 2oaxB-1udqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 12 LEU A 214
LEU A 220
ALA A 221
LEU A 175
ARG A   2
 None
 1.23A 2oaxD-1udqA:
undetectable		 2oaxD-1udqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 12 LEU A 214
LEU A 220
ALA A 221
LEU A 175
ARG A   2
 None
 1.28A 2oaxE-1udqA:
undetectable		 2oaxE-1udqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 12 ILE A 130
THR A 131
ASN A 226
ILE A 225
VAL A 189
 None
 1.04A 3kpdC-1udqA:
undetectable		 3kpdC-1udqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 11 ILE A 112
ILE A 150
ALA A 140
ILE A 155
VAL A 102
 None
 0.89A 3kw4A-1udqA:
undetectable		 3kw4A-1udqA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 10 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.10A 3lp1A-1udqA:
undetectable		 3lp1A-1udqA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 12 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.01A 3mecA-1udqA:
undetectable		 3mecA-1udqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 12 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.02A 3medA-1udqA:
undetectable
3medB-1udqA:
undetectable		 3medA-1udqA:
19.61
3medB-1udqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 10 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.05A 3qipA-1udqA:
undetectable		 3qipA-1udqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		4 / 6 LEU A 248
GLN A 232
LEU A 231
GLU A 230
 None
 1.21A 4nc3A-1udqA:
undetectable		 4nc3A-1udqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		3 / 3 ASP A 174
ASN A 188
SER A  31
 None
PO4  A 701 ( 4.8A)
None
 0.83A 4obwA-1udqA:
undetectable		 4obwA-1udqA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		4 / 8 LEU A 214
VAL A 164
VAL A 185
LEU A 218
 None
 0.96A 4pwdA-1udqA:
undetectable		 4pwdA-1udqA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		3 / 3 SER A 198
ASP A 139
ASP A 157
 None
 0.79A 4uckA-1udqA:
undetectable		 4uckA-1udqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		3 / 3 MET A 187
GLN A 184
TYR A 207
 None
 0.98A 4udcA-1udqA:
undetectable		 4udcA-1udqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 11 ASP A 139
ILE A 112
ILE A 155
ILE A  30
ILE A  16
 None
 1.11A 5hw8A-1udqA:
undetectable
5hw8D-1udqA:
undetectable		 5hw8A-1udqA:
19.12
5hw8D-1udqA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		3 / 3 LYS A  34
ASP A 122
ARG A   6
 None
 1.10A 5jwaA-1udqA:
undetectable
5jwaH-1udqA:
undetectable		 5jwaA-1udqA:
18.52
5jwaH-1udqA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		4 / 6 ASP A 169
ASP A 180
ASN A 176
ASN A 168
 None
 1.26A 5l6eA-1udqA:
undetectable		 5l6eA-1udqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		4 / 7 GLY A 123
SER A 163
ARG A  68
ASP A 180
 PO4  A 701 (-3.6A)
None
None
None
 0.82A 5n5dB-1udqA:
undetectable		 5n5dB-1udqA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 12 ARG A  99
GLY A  57
GLY A 108
ILE A 150
GLU A 152
 SO4  A 911 (-4.2A)
None
None
None
None
 1.04A 5ul4A-1udqA:
undetectable		 5ul4A-1udqA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 10 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.14A 6bsgA-1udqA:
undetectable		 6bsgA-1udqA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 10 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.12A 6bsjA-1udqA:
undetectable		 6bsjA-1udqA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1udq RIBONUCLEASE PH
(Aquifex
aeolicus) 		5 / 7 ILE A  94
VAL A 114
TRP A 113
ILE A  59
THR A 111
 None
 1.35A 6cduF-1udqA:
undetectable
6cduG-1udqA:
undetectable		 6cduF-1udqA:
20.73
6cduG-1udqA:
20.73