SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 1uew MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		4 / 6 VAL A  15
HIS A  17
SER A  94
THR A  96
 None
 0.47A 3tj7A-1uewA:
undetectable
3tj7B-1uewA:
undetectable		 3tj7A-1uewA:
14.57
3tj7B-1uewA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 1uew MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		4 / 6 VAL A  15
HIS A  17
SER A  94
THR A  96
 None
 0.45A 3tj7C-1uewA:
undetectable
3tj7D-1uewA:
undetectable		 3tj7C-1uewA:
14.57
3tj7D-1uewA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1uew MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		4 / 6 VAL A  15
HIS A  17
SER A  94
THR A  96
 None
 0.43A 3tj7C-1uewA:
undetectable
3tj7D-1uewA:
undetectable		 3tj7C-1uewA:
14.57
3tj7D-1uewA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1uew MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		5 / 12 VAL A  27
PHE A  26
GLY A  48
VAL A  64
SER A  54
 None
 1.45A 4bvaA-1uewA:
undetectable		 4bvaA-1uewA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uew MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)
(Homo
sapiens) 		5 / 10 LEU A  97
THR A  96
GLY A  73
PHE A  26
ILE A  88
 None
 1.25A 6ebpC-1uewA:
undetectable		 6ebpC-1uewA:
23.08