SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		5 / 8 LEU A  90
ALA A  82
ILE A  65
ILE A  76
LEU A  59
 None
 1.16A 2o4nB-1uepA:
undetectable		 2o4nB-1uepA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		5 / 10 GLY A  29
GLN A  34
ILE A  26
VAL A  75
VAL A  67
 None
 1.28A 3fhjB-1uepA:
undetectable		 3fhjB-1uepA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		5 / 10 GLY A  29
GLN A  34
ILE A  26
VAL A  75
VAL A  67
 None
 1.28A 3fhjC-1uepA:
undetectable		 3fhjC-1uepA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		4 / 8 GLY A  29
ILE A  26
VAL A  75
VAL A  67
 None
 0.68A 3fi0B-1uepA:
undetectable		 3fi0B-1uepA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		4 / 8 GLY A  29
ILE A  26
VAL A  75
VAL A  67
 None
 0.69A 3fi0I-1uepA:
undetectable		 3fi0I-1uepA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		4 / 8 GLN A  34
ILE A  26
VAL A  75
VAL A  67
 None
 0.79A 3fi0Q-1uepA:
undetectable		 3fi0Q-1uepA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		4 / 8 GLY A  29
ILE A  26
VAL A  75
VAL A  67
 None
 0.65A 3fi0Q-1uepA:
undetectable		 3fi0Q-1uepA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		3 / 3 GLU A  31
GLY A  29
THR A  71
 None
 0.52A 3iazA-1uepA:
undetectable		 3iazA-1uepA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		5 / 12 ALA A  47
GLY A  45
GLY A  21
SER A  20
GLY A  51
 None
 0.96A 5gwxA-1uepA:
undetectable		 5gwxA-1uepA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		4 / 6 ARG A  16
HIS A  14
LEU A  90
SER A  46
 None
 1.50A 5syjA-1uepA:
undetectable		 5syjA-1uepA:
10.14