SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ue0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 8 PHE A 209
THR A 228
PRO A 292
LEU A 234
 None
 0.82A 1hmyA-1ue0A:
undetectable		 1hmyA-1ue0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 PHE A 209
TYR A 289
GLY A 236
THR A 233
 None
None
None
VAL  A 400 (-3.6A)
 0.93A 2a1mA-1ue0A:
undetectable		 2a1mA-1ue0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 LEU A 287
ALA A 250
LEU A 258
SER A 223
LEU A 211
 None
 1.26A 2c12F-1ue0A:
undetectable		 2c12F-1ue0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 LEU A 234
THR A 233
GLY A 325
ASP A 328
 None
VAL  A 400 (-3.6A)
None
VAL  A 400 (-2.7A)
 0.98A 2ddwB-1ue0A:
undetectable		 2ddwB-1ue0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 VAL A 238
LEU A 339
PHE A 324
THR A 342
 None
 1.08A 2f78A-1ue0A:
undetectable		 2f78A-1ue0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 7 VAL A 238
LEU A 339
PHE A 324
THR A 342
 None
 1.03A 2f78B-1ue0A:
undetectable		 2f78B-1ue0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 4 ALA A 240
VAL A 238
PHE A 302
THR A 331
 None
 1.37A 2pkkA-1ue0A:
undetectable		 2pkkA-1ue0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		3 / 3 LYS A 378
GLU A 380
TRP A 227
 None
 1.38A 3v4tH-1ue0A:
0.0		 3v4tH-1ue0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		4 / 5 ALA A 332
TYR A 335
GLY A 265
LEU A 284
 None
 0.87A 5eslA-1ue0A:
undetectable		 5eslA-1ue0A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 11 GLY A 316
GLY A 314
SER A 223
ARG A 266
GLU A 262
 None
 0.93A 5o96G-1ue0A:
undetectable		 5o96G-1ue0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 7 GLY A 281
LEU A 284
LEU A 276
ILE A 317
GLY A 316
 None
 1.15A 5vkqA-1ue0A:
undetectable
5vkqB-1ue0A:
undetectable		 5vkqA-1ue0A:
7.40
5vkqB-1ue0A:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 8 GLY A 281
LEU A 284
LEU A 276
ILE A 317
GLY A 316
 None
 1.13A 5vkqB-1ue0A:
undetectable
5vkqC-1ue0A:
undetectable		 5vkqB-1ue0A:
7.40
5vkqC-1ue0A:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 GLY A 356
LEU A 357
THR A 342
VAL A 351
VAL A 343
 None
 1.12A 6czmA-1ue0A:
undetectable
6czmC-1ue0A:
undetectable		 6czmA-1ue0A:
21.51
6czmC-1ue0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 VAL A 343
GLY A 356
LEU A 357
THR A 342
VAL A 351
 None
 1.13A 6czmA-1ue0A:
undetectable
6czmB-1ue0A:
undetectable		 6czmA-1ue0A:
21.51
6czmB-1ue0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 VAL A 343
GLY A 356
LEU A 357
THR A 342
VAL A 351
 None
 1.13A 6czmB-1ue0A:
undetectable
6czmC-1ue0A:
undetectable		 6czmB-1ue0A:
21.51
6czmC-1ue0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 9 VAL A 343
GLY A 356
LEU A 357
THR A 342
VAL A 351
 None
 1.13A 6czmD-1ue0A:
undetectable
6czmE-1ue0A:
undetectable		 6czmD-1ue0A:
21.51
6czmE-1ue0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ue0 ISOLEUCYL-TRNA
SYNTHETASE
(Thermus
thermophilus) 		5 / 10 VAL A 343
GLY A 356
LEU A 357
THR A 342
VAL A 351
 None
 1.14A 6czmE-1ue0A:
undetectable
6czmF-1ue0A:
undetectable		 6czmE-1ue0A:
21.51
6czmF-1ue0A:
21.51