SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		4 / 5 TYR A 169
PRO A 205
LEU A 209
ARG A 162
 None
 1.39A 1i2wA-1uekA:
undetectable		 1i2wA-1uekA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 11 GLY A 232
GLY A  90
LEU A  91
GLY A  12
LEU A 229
 None
 1.13A 1jg3A-1uekA:
undetectable		 1jg3A-1uekA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 12 LEU A 265
GLY A 232
GLY A  90
LEU A 187
PRO A 182
 None
 1.04A 1p91B-1uekA:
undetectable		 1p91B-1uekA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		4 / 7 LEU A  48
ILE A  79
GLN A 100
ILE A  85
 None
 0.82A 2xkwA-1uekA:
undetectable		 2xkwA-1uekA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 12 GLY A  90
GLY A 232
LEU A 225
MET A 220
ALA A 260
 None
 1.21A 3t7vA-1uekA:
undetectable		 3t7vA-1uekA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 228
PHE A 237
GLY A 239
VAL A 155
PHE A 157
 None
 0.60A 4bvaA-1uekA:
undetectable		 4bvaA-1uekA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 228
PHE A 237
GLY A 239
VAL A 155
PHE A 157
 None
 0.65A 4bvaB-1uekA:
undetectable		 4bvaB-1uekA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 12 ARG A 162
GLY A  94
GLY A  93
GLY A  92
ALA A  60
 None
 0.84A 4htfA-1uekA:
undetectable		 4htfA-1uekA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 12 ARG A 162
GLY A  94
GLY A  93
GLY A  92
ALA A  60
 None
 0.86A 4htfB-1uekA:
undetectable		 4htfB-1uekA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 7 LEU A  59
ASN A  58
LEU A 102
ILE A  79
VAL A  41
 None
 1.44A 4ojbA-1uekA:
undetectable		 4ojbA-1uekA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		4 / 6 LEU A  59
ASN A  58
LEU A 102
VAL A  41
 None
 1.03A 4okbA-1uekA:
undetectable		 4okbA-1uekA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		4 / 6 LEU A  59
ASN A  58
LEU A 102
ILE A  79
 None
 0.88A 4okxA-1uekA:
undetectable		 4okxA-1uekA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		4 / 4 GLY A  75
VAL A  44
PHE A  50
ILE A  79
 None
 1.11A 4xv2B-1uekA:
undetectable		 4xv2B-1uekA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 12 ALA A   7
LEU A  35
GLY A  94
SER A  96
ALA A   5
 None
 1.17A 4ypmA-1uekA:
undetectable		 4ypmA-1uekA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 126
GLY A  94
SER A  95
VAL A  77
LEU A 105
 None
 1.02A 5ergB-1uekA:
undetectable		 5ergB-1uekA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		4 / 7 LEU A 147
PHE A  30
PHE A 116
LEU A 131
 None
 1.11A 6aycA-1uekA:
undetectable		 6aycA-1uekA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE
(Thermus
thermophilus) 		3 / 3 ARG A 162
GLY A  88
GLU A  87
 None
 0.58A 6fgdA-1uekA:
0.7		 6fgdA-1uekA:
21.87