SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ue8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 8 PHE A 118
GLY A 220
VAL A 244
PHE A 334
 None
 1.23A 1gsfA-1ue8A:
undetectable		 1gsfA-1ue8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 8 PHE A 118
GLY A 220
VAL A 244
PHE A 334
 None
 1.24A 1gsfB-1ue8A:
undetectable		 1gsfB-1ue8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 8 PHE A 118
GLY A 220
VAL A 244
PHE A 334
 None
 1.23A 1gsfD-1ue8A:
undetectable		 1gsfD-1ue8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 6 GLU A 326
LEU A 322
LEU A 131
GLY A 132
 None
HEM  A 410 ( 4.9A)
None
None
 0.92A 1n13H-1ue8A:
undetectable
1n13K-1ue8A:
undetectable		 1n13H-1ue8A:
16.99
1n13K-1ue8A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		5 / 10 ALA A 323
ALA A 327
LEU A 331
ALA A 222
SER A 309
 HEM  A 410 (-3.4A)
None
None
None
None
 0.93A 2bxgB-1ue8A:
undetectable		 2bxgB-1ue8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 6 LEU A 122
VAL A  97
ILE A 329
ILE A 219
 None
 0.83A 2piwA-1ue8A:
undetectable		 2piwA-1ue8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 5 TYR A 203
ILE A 190
LEU A 131
LEU A 186
 None
 1.18A 2zb7A-1ue8A:
undetectable		 2zb7A-1ue8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		3 / 3 ALA A 210
THR A 214
CYH A 317
 HEM  A 410 (-4.2A)
HEM  A 410 (-4.1A)
HEM  A 410 (-2.3A)
 0.51A 3e4eA-1ue8A:
31.0		 3e4eA-1ue8A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		3 / 3 ALA A 210
THR A 214
CYH A 317
 HEM  A 410 (-4.2A)
HEM  A 410 (-4.1A)
HEM  A 410 (-2.3A)
 0.38A 3e4eB-1ue8A:
30.8		 3e4eB-1ue8A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 6 GLU A 246
PRO A 300
ARG A 249
HIS A 307
 None
 1.11A 3ltwA-1ue8A:
undetectable		 3ltwA-1ue8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 6 GLU A 166
ASP A 142
ASP A 136
LYS A 138
 None
 1.38A 3pocB-1ue8A:
undetectable		 3pocB-1ue8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A 126
THR A 216
ILE A 115
LEU A 104
VAL A 100
 None
 1.23A 3sp9B-1ue8A:
undetectable		 3sp9B-1ue8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 7 PRO A 123
LEU A 104
LEU A 105
ILE A 219
 None
 0.76A 3u5jA-1ue8A:
undetectable		 3u5jA-1ue8A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 8 PRO A 123
LEU A 104
LEU A 105
ILE A 219
 None
 0.75A 3u5kD-1ue8A:
undetectable		 3u5kD-1ue8A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		5 / 11 LEU A 122
ARG A 328
LEU A 325
GLU A 332
VAL A 102
 None
 1.49A 3ua5A-1ue8A:
12.8		 3ua5A-1ue8A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  38
LYS A 264
LYS A 266
 None
 1.27A 4k50A-1ue8A:
0.0		 4k50A-1ue8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  38
LYS A 264
LYS A 266
 None
 1.28A 4k50E-1ue8A:
undetectable		 4k50E-1ue8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  38
LYS A 264
LYS A 266
 None
 1.32A 4k50I-1ue8A:
undetectable		 4k50I-1ue8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		3 / 3 ILE A 349
MET A 255
ARG A 256
 None
 0.82A 4lnwA-1ue8A:
undetectable		 4lnwA-1ue8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		3 / 3 ILE A 349
MET A 255
ARG A 256
 None
 0.79A 4lnxA-1ue8A:
undetectable		 4lnxA-1ue8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A 349
VAL A 361
LEU A 360
ILE A 343
 None
 0.88A 4r38D-1ue8A:
undetectable		 4r38D-1ue8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 168
TYR A 164
VAL A 137
GLY A 202
THR A  67
 None
 1.28A 5esgA-1ue8A:
26.6		 5esgA-1ue8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 207
ILE A 124
ASP A 142
LEU A 206
ALA A 210
 None
None
None
HEM  A 410 ( 4.8A)
HEM  A 410 (-4.2A)
 1.11A 5h5fA-1ue8A:
undetectable		 5h5fA-1ue8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 6 ASP A 225
ILE A 299
ARG A 302
TYR A   2
 None
 1.03A 5igyA-1ue8A:
undetectable		 5igyA-1ue8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 6 ASP A 225
ILE A 299
ARG A 302
TYR A   2
 None
 1.14A 5iwuA-1ue8A:
0.0		 5iwuA-1ue8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450
(Sulfurisphaera
tokodaii) 		4 / 8 VAL A 353
ASN A 217
ILE A 349
GLU A 213
 None
 0.99A 6hzpA-1ue8A:
undetectable		 6hzpA-1ue8A:
21.21