SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ued'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 164
LEU A 165
GLY A 166
MET A 365
ALA A 127
 None
 1.06A 1gs4A-1uedA:
undetectable		 1gs4A-1uedA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 11 CYH A 356
HIS A 105
SER A  98
ALA A 241
LEU A 238
 HEM  A1430 (-2.4A)
HEM  A1430 (-3.9A)
PG4  A4502 ( 3.6A)
PG4  A4502 (-4.3A)
None
 1.30A 1hwkB-1uedA:
0.0		 1hwkB-1uedA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 11 CYH A 356
HIS A 105
SER A  98
ALA A 241
LEU A 238
 HEM  A1430 (-2.4A)
HEM  A1430 (-3.9A)
PG4  A4502 ( 3.6A)
PG4  A4502 (-4.3A)
None
 1.28A 1hwkA-1uedA:
0.0		 1hwkA-1uedA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 11 CYH A 356
HIS A 105
SER A  98
ALA A 241
LEU A 238
 HEM  A1430 (-2.4A)
HEM  A1430 (-3.9A)
PG4  A4502 ( 3.6A)
PG4  A4502 (-4.3A)
None
 1.29A 1hwkD-1uedA:
0.0		 1hwkD-1uedA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 11 CYH A 356
HIS A 105
SER A  98
ALA A 241
LEU A 238
 HEM  A1430 (-2.4A)
HEM  A1430 (-3.9A)
PG4  A4502 ( 3.6A)
PG4  A4502 (-4.3A)
None
 1.28A 1hwkC-1uedA:
0.0		 1hwkC-1uedA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 ARG A 392
GLY A 150
ASP A 154
 None
 0.57A 1kf6A-1uedA:
undetectable
1kf6B-1uedA:
undetectable		 1kf6A-1uedA:
21.60
1kf6B-1uedA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		6 / 11 LEU A 148
PHE A 152
GLY A 257
VAL A 281
LEU A 285
LEU A 380
 None
 1.36A 1mx1A-1uedA:
undetectable		 1mx1A-1uedA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 ASP A 327
ILE A  67
PRO A 295
ALA A 294
 None
None
HEM  A1430 (-4.6A)
None
 0.68A 1n49A-1uedA:
undetectable		 1n49A-1uedA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 8 ALA A 160
LEU A 161
GLY A 246
GLY A 358
 None
None
HEM  A1430 (-3.3A)
HEM  A1430 ( 3.9A)
 0.84A 1rukH-1uedA:
undetectable
1rukL-1uedA:
undetectable		 1rukH-1uedA:
18.72
1rukL-1uedA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 242
LEU A 161
GLN A 172
LEU A 361
MET A 365
 HEM  A1430 ( 4.5A)
None
None
HEM  A1430 ( 4.9A)
None
 1.32A 1sqnA-1uedA:
2.5		 1sqnA-1uedA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 ASP A 397
PHE A 256
ARG A  21
 None
 0.70A 2a3aA-1uedA:
undetectable		 2a3aA-1uedA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 8 PHE A 175
LEU A 203
TYR A 202
LEU A 219
LEU A 218
 None
 1.36A 2bfpC-1uedA:
undetectable		 2bfpC-1uedA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 10 ILE A 121
ALA A 360
PRO A 126
GLU A 125
ILE A 128
 None
 1.18A 2dm6A-1uedA:
undetectable
2dm6B-1uedA:
undetectable		 2dm6A-1uedA:
22.82
2dm6B-1uedA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 ARG A 326
GLU A 284
ASN A 264
ALA A 260
 None
 1.09A 2ejgB-1uedA:
undetectable		 2ejgB-1uedA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 SER A 290
HIS A  59
ASP A 307
 None
 0.64A 2oxtA-1uedA:
undetectable		 2oxtA-1uedA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 SER A 290
GLY A 348
HIS A  59
ASP A 307
 None
 0.66A 2oxtB-1uedA:
undetectable		 2oxtB-1uedA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 242
LEU A 161
GLN A 172
LEU A 361
MET A 365
 HEM  A1430 ( 4.5A)
None
None
HEM  A1430 ( 4.9A)
None
 1.33A 2w8yB-1uedA:
3.1		 2w8yB-1uedA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 VAL A  64
TYR A  61
ASP A 346
SER A 290
 None
 1.32A 2x45A-1uedA:
undetectable		 2x45A-1uedA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 5 VAL A  64
TYR A  61
ASP A 346
SER A 290
 None
 1.34A 2x45C-1uedA:
undetectable		 2x45C-1uedA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 ARG A 326
GLU A 284
ASN A 264
ALA A 260
 None
 0.99A 2zgwA-1uedA:
undetectable		 2zgwA-1uedA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 242
LEU A 161
GLN A 172
LEU A 361
MET A 365
 HEM  A1430 ( 4.5A)
None
None
HEM  A1430 ( 4.9A)
None
 1.35A 3d90A-1uedA:
undetectable		 3d90A-1uedA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 366
GLY A 257
TRP A 374
VAL A 156
PHE A 152
 None
 1.22A 3gn8B-1uedA:
2.8		 3gn8B-1uedA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 VAL A 282
VAL A 286
LEU A 289
SER A 290
 None
 0.89A 3hs6B-1uedA:
undetectable		 3hs6B-1uedA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 11 ASN A  23
LEU A 289
ALA A 153
VAL A 402
LEU A 380
 None
 1.38A 3jwqB-1uedA:
undetectable
3jwqC-1uedA:
undetectable		 3jwqB-1uedA:
19.57
3jwqC-1uedA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 11 LEU A 244
GLY A 245
THR A 249
VAL A 292
VAL A 396
 PG4  A4502 ( 4.3A)
PG4  A4502 ( 3.7A)
HEM  A1430 (-3.5A)
HEM  A1430 (-4.4A)
None
 1.06A 3lxiB-1uedA:
37.3		 3lxiB-1uedA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 GLY A 245
GLY A 246
LEU A 164
PHE A 116
 PG4  A4502 ( 3.7A)
HEM  A1430 (-3.3A)
None
HEM  A1430 (-4.7A)
 0.60A 3o9mA-1uedA:
undetectable		 3o9mA-1uedA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A 245
GLY A 358
LEU A  68
VAL A 292
ALA A 294
 PG4  A4502 ( 3.7A)
HEM  A1430 ( 3.9A)
HEM  A1430 ( 4.9A)
HEM  A1430 (-4.4A)
None
 1.25A 3t7vA-1uedA:
undetectable		 3t7vA-1uedA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 6 MET A 253
LEU A 289
PRO A  26
TYR A 288
 HEM  A1430 (-4.6A)
None
None
None
 1.02A 3vkxA-1uedA:
undetectable		 3vkxA-1uedA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 11 GLN A  19
PHE A  18
ARG A  41
ILE A  42
SER A  46
 None
 1.15A 4bb2A-1uedA:
0.0
4bb2B-1uedA:
0.0		 4bb2A-1uedA:
23.46
4bb2B-1uedA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 PHE A 116
ALA A 241
LEU A 165
LEU A 218
 HEM  A1430 (-4.7A)
PG4  A4502 (-4.3A)
None
None
 0.92A 4ejgC-1uedA:
28.9		 4ejgC-1uedA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 8 LEU A 165
LEU A 161
ILE A 222
VAL A 357
 None
None
None
HEM  A1430 ( 4.9A)
 0.82A 4klaA-1uedA:
undetectable		 4klaA-1uedA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 LEU A 218
ASP A 215
ILE A 243
 None
 0.69A 4xi3D-1uedA:
undetectable		 4xi3D-1uedA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 6 ARG A 298
HIS A 105
ARG A 109
ILE A 353
 HEM  A1430 (-3.0A)
HEM  A1430 (-3.9A)
HEM  A1430 (-3.9A)
None
 1.37A 5a06A-1uedA:
undetectable		 5a06A-1uedA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 PHE A 175
LEU A 219
LEU A 207
PHE A 199
ALA A 241
 None
None
None
None
PG4  A4502 (-4.3A)
 1.24A 5ieoA-1uedA:
undetectable		 5ieoA-1uedA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		4 / 7 GLY A 246
THR A 249
VAL A 292
VAL A 396
 HEM  A1430 (-3.3A)
HEM  A1430 (-3.5A)
HEM  A1430 (-4.4A)
None
 0.77A 5ik1A-1uedA:
38.9		 5ik1A-1uedA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 VAL A 404
LEU A 289
MET A 253
 None
None
HEM  A1430 (-4.6A)
 0.83A 5ikrA-1uedA:
undetectable		 5ikrA-1uedA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 VAL A 404
LEU A 289
MET A 253
GLY A 257
LEU A 262
 None
None
HEM  A1430 (-4.6A)
None
None
 1.31A 5iktB-1uedA:
undetectable		 5iktB-1uedA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 PRO A 334
ARG A 326
GLU A 328
 None
 0.97A 5j6hA-1uedA:
undetectable		 5j6hA-1uedA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 161
LEU A 242
GLY A 245
LEU A 361
MET A 365
 None
HEM  A1430 ( 4.5A)
PG4  A4502 ( 3.7A)
HEM  A1430 ( 4.9A)
None
 1.09A 5uc1A-1uedA:
undetectable		 5uc1A-1uedA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 161
LEU A 242
GLY A 245
LEU A 361
MET A 365
 None
HEM  A1430 ( 4.5A)
PG4  A4502 ( 3.7A)
HEM  A1430 ( 4.9A)
None
 1.10A 5uc1B-1uedA:
undetectable		 5uc1B-1uedA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		5 / 12 PHE A 175
ILE A 179
PHE A 199
ALA A 241
GLU A 163
 None
None
None
PG4  A4502 (-4.3A)
None
 1.12A 5vceA-1uedA:
9.7		 5vceA-1uedA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ued P450 MONOOXYGENASE
(Amycolatopsis
orientalis) 		3 / 3 GLN A 309
TRP A  56
VAL A 317
 None
 0.90A 6auuA-1uedA:
undetectable		 6auuA-1uedA:
21.19