SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uf1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1uf1 KIAA1526 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A  96
ASN A  74
LEU A  89
PHE A  78
 None
 1.42A 1ru9H-1uf1A:
undetectable
1ru9L-1uf1A:
undetectable		 1ru9H-1uf1A:
21.05
1ru9L-1uf1A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1uf1 KIAA1526 PROTEIN
(Homo
sapiens) 		4 / 6 LEU A  96
ASN A  74
LEU A  89
PHE A  78
 None
 1.41A 1rukH-1uf1A:
undetectable
1rukL-1uf1A:
undetectable		 1rukH-1uf1A:
21.05
1rukL-1uf1A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1uf1 KIAA1526 PROTEIN
(Homo
sapiens) 		3 / 3 HIS A  83
ILE A  81
LEU A  90
 None
 0.76A 2kceA-1uf1A:
undetectable		 2kceA-1uf1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1uf1 KIAA1526 PROTEIN
(Homo
sapiens) 		5 / 8 GLY A  35
LEU A  36
VAL A  73
VAL A  87
LEU A  98
 None
 1.23A 6czmD-1uf1A:
undetectable
6czmF-1uf1A:
undetectable		 6czmD-1uf1A:
18.18
6czmF-1uf1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1uf1 KIAA1526 PROTEIN
(Homo
sapiens) 		5 / 10 VAL A  73
VAL A  87
LEU A  98
GLY A  35
LEU A  36
 None
 1.22A 6czmE-1uf1A:
undetectable
6czmF-1uf1A:
undetectable		 6czmE-1uf1A:
18.18
6czmF-1uf1A:
18.18